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AMR Drug RepurposingSmart Screeningresearch prototype

Citalopram Hydrobromide

FDA-approved product (tablet, oral), marketed as Celexa, Citalopram Hydrobromide.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Citalopram Hydrobromide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Depressive disorder
  • Major depressive disorder

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Selective serotonin reuptake inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA41.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli33.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae20.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Citalopram Hydrobromide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-9.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Citalopram Hydrobromide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

    NCT03511118 · start 2018-10-04

    Registered record
    Registry ID
    NCT03511118
    Conditions
    Lactating Women on Select DOI; Breastfed Infants of Mothers on Select DOI
    Interventions
    Tranexamic acid (TXA); labetalol; metformin; nifedipine; clindamycin; oxycodone; azithromycin; escitalopram; sertraline; ondansetron; Ciprofloxacin; Doxycycline; Levofloxacin; Methylphenidate; Sumatriptan; Citalopram; Cyclobenzaprine; Furosemide; Gabapentin; Hydrochlorothiazide; Hydroxyurea; Rosuvastatin; Topiramate; Trazodone; Valganciclovir; Venlafaxine; Verapamil; Remdesivir; Anakinra; Tocilizumab; Fluvoxamine; Amoxicillin; Bupropion; Duloxetine; Hydrocodone; Levetiracetam; Paroxetine; Buprenorphine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2018-10-04
    Completion
    2028-07-31
    Enrolment
    1,600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLactating Women on Select DOI; Breastfed Infants of Mothers on Select DOI
    InterventionTranexamic acid (TXA); labetalol; metformin; nifedipine +34 more
    PhaseNot recorded
    Registry statusRecruiting

  • Bariatric Surgery and Pharmacokinetics of Escitalopram

    NCT03460379 · start 2016-11-02

    Registered record
    Registry ID
    NCT03460379
    Conditions
    Obesity, Morbid
    Interventions
    Escitalopram
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2016-11-02
    Completion
    2026-10
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity, Morbid
    InterventionEscitalopram
    PhaseNot recorded
    Registry statusRecruiting

  • eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients

    NCT02458690 · start 2015-07

    Registered record
    Registry ID
    NCT02458690
    Conditions
    Depression; Major Depressive Disorder; Dysthymic Disorder; Depressive Symptoms; Cardiovascular Diseases; Heart Diseases; Coronary Artery Disease; Stroke
    Interventions
    Beating the Blues (BtB); Problem Solving Treatment in Primary Care (PST-PC); Antidepressant Medications; Usual Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-07
    Completion
    2021-03
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression; Major Depressive Disorder; Dysthymic Disorder; Depressive Symptoms +4 more
    InterventionBeating the Blues (BtB); Problem Solving Treatment in Primary Care (PST-PC); Antidepressant Medications; Usual Care
    PhasePhase 2
    Registry statusCompleted

  • Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients

    NCT02022709 · start 2014-01

    Registered record
    Registry ID
    NCT02022709
    Conditions
    Obsessive-Compulsive Disorder; Anxiety Disorders; Mental Disorders
    Interventions
    Fluoxetine; Sertraline; Paroxetine; Citalopram; Fluvoxamine; Exposure and Response Prevention
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-01
    Completion
    2018-03-13
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive-Compulsive Disorder; Anxiety Disorders; Mental Disorders
    InterventionFluoxetine; Sertraline; Paroxetine; Citalopram +2 more
    PhasePhase 4
    Registry statusCompleted

  • Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder

    NCT01838876 · start 2013-04-29

    Registered record
    Registry ID
    NCT01838876
    Conditions
    Major Depressive Disorder
    Interventions
    Cariprazine; Antidepressant Therapy (ADT)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-04-29
    Completion
    2015-07-27
    Enrolment
    442

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionCariprazine; Antidepressant Therapy (ADT)
    PhasePhase 3
    Registry statusCompleted

  • Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD)

    NCT01715805 · start 2012-11-15

    Registered record
    Registry ID
    NCT01715805
    Conditions
    Major Depressive Disorder
    Interventions
    Cariprazine; Placebo; Antidepressant Therapy (ADT)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-11-15
    Completion
    2016-06-24
    Enrolment
    1,022

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionCariprazine; Placebo; Antidepressant Therapy (ADT)
    PhasePhase 3
    Registry statusCompleted

  • An Objective Double-blind Evaluation of Bupropion and Citalopram in an Individual With Friedreich Ataxia

    NCT01716221 · start 2012-10

    Registered record
    Registry ID
    NCT01716221
    Conditions
    Friedreich Ataxia
    Interventions
    bupropion & Citalopram; Bupropion & Placebo; Placebo & Citalopram; Placebo & Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-10
    Completion
    2013-03
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFriedreich Ataxia
    Interventionbupropion & Citalopram; Bupropion & Placebo; Placebo & Citalopram; Placebo & Placebo
    PhasePhase 4
    Registry statusCompleted

  • Antidepressants and Bone Mineral Density

    NCT02179268 · start 2012-03

    Registered record
    Registry ID
    NCT02179268
    Conditions
    Bone Mineral Density Quantitative Trait Locus 7
    Interventions
    sertraline; citalopram; venlafaxine; reboxetine; control
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-03
    Completion
    2014-04
    Enrolment
    203

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBone Mineral Density Quantitative Trait Locus 7
    Interventionsertraline; citalopram; venlafaxine; reboxetine +1 more
    PhasePhase 3
    Registry statusCompleted

  • Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers

    NCT04355455 · start 2011-07

    Registered record
    Registry ID
    NCT04355455
    Conditions
    Gastroesophageal Reflux
    Interventions
    Citalopram; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-07
    Completion
    2012-01
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastroesophageal Reflux
    InterventionCitalopram; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Quetiapine XR in Depressive Patients Showing Aberrant N100 Amplitude Slope

    NCT01357967 · start 2011-05

    Registered record
    Registry ID
    NCT01357967
    Conditions
    Major Depressive Disorder
    Interventions
    SSRI monotherapy; Seroquel XR adjunctive
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-05
    Completion
    2013-04
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionSSRI monotherapy; Seroquel XR adjunctive
    PhasePhase 4
    Registry statusUnknown

  • Adjunctive Mixed Salts Amphetamine for Depressed Adults With Incomplete Response to Current Antidepressant Therapy

    NCT02058693 · start 2010-12

    Registered record
    Registry ID
    NCT02058693
    Conditions
    Major Depressive Disorder
    Interventions
    mixed salts amphetamine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-12
    Completion
    2014-12
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    Interventionmixed salts amphetamine
    PhasePhase 4
    Registry statusCompleted

  • Study of Repetitive Transcranial Magnetic Stimulation (rTMS) as Adjuvant Treatment for Depression

    NCT01115699 · start 2010-04

    Registered record
    Registry ID
    NCT01115699
    Conditions
    Depression
    Interventions
    Repetitive Transcranial Magnetic Stimulation (rTMS)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-04
    Completion
    2012-03
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    InterventionRepetitive Transcranial Magnetic Stimulation (rTMS)
    PhaseNot applicable
    Registry statusTerminated

  • Brain Function and Structure in Cocaine Dependence

    NCT02080832 · start 2010-02

    Registered record
    Registry ID
    NCT02080832
    Conditions
    Cocaine Dependence
    Interventions
    Citalopram; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-02
    Completion
    2016-02
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine Dependence
    InterventionCitalopram; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Comparison of Depression Interventions After Acute Coronary Syndrome

    NCT01032018 · start 2010-01

    Registered record
    Registry ID
    NCT01032018
    Conditions
    Acute Coronary Syndrome; Depression
    Interventions
    Problem Solving Therapy; Sertraline, citalopram, or bupropion; Standard care
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2010-01
    Completion
    2012-07
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome; Depression
    InterventionProblem Solving Therapy; Sertraline, citalopram, or bupropion; Standard care
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • DECIFER: Depression and Citalopram In First Episode Recovery

    NCT01041274 · start 2010-01

    Registered record
    Registry ID
    NCT01041274
    Conditions
    Schizophrenia; Schizophreniform Disorder
    Interventions
    Citalopram; Placebo; Psychoeducation; Cognitive Behavioral Therapy (CBT); Functional Magnetic Resonance Imaging (fMRI)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-01
    Completion
    2018-03-26
    Enrolment
    95

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizophreniform Disorder
    InterventionCitalopram; Placebo; Psychoeducation; Cognitive Behavioral Therapy (CBT) +1 more
    PhasePhase 4
    Registry statusCompleted