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AMR Drug RepurposingSmart Screeningresearch prototype

Citalopram Hydrobromide

FDA-approved product (tablet, oral), marketed as Celexa, Citalopram Hydrobromide.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Citalopram Hydrobromide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Depressive disorder
  • Major depressive disorder

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Selective serotonin reuptake inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA41.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli33.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae20.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Citalopram Hydrobromide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-9.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Citalopram Hydrobromide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Citalopram for Agitation in Alzheimer's Disease

    NCT00898807 · start 2009-07

    Registered record
    Registry ID
    NCT00898807
    Conditions
    Alzheimer's Disease; Agitation
    Interventions
    citalopram; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-07
    Completion
    2013-09
    Enrolment
    186

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease; Agitation
    Interventioncitalopram; placebo
    PhasePhase 3
    Registry statusCompleted

  • Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression

    NCT00944996 · start 2009-06

    Registered record
    Registry ID
    NCT00944996
    Conditions
    Major Depression
    Interventions
    SSRI; SNRI; TCA
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-06
    Completion
    2012-07
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depression
    InterventionSSRI; SNRI; TCA
    PhaseNot applicable
    Registry statusCompleted

  • N-methylglycine (Sarcosine) Treatment for Depression

    NCT00977353 · start 2009-04

    Registered record
    Registry ID
    NCT00977353
    Conditions
    Major Depressive Disorder; Depression; Major Depression
    Interventions
    citalopram; sarcosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-04
    Completion
    2011-07
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Depression; Major Depression
    Interventioncitalopram; sarcosine
    PhasePhase 2
    Registry statusCompleted

  • Effects of Intravenous (IV) Citalopram on Emotional Brain Activity in Healthy Young and Elderly Adults

    NCT01216449 · start 2009-04

    Registered record
    Registry ID
    NCT01216449
    Conditions
    Healthy Young and Elderly Volunteers
    Interventions
    Intravenous Citalopram; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2009-04
    Completion
    2016-03
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Young and Elderly Volunteers
    InterventionIntravenous Citalopram; Normal Saline
    PhaseNot applicable
    Registry statusTerminated

  • Emotional Processing in Healthy Volunteers in the Presence of an Investigational Anxiolytic

    NCT01424384 · start 2008-09-19

    Registered record
    Registry ID
    NCT01424384
    Conditions
    Depressive Disorder and Anxiety Disorders
    Interventions
    Citalopram; GSK424887; Plactebo To Match
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-09-19
    Completion
    2009-04-30
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepressive Disorder and Anxiety Disorders
    InterventionCitalopram; GSK424887; Plactebo To Match
    PhasePhase 1
    Registry statusCompleted

  • Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms

    NCT00955474 · start 2008-09

    Registered record
    Registry ID
    NCT00955474
    Conditions
    Major Depressive Disorder With Psychotic Features
    Interventions
    Quetiapine; escitalopram; Sertraline; Citalopram
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2008-09
    Completion
    2013-01
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder With Psychotic Features
    InterventionQuetiapine; escitalopram; Sertraline; Citalopram
    PhasePhase 4
    Registry statusTerminated

  • Dementia Antipsychotics And Antidepressants Discontinuation Study

    NCT00594269 · start 2008-08

    Registered record
    Registry ID
    NCT00594269
    Conditions
    Dementia
    Interventions
    Risperidone; Escitalopram; Citalopram; Sertraline; Paroxetine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-08
    Completion
    2010-12
    Enrolment
    149

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDementia
    InterventionRisperidone; Escitalopram; Citalopram; Sertraline +1 more
    PhasePhase 4
    Registry statusCompleted

  • Comparison of the Pharmacokinetics of Two Generic Antidepressants and Their Respective Brand Preparations

    NCT00676039 · start 2007-11

    Registered record
    Registry ID
    NCT00676039
    Conditions
    Healthy
    Interventions
    Venlafaxine; Gen-Citalopram; Effexor XR; Celexa
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-11
    Completion
    2008-07
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionVenlafaxine; Gen-Citalopram; Effexor XR; Celexa
    PhasePhase 1
    Registry statusCompleted

  • Trial of Citalopram for the Prevention of Depression

    NCT00317746 · start 2006-11

    Registered record
    Registry ID
    NCT00317746
    Conditions
    Depression; HIV Infections; Hepatitis C
    Interventions
    Citalopram; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-11
    Completion
    2012-03
    Enrolment
    76

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression; HIV Infections; Hepatitis C
    InterventionCitalopram; Placebos
    PhasePhase 3
    Registry statusCompleted

  • Citalopram in Treating Postmenopausal Women With Hot Flashes

    NCT00363909 · start 2006-11

    Registered record
    Registry ID
    NCT00363909
    Conditions
    Breast Cancer; Hot Flashes; Psychosocial Effects of Cancer and Its Treatment
    Interventions
    citalopram hydrobromide; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-11
    Completion
    2010-12
    Enrolment
    254

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer; Hot Flashes; Psychosocial Effects of Cancer and Its Treatment
    Interventioncitalopram hydrobromide; placebo
    PhasePhase 3
    Registry statusCompleted

  • Treatment of Mood and Marriage Study (TOMMS)

    NCT00612807 · start 2006-07

    Registered record
    Registry ID
    NCT00612807
    Conditions
    Major Depressive Disorder; Partner Relational Disorder (V61.10)
    Interventions
    Weekly marital therapy; As indicated: Sertraline, bupropion, venlafaxine, mirtazepine, nortriptyline, tranylcypromine, lithium augmentation, etc.
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2006-07
    Completion
    2010-06
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Partner Relational Disorder (V61.10)
    InterventionWeekly marital therapy; As indicated: Sertraline, bupropion, venlafaxine, mirtazepine, nortriptyline, tranylcypromine, lithium augmentation, etc.
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Group Cognitive Behavioral Therapy Versus Fluoxetine for Obsessive-Compulsive Disorder: a Practical Trial

    NCT00680602 · start 2006-01

    Registered record
    Registry ID
    NCT00680602
    Conditions
    Obsessive Compulsive Disorder
    Interventions
    Group Cognitive Behavior Therapy; SSRI (fluoxetine, sertraline, paroxetine, citalopram)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-01
    Completion
    2008-09
    Enrolment
    158

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder
    InterventionGroup Cognitive Behavior Therapy; SSRI (fluoxetine, sertraline, paroxetine, citalopram)
    PhasePhase 4
    Registry statusCompleted

  • Cognitive Flexibility in Major Depression in the Course of Pharmacological and Psychotherapeutic Treatment

    NCT00993876 · start 2005-08

    Registered record
    Registry ID
    NCT00993876
    Conditions
    Cognitive Performance in Major Depression
    Interventions
    citalopram; reboxetine; interpersonal psychotherapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-08
    Completion
    2008-08
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCognitive Performance in Major Depression
    Interventioncitalopram; reboxetine; interpersonal psychotherapy
    PhaseNot applicable
    Registry statusCompleted

  • Use of Functional Behavioral Assessments to Evaluate Stereotypy and Repetitive Behaviors in a Double-blind, Placebo Controlled Trials of Various Medications Used to Treat Children With Autism.

    NCT00211770 · start 2005-02

    Registered record
    Registry ID
    NCT00211770
    Conditions
    Autism
    Interventions
    Behavioral Assessment
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2005-02
    Completion
    2012-12
    Enrolment
    144

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutism
    InterventionBehavioral Assessment
    PhaseNot recorded
    Registry statusCompleted

  • Effect of the Menstrual Cycle on the Symptoms of Depression and Treatment Response

    NCT00188396 · start 2004-04

    Registered record
    Registry ID
    NCT00188396
    Conditions
    Major Depressive Disorder; Depression
    Interventions
    Citalopram
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-04
    Completion
    2008-10
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Depression
    InterventionCitalopram
    PhaseNot applicable
    Registry statusCompleted