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AMR Drug RepurposingSmart Screeningresearch prototype

Triclosan

FDA-approved product (paste, dental).

Registered studies
50+
Lab records
8
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Triclosan
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Triclosan. Its therapeutic class is shown instead.

WHO therapeutic group
Phenol and derivatives; Medicated dressings with antiinfectives
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC D08AE04; WHO ATC D09AA06

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA64.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli81.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae68.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis84.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 2 of 2 lab records
  • K. pneumoniae: measured active in 1 of 2 lab records
  • M. tuberculosis: measured active in 2 of 2 lab records
Open Triclosan in ChEMBL Registered studies below
Show the 8 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triclosan with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)

    NCT02366689 · start 2014-06

    Registered record
    Registry ID
    NCT02366689
    Conditions
    Dental Plaque; Gingivitis
    Interventions
    Triclosan/fluoride toothpaste; stannous fluoride toothpaste; fluoride only toothpaste; Cetylpyridinium chloride mouthwash; Fluoride only mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-06
    Completion
    2014-12
    Enrolment
    179

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque; Gingivitis
    InterventionTriclosan/fluoride toothpaste; stannous fluoride toothpaste; fluoride only toothpaste; Cetylpyridinium chloride mouthwash +1 more
    PhasePhase 4
    Registry statusCompleted

  • Clinical Investigation to Examine Toothpaste Effect on Oral Bacteria

    NCT02194621 · start 2014-01

    Registered record
    Registry ID
    NCT02194621
    Conditions
    Oral Bacteria Levels in the Mouth
    Interventions
    Total Flavor option 1; Total Flavor option 2; Placebo toothpaste: Crest Cavity Protection toothpaste
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-01
    Completion
    2014-03
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Bacteria Levels in the Mouth
    InterventionTotal Flavor option 1; Total Flavor option 2; Placebo toothpaste: Crest Cavity Protection toothpaste
    PhasePhase 4
    Registry statusCompleted

  • Study of the Anti-Inflammatory Effects of Colgate Total® During an Experimental Gingivitis Model

    NCT01799226 · start 2013-03

    Registered record
    Registry ID
    NCT01799226
    Conditions
    Gingivitis
    Interventions
    Toothpaste without triclosan; Triclosan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-03
    Completion
    2013-12
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingivitis
    InterventionToothpaste without triclosan; Triclosan
    PhaseNot applicable
    Registry statusCompleted

  • Stanford's Outcomes Research in Kids

    NCT01442701 · start 2011-11-17

    Registered record
    Registry ID
    NCT01442701
    Conditions
    Bacterial, Viral and Other Infectious Agents
    Interventions
    Removal of triclosan-containing cleaning products from household.
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-11-17
    Completion
    2019-12-01
    Enrolment
    361

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial, Viral and Other Infectious Agents
    InterventionRemoval of triclosan-containing cleaning products from household.
    PhaseNot recorded
    Registry statusCompleted

  • Effectiveness of Triclosan Coated Sutures in Preventing Leg Wound Infection After Coronary Artery Bypass Surgery

    NCT01457859 · start 2011-10

    Registered record
    Registry ID
    NCT01457859
    Conditions
    Complication of Coronary Artery Bypass Graft; Surgical Wound Infection
    Interventions
    Triclosan; Conventional non-coated surgical sutures
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-10
    Completion
    2013-10
    Enrolment
    410

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplication of Coronary Artery Bypass Graft; Surgical Wound Infection
    InterventionTriclosan; Conventional non-coated surgical sutures
    PhasePhase 4
    Registry statusUnknown

  • Compare Antimicrobial to Conventional Suture in Patients Receiving Primary Total Knee Replacement

    NCT02533492 · start 2011-06

    Registered record
    Registry ID
    NCT02533492
    Conditions
    Wound Infection
    Interventions
    vicryl; Vicryl plus
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-06
    Completion
    2012-12
    Enrolment
    102

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Infection
    Interventionvicryl; Vicryl plus
    PhasePhase 4
    Registry statusCompleted

  • Clinical Efficacy of the Drug Ster® Compared With Predfort® in Control of Postoperative Inflammation in Cataract Surgery

    NCT01227876 · start 2011-01

    Registered record
    Registry ID
    NCT01227876
    Conditions
    Inflammation; Cataract Surgery
    Interventions
    Ster; Pred Fort
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-01
    Completion
    2011-08
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammation; Cataract Surgery
    InterventionSter; Pred Fort
    PhasePhase 3
    Registry statusCompleted

  • Triclosan Coated Suture Wound Closure for Peripheral Vascular Surgery: a Prospective Multicenter Study

    NCT01101789 · start 2010-04

    Registered record
    Registry ID
    NCT01101789
    Conditions
    Surgical Wound Infection
    Interventions
    triclosan coated suture for surgical wound closure; regular sutures for surgical wound closure
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-04
    Completion
    2011-01
    Enrolment
    276

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Wound Infection
    Interventiontriclosan coated suture for surgical wound closure; regular sutures for surgical wound closure
    PhaseNot applicable
    Registry statusCompleted

  • The Impact of Using Triclosan-antibacterial Sutures on the Incidence of Surgical Site Infection

    NCT01019447 · start 2009-11

    Registered record
    Registry ID
    NCT01019447
    Conditions
    Surgical Site Infection
    Interventions
    Vicryl Plus; Vicryl
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-11
    Completion
    2011-03
    Enrolment
    701

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionVicryl Plus; Vicryl
    PhasePhase 4
    Registry statusCompleted

  • Abdominal Wall Closure With Triclosan-coated Suture (TCS09-10)

    NCT01123616 · start 2009-11

    Registered record
    Registry ID
    NCT01123616
    Conditions
    Wound Infection
    Interventions
    abdominal wall closure
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2009-11
    Completion
    2010-06
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Infection
    Interventionabdominal wall closure
    PhasePhase 2
    Registry statusUnknown

  • PDS*Plus and Wound Infections After Laparotomy

    NCT00998907 · start 2009-09

    Registered record
    Registry ID
    NCT00998907
    Conditions
    Wound Infection; Incisional Hernia
    Interventions
    PDS plus; PDS II
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2012-01
    Enrolment
    1,042

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Infection; Incisional Hernia
    InterventionPDS plus; PDS II
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Triclosan-coated Sutures in Cardiac Surgery

    NCT01212315 · start 2009-03

    Registered record
    Registry ID
    NCT01212315
    Conditions
    Postoperative Wound Infection
    Interventions
    Triclosan coated sutures
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-03
    Completion
    2012-06
    Enrolment
    392

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Wound Infection
    InterventionTriclosan coated sutures
    PhasePhase 4
    Registry statusCompleted

  • A Study of Different Use Regimens Using Two Acne Treatments

    NCT00907257 · start 2009-02

    Registered record
    Registry ID
    NCT00907257
    Conditions
    Acne Vulgaris
    Interventions
    benzoyl peroxide wash; Tretinoin gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-02
    Completion
    2009-09
    Enrolment
    247

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    Interventionbenzoyl peroxide wash; Tretinoin gel
    PhasePhase 4
    Registry statusCompleted

  • Coated VICRYL* Plus Suture Compared to Chinese Silk in Scheduled Breast Cancer Surgery

    NCT00768222 · start 2008-10

    Registered record
    Registry ID
    NCT00768222
    Conditions
    Breast Cancer
    Interventions
    silk suture; VICRYL* Plus suture
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-10
    Completion
    2009-05
    Enrolment
    101

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    Interventionsilk suture; VICRYL* Plus suture
    PhasePhase 4
    Registry statusCompleted

  • Effect on Bacterial Glycolytic Acid Formation on Plaque

    NCT00762450 · start 2008-04

    Registered record
    Registry ID
    NCT00762450
    Conditions
    Dental Plaque
    Interventions
    Triclosan, Fluoride; fluoride; Fluoride, triclosan, amino acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-04
    Completion
    2008-08
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionTriclosan, Fluoride; fluoride; Fluoride, triclosan, amino acid
    PhasePhase 3
    Registry statusCompleted