Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Dimercaprol

FDA-approved product (injectable, injection), marketed as Bal.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Dimercaprol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Dimercaprol. Its therapeutic class is shown instead.

WHO therapeutic group
Antidotes
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Dimercaprol, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA15.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli13.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis16.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Dimercaprol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Dimercaprol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Doses of Inhaled GSK1995057

    NCT01587807 · start 2012-03-28

    Registered record
    Registry ID
    NCT01587807
    Conditions
    Respiratory Disorders
    Interventions
    GSK1995057; bronchoalveolar lavage; LPS; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-03-28
    Completion
    2012-11-19
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Disorders
    InterventionGSK1995057; bronchoalveolar lavage; LPS; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Induced Sputum Versus Bronchoscopy in Smear Negative Pulmonary Tuberculosis

    NCT01011543 · start 2009-08

    Registered record
    Registry ID
    NCT01011543
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Diagnostic techniques in pulmonary tuberculosis
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-08
    Completion
    2015-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionDiagnostic techniques in pulmonary tuberculosis
    PhaseNot applicable
    Registry statusCompleted

  • Transbronchial Needle Aspiration in the Diagnosis of Peripheral Pulmonary Malignancy

    NCT00917137 · start 2008-07

    Registered record
    Registry ID
    NCT00917137
    Conditions
    Pulmonary Nodule; Pulmonary Mass
    Interventions
    TBNA + transbronchial lung biopsy + bronchial washing
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-07
    Completion
    2010-06
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Nodule; Pulmonary Mass
    InterventionTBNA + transbronchial lung biopsy + bronchial washing
    PhaseNot recorded
    Registry statusCompleted

  • Diagnosing Pulmonary Aspergillosis in Patients With Hematological Malignancies: A Multicentre Prospective Evaluation of an Aspergillus PCR Assay and a Galactomannan ELISA in Bronchoalveolar Lavage Samples

    NCT01430663 · start 2007-04

    Registered record
    Registry ID
    NCT01430663
    Conditions
    Invasive Aspergillosis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-04
    Completion
    2011-02
    Enrolment
    87

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Aspergillosis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis

    NCT00001541 · start 1996-04

    Registered record
    Registry ID
    NCT00001541
    Conditions
    Inflammation; Vasculitis; Wegener's Granulomatosis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    1996-04
    Completion
    2003-01
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammation; Vasculitis; Wegener's Granulomatosis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted