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AMR Drug RepurposingSmart Screeningresearch prototype

Dimercaprol

FDA-approved product (injectable, injection), marketed as Bal.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Dimercaprol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Dimercaprol. Its therapeutic class is shown instead.

WHO therapeutic group
Antidotes
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Dimercaprol, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA15.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli13.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis16.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Dimercaprol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Dimercaprol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Observational Study of Raxibacumab in Sporadic Cases of Systemic Anthrax

    NCT07478471 · start 2027-05

    Registered record
    Registry ID
    NCT07478471
    Conditions
    Infections, Bacterial
    Interventions
    Collection of samples
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2027-05
    Completion
    2030-12
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections, Bacterial
    InterventionCollection of samples
    PhaseNot recorded
    Registry statusNot yet recruiting

  • ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia

    NCT07245888 · start 2026-05-01

    Registered record
    Registry ID
    NCT07245888
    Conditions
    Ventilator Acquired Pneumonia; Mechanical Ventilation Complication
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2026-05-01
    Completion
    2027-12
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentilator Acquired Pneumonia; Mechanical Ventilation Complication
    InterventionNot recorded
    PhaseNot recorded
    Registry statusRecruiting

  • Association of Nutrition and T Cell Immune Activity With Disease Progression in Nontuberculous Mycobacterial Pulmonary Disease

    NCT07363798 · start 2026-01

    Registered record
    Registry ID
    NCT07363798
    Conditions
    Nontuberculous Mycobacterial Pulmonary Disease; Nontuberculous Mycobacterial Lung Disease
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2026-01
    Completion
    2027-12-31
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNontuberculous Mycobacterial Pulmonary Disease; Nontuberculous Mycobacterial Lung Disease
    InterventionNot recorded
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Herpes Simplex Virus Type 1 Infection/Reactivation of Patients With Severe Pneumonia（the HSV-SP Study）

    NCT06936683 · start 2025-06-01

    Registered record
    Registry ID
    NCT06936683
    Conditions
    Severe Pneumonia
    Interventions
    Bronchoalveolar Lavage (BAL) via Fiberoptic Bronchoscopy; throat Swab
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2025-06-01
    Completion
    2027-10-01
    Enrolment
    323

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSevere Pneumonia
    InterventionBronchoalveolar Lavage (BAL) via Fiberoptic Bronchoscopy; throat Swab
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Development of a Novel Non-invasive Inflammometry Following Allergen Challenge in Patients With Mild Allergic Asthma

    NCT06317909 · start 2024-08-09

    Registered record
    Registry ID
    NCT06317909
    Conditions
    Mild Allergic Asthma
    Interventions
    allergen challenge
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-08-09
    Completion
    2027-03
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMild Allergic Asthma
    Interventionallergen challenge
    PhaseNot applicable
    Registry statusRecruiting

  • Pattern Of Isolated Fungi From Bronchoalveolar Lavage Among Patients With Bronchial Asthma

    NCT06376617 · start 2024-04-25

    Registered record
    Registry ID
    NCT06376617
    Conditions
    Bronchial Asthma
    Interventions
    fibroptic bronchoscopy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-04-25
    Completion
    2025-05-20
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchial Asthma
    Interventionfibroptic bronchoscopy
    PhaseNot applicable
    Registry statusUnknown

  • The Efficacy and Adverse Reactions of Neotetracycline in the Treatment of GNB Infections

    NCT06990126 · start 2024-03-01

    Registered record
    Registry ID
    NCT06990126
    Conditions
    Clinical Efficacy and Safety
    Interventions
    bronchoscope
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Enrolling by invitation
    Start
    2024-03-01
    Completion
    2026-07-30
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClinical Efficacy and Safety
    Interventionbronchoscope
    PhaseNot recorded
    Registry statusEnrolling by invitation

  • BAL Contribution to Lung Cryo-TBB in ILD

    NCT07130110 · start 2023-12-20

    Registered record
    Registry ID
    NCT07130110
    Conditions
    Bronchoalveolar Lavage (BAL); Transbronchial Cryobiopsy; Interstitial Lung Disease (ILD)
    Interventions
    Transbronchial cryobiopsy; Bronchoalveolar Lavage
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-12-20
    Completion
    2024-09-30
    Enrolment
    127

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchoalveolar Lavage (BAL); Transbronchial Cryobiopsy; Interstitial Lung Disease (ILD)
    InterventionTransbronchial cryobiopsy; Bronchoalveolar Lavage
    PhaseNot applicable
    Registry statusCompleted

  • ALI/ARDS Clinical Sub-phenotyping Study

    NCT06123962 · start 2023-12-14

    Registered record
    Registry ID
    NCT06123962
    Conditions
    Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
    Interventions
    Collect peripheral blood and bronchoalveolar lavage fluid
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2023-12-14
    Completion
    2025-12-31
    Enrolment
    1,500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
    InterventionCollect peripheral blood and bronchoalveolar lavage fluid
    PhaseNot recorded
    Registry statusRecruiting

  • Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia

    NCT06475976 · start 2023-12-05

    Registered record
    Registry ID
    NCT06475976
    Conditions
    Bronchopulmonary Dysplasia
    Interventions
    Chest computed tomography (CT) with angiography; Bronchoscopy with bronchoalveolar lavage; Echocardiography; 24 hour esophageal pH ("potential of hydrogen") - multichannel intraluminal impedance (MII) monitoring (reflux testing)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2023-12-05
    Completion
    2029-07-31
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchopulmonary Dysplasia
    InterventionChest computed tomography (CT) with angiography; Bronchoscopy with bronchoalveolar lavage; Echocardiography; 24 hour esophageal pH ("potential of hydrogen") - multichannel intraluminal impedance (MII) monitoring (reflux testing)
    PhaseNot recorded
    Registry statusRecruiting

  • Metagenomic NGS for Diagnosis of Pneumonia

    NCT05979350 · start 2023-08-07

    Registered record
    Registry ID
    NCT05979350
    Conditions
    Pneumonia; Diagnosis
    Interventions
    Metagenomic next-generation sequencing; Standard work-up for pneumonia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2023-08-07
    Completion
    2025-11-30
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Diagnosis
    InterventionMetagenomic next-generation sequencing; Standard work-up for pneumonia
    PhaseNot applicable
    Registry statusActive not recruiting

  • Flexible Bronchoscopy in Resistant Pneumonia in PICU

    NCT07421440 · start 2023-02-05

    Registered record
    Registry ID
    NCT07421440
    Conditions
    Pneumonia; Resistant Pneumonia; Resistant Pneumonia in Critically Ill Pedaitric Patients
    Interventions
    Flexible fiberoptic bronchoscopy with bronchoalveolar lavage (BAL)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2023-02-05
    Completion
    2025-08-03
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Resistant Pneumonia; Resistant Pneumonia in Critically Ill Pedaitric Patients
    InterventionFlexible fiberoptic bronchoscopy with bronchoalveolar lavage (BAL)
    PhaseNot recorded
    Registry statusCompleted

  • Molecular vs Conventional Microbiologic Diagnosis for Infections in Lung Transplantation

    NCT05960383 · start 2023-02-02

    Registered record
    Registry ID
    NCT05960383
    Conditions
    Lung Transplant Infection; Molecular Diagnostic; Bacterial Infections; Pneumonia; Tracheobronchitis
    Interventions
    BioFire Pneumonia Panel Plus
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2023-02-02
    Completion
    2024-11-01
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLung Transplant Infection; Molecular Diagnostic; Bacterial Infections; Pneumonia +1 more
    InterventionBioFire Pneumonia Panel Plus
    PhaseNot recorded
    Registry statusUnknown

  • Prospective Study on the Efficacy and Safety of Bronchoalveolar Lavage Combined With Pathogen Metagenomic Sequencing Technology in the Diagnosis of Immune Checkpoint Inhibitor Associated Pneumonia

    NCT06192303 · start 2023-01-01

    Registered record
    Registry ID
    NCT06192303
    Conditions
    Immune Checkpoint Inhibitor Associated Pneumonia
    Interventions
    Bronchoalveolar lavage and pathogen metagenomic sequencing
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2023-01-01
    Completion
    2026-01-01
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImmune Checkpoint Inhibitor Associated Pneumonia
    InterventionBronchoalveolar lavage and pathogen metagenomic sequencing
    PhaseNot recorded
    Registry statusUnknown

  • Remodelling of the Lower Airways in Chronic Cough

    NCT07659860 · start 2022-10-01

    Registered record
    Registry ID
    NCT07659860
    Conditions
    Chronic Cough
    Interventions
    chest computed tomography and bronchoscopy
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2022-10-01
    Completion
    2026-08-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Cough
    Interventionchest computed tomography and bronchoscopy
    PhaseNot recorded
    Registry statusRecruiting