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AMR Drug RepurposingSmart Screeningresearch prototype

Dimercaprol

FDA-approved product (injectable, injection), marketed as Bal.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Dimercaprol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Dimercaprol. Its therapeutic class is shown instead.

WHO therapeutic group
Antidotes
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Dimercaprol, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA15.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli13.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis16.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Dimercaprol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Dimercaprol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Perpetual Observational Study - Ventilator Associated Pneumonia

    NCT05719259 · start 2022-08-03

    Registered record
    Registry ID
    NCT05719259
    Conditions
    Ventilator Associated Pneumonia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2022-08-03
    Completion
    2027-03-01
    Enrolment
    20,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentilator Associated Pneumonia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusRecruiting

  • M-ROSE Combined With mNGS in Severe Hospital-acquired Pneumonia

    NCT05300776 · start 2022-05

    Registered record
    Registry ID
    NCT05300776
    Conditions
    Pneumonia
    Interventions
    M-ROSE analysis
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-05
    Completion
    2024-12-31
    Enrolment
    166

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionM-ROSE analysis
    PhaseNot applicable
    Registry statusUnknown

  • The Diagnosis of Superinfections in Mechanically Ventilated Covid-19 Patients

    NCT05148975 · start 2021-12-11

    Registered record
    Registry ID
    NCT05148975
    Conditions
    COVID-19 Pneumonia; Superinfection; ARDS, Human
    Interventions
    Bronchoalveolar lavage fluid diagnostics
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2021-12-11
    Completion
    2023-03-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID-19 Pneumonia; Superinfection; ARDS, Human
    InterventionBronchoalveolar lavage fluid diagnostics
    PhaseNot recorded
    Registry statusUnknown

  • Randomized Trial of COVID-19 Booster Vaccinations (Cobovax Study)

    NCT05057169 · start 2021-11-18

    Registered record
    Registry ID
    NCT05057169
    Conditions
    COVID-19 Vaccination
    Interventions
    BNT162b2; CoronaVac
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-11-18
    Completion
    2025-12-31
    Enrolment
    451

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID-19 Vaccination
    InterventionBNT162b2; CoronaVac
    PhasePhase 4
    Registry statusCompleted

  • Thymic Function in Patients With COVID-19

    NCT04716907 · start 2021-03-19

    Registered record
    Registry ID
    NCT04716907
    Conditions
    Covid19
    Interventions
    Single-Nucleotide Polymorphisms (SNP) within the TCRA/D region; Blood sample; CT Scan; Bronchial fibroscopy
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-03-19
    Completion
    2022-04-02
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCovid19
    InterventionSingle-Nucleotide Polymorphisms (SNP) within the TCRA/D region; Blood sample; CT Scan; Bronchial fibroscopy
    PhaseNot recorded
    Registry statusCompleted

  • Bronchoalveolar Lavage in Recovered From COVID-19 Pneumonia

    NCT06022198 · start 2021-01-01

    Registered record
    Registry ID
    NCT06022198
    Conditions
    Bronchoalveolar Lavage
    Interventions
    Bronchoalveolar Lavage
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-01-01
    Completion
    2023-01-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchoalveolar Lavage
    InterventionBronchoalveolar Lavage
    PhaseNot applicable
    Registry statusCompleted

  • Rapid Diagnostic Supporting Antimicrobial Stewardship in Patients With Pneumonia

    NCT05937126 · start 2020-09-15

    Registered record
    Registry ID
    NCT05937126
    Conditions
    Lower Respiratory Tract Infections
    Interventions
    FilmArray Pneumonia Panel; Culture and antimicrobial susceptibility testing
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-09-15
    Completion
    2022-09-19
    Enrolment
    1,203

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLower Respiratory Tract Infections
    InterventionFilmArray Pneumonia Panel; Culture and antimicrobial susceptibility testing
    PhaseNot recorded
    Registry statusCompleted

  • Fiberoptic Bronchoscopy and Bronchoalveolar Lavage in Critically Ill Ventilated Patients

    NCT04502368 · start 2020-09-01

    Registered record
    Registry ID
    NCT04502368
    Conditions
    Fiberoptic Bronchoscopy (FOB); Bronchoalveolar Lavage (BAL); Respiratory Disease
    Interventions
    Fiberoptic Bronchoscopy (FOB); Bronchoalveolar Lavage (BAL); Electrical Impedance Tomography (EIT); Arterial Blood Gas test (ABG)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2020-09-01
    Completion
    2021-04-30
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFiberoptic Bronchoscopy (FOB); Bronchoalveolar Lavage (BAL); Respiratory Disease
    InterventionFiberoptic Bronchoscopy (FOB); Bronchoalveolar Lavage (BAL); Electrical Impedance Tomography (EIT); Arterial Blood Gas test (ABG)
    PhaseNot recorded
    Registry statusUnknown

  • Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches

    NCT04410263 · start 2020-04-09

    Registered record
    Registry ID
    NCT04410263
    Conditions
    Corona Virus Infection; ARDS; Coinfection
    Interventions
    Sampling (EDTA blood, pharyngeal and nose swabs, bronchoalveolar lavage ,urine)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2020-04-09
    Completion
    2023-12-31
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCorona Virus Infection; ARDS; Coinfection
    InterventionSampling (EDTA blood, pharyngeal and nose swabs, bronchoalveolar lavage ,urine)
    PhaseNot recorded
    Registry statusUnknown

  • Standardized BAL Procedure for Critical Patients to Diagnose Pneumonia Pathogens

    NCT04200742 · start 2019-09-16

    Registered record
    Registry ID
    NCT04200742
    Conditions
    Bronchoalveolar Lavage; Pneumonia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2019-09-16
    Completion
    2020-06-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchoalveolar Lavage; Pneumonia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Imaging Activated Macrophages in the Lungs

    NCT03494114 · start 2018-11-29

    Registered record
    Registry ID
    NCT03494114
    Conditions
    COPD
    Interventions
    Ga-EC2115
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2018-11-29
    Completion
    2021-01-13
    Enrolment
    13

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOPD
    InterventionGa-EC2115
    PhasePhase 1
    Registry statusTerminated

  • Pattern of Isolated Fungi From Bronchoalveolar Lavage Among Patients With Lung Cancer

    NCT05575388 · start 2018-03-01

    Registered record
    Registry ID
    NCT05575388
    Conditions
    Lung Cancer
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-03-01
    Completion
    2020-10-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLung Cancer
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Airway Clearance and Bronchoalveolar Lavage for Bronchiectasis Patients With Exacerbation

    NCT03643302 · start 2018-02-01

    Registered record
    Registry ID
    NCT03643302
    Conditions
    Bronchiectasis Adult
    Interventions
    Version BF-1T26 electronic bronchoscope
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-02-01
    Completion
    2019-03-18
    Enrolment
    189

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchiectasis Adult
    InterventionVersion BF-1T26 electronic bronchoscope
    PhaseNot recorded
    Registry statusCompleted

  • Preliminary Study on the Clinical Application Value of "Showering Cells" in Diagnosing Aspiration Pneumonia

    NCT07707206 · start 2018-01-12

    Registered record
    Registry ID
    NCT07707206
    Conditions
    Pneumonia, Aspiration
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-01-12
    Completion
    2026-03-21
    Enrolment
    430

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Aspiration
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Second-generation Sequencing Guides the Treatment of Severe Pneumonia

    NCT03884881 · start 2018-01-01

    Registered record
    Registry ID
    NCT03884881
    Conditions
    Pneumonia; Metagenomic Next Generation Sequencing
    Interventions
    metagenomic next generation sequencing; Conventional pathogen detection; Meropenem，Imipenem，Caspofene，Osstat
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-01-01
    Completion
    2019-12-01
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia; Metagenomic Next Generation Sequencing
    Interventionmetagenomic next generation sequencing; Conventional pathogen detection; Meropenem，Imipenem，Caspofene，Osstat
    PhaseNot applicable
    Registry statusUnknown