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AMR Drug RepurposingSmart Screeningresearch prototype

Triclosan

FDA-approved product (paste, dental).

Registered studies
50+
Lab records
8
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Triclosan
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Triclosan. Its therapeutic class is shown instead.

WHO therapeutic group
Phenol and derivatives; Medicated dressings with antiinfectives
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC D08AE04; WHO ATC D09AA06

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA64.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli81.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae68.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis84.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 2 of 2 lab records
  • K. pneumoniae: measured active in 1 of 2 lab records
  • M. tuberculosis: measured active in 2 of 2 lab records
Open Triclosan in ChEMBL Registered studies below
Show the 8 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triclosan with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Evaluate Inflammation Caused by Gingivitis in Adults

    NCT00941668 · start 2007-01

    Registered record
    Registry ID
    NCT00941668
    Conditions
    Gingivitis
    Interventions
    Triclosan/Copolymer/fluoride toothpaste; sodium monofluorophosphate toothpaste
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-01
    Completion
    2008-08
    Enrolment
    49

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingivitis
    InterventionTriclosan/Copolymer/fluoride toothpaste; sodium monofluorophosphate toothpaste
    PhasePhase 4
    Registry statusCompleted

  • A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections

    NCT01049438 · start 2006-08

    Registered record
    Registry ID
    NCT01049438
    Conditions
    Methicillin Resistant Staphylococcus Aureus Skin Infections
    Interventions
    nasal mupirocin; topical 3% hexachlorophene body wash; oral anti-MRSA antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-08
    Completion
    2009-09
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus Skin Infections
    Interventionnasal mupirocin; topical 3% hexachlorophene body wash; oral anti-MRSA antibiotic
    PhaseNot applicable
    Registry statusCompleted

  • Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic Population

    NCT00762762 · start 2006-03

    Registered record
    Registry ID
    NCT00762762
    Conditions
    Periodontitis
    Interventions
    Triclosan/copolymer/fluoride; Fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-03
    Completion
    2008-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis
    InterventionTriclosan/copolymer/fluoride; Fluoride
    PhasePhase 3
    Registry statusCompleted

  • Antiseptic Sutures and Wound Infection

    NCT00932503 · start 2003-10

    Registered record
    Registry ID
    NCT00932503
    Conditions
    Wound Infection
    Interventions
    Vicryl plus
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-10
    Completion
    2007-10
    Enrolment
    839

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Infection
    InterventionVicryl plus
    PhaseNot applicable
    Registry statusCompleted

  • Periodontal Disease and Cardiovascular Disease

    NCT00763165 · start 2000-11

    Registered record
    Registry ID
    NCT00763165
    Conditions
    Periodontal Diseases
    Interventions
    Triclosan; Fluoride; Fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2000-11
    Completion
    2009-12
    Enrolment
    438

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Diseases
    InterventionTriclosan; Fluoride; Fluoride
    PhasePhase 3
    Registry statusUnknown