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AMR Drug RepurposingSmart Screeningresearch prototype

Triclosan

FDA-approved product (paste, dental).

Registered studies
50+
Lab records
8
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Triclosan
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Triclosan. Its therapeutic class is shown instead.

WHO therapeutic group
Phenol and derivatives; Medicated dressings with antiinfectives
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC D08AE04; WHO ATC D09AA06

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA64.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli81.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae68.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis84.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 2 of 2 lab records
  • K. pneumoniae: measured active in 1 of 2 lab records
  • M. tuberculosis: measured active in 2 of 2 lab records
Open Triclosan in ChEMBL Registered studies below
Show the 8 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triclosan with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Intervascular Post-Market Clinical Follow-Up (PMCF) Registry

    NCT07322913 · start 2025-12-19

    Registered record
    Registry ID
    NCT07322913
    Conditions
    Carotid Artery Diseases; Aortic Diseases; Peripheral Arterial Diseases
    Interventions
    Intergard Standard - Collagen Coated Vascular Grafts and Patches; Hemashield - Collagen Coated Vascular Grafts and Patches; Intergard Silver - Antimicrobial Collagen Coated Vascular Grafts and Patches; Intergard Synergy - Antimicrobial Collagen Coated Vascular Grafts
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2025-12-19
    Completion
    2027-07
    Enrolment
    1,200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarotid Artery Diseases; Aortic Diseases; Peripheral Arterial Diseases
    InterventionIntergard Standard - Collagen Coated Vascular Grafts and Patches; Hemashield - Collagen Coated Vascular Grafts and Patches; Intergard Silver - Antimicrobial Collagen Coated Vascular Grafts and Patches; Intergard Synergy - Antimicrobial Collagen Coated Vascular Grafts
    PhaseNot recorded
    Registry statusRecruiting

  • Soft Tissue Healing and Bacterial Load With Triclosan-Coated Sutures After Impacted Mandibular Third Molar Surgery

    NCT07386366 · start 2025-10-07

    Registered record
    Registry ID
    NCT07386366
    Conditions
    Impacted Mandibular Third Molar; Postoperative Wound Healing
    Interventions
    Triclosan-coated Polyglactin 910 suture; Non-coated polyglactin 910 suture
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-10-07
    Completion
    2026-03-31
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImpacted Mandibular Third Molar; Postoperative Wound Healing
    InterventionTriclosan-coated Polyglactin 910 suture; Non-coated polyglactin 910 suture
    PhaseNot applicable
    Registry statusCompleted

  • Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT

    NCT06043414 · start 2024-01-01

    Registered record
    Registry ID
    NCT06043414
    Conditions
    Laparotomy; Dehiscence Wound; Surgical Site Infections; Trauma Abdomen; Emergency General Surgery
    Interventions
    triclosan-coated barbed suture; triclosan-coated non-barbed suture; Non-coated non-barbed suture
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2024-01-01
    Completion
    2027-01-31
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparotomy; Dehiscence Wound; Surgical Site Infections; Trauma Abdomen +1 more
    Interventiontriclosan-coated barbed suture; triclosan-coated non-barbed suture; Non-coated non-barbed suture
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Study to Evaluate the Safety of Sebryl® and Sebryl Plus® in Seborrheic Dermatitis and Psoriasis of Scalp

    NCT05105139 · start 2021-11-29

    Registered record
    Registry ID
    NCT05105139
    Conditions
    Seborrheic Dermatitis; Psoriasis of Scalp
    Interventions
    Allantoin/ Coal Tar/ Clioquinol; Allantoin/ Coal Tar/ Clioquinol/ Triclosan
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-11-29
    Completion
    2022-02-25
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeborrheic Dermatitis; Psoriasis of Scalp
    InterventionAllantoin/ Coal Tar/ Clioquinol; Allantoin/ Coal Tar/ Clioquinol/ Triclosan
    PhaseNot recorded
    Registry statusCompleted

  • Triclosan-antibacterial Sutures Impact on the Incidence of Surgical Site Infection in Laparoscopic Surgeries.

    NCT04255927 · start 2020-02-05

    Registered record
    Registry ID
    NCT04255927
    Conditions
    Laparoscopic Surgery; Surgical Wound; Surgical Site Infection
    Interventions
    Coated Vicryl plus; Coated vicryl
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-02-05
    Completion
    2022-04-20
    Enrolment
    912

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparoscopic Surgery; Surgical Wound; Surgical Site Infection
    InterventionCoated Vicryl plus; Coated vicryl
    PhasePhase 4
    Registry statusCompleted

  • Triclosan-antibacterial Sutures Efficacy on the Incidence of Surgical Site Infection in Clean-contaminated Wounds

    NCT04256824 · start 2020-02-05

    Registered record
    Registry ID
    NCT04256824
    Conditions
    Surgical Site Infection; Surgical Wound; Surgical Wound Infection
    Interventions
    coated vicryl plus; Vicryl
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2020-02-05
    Completion
    2024-01-30
    Enrolment
    430

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection; Surgical Wound; Surgical Wound Infection
    Interventioncoated vicryl plus; Vicryl
    PhasePhase 4
    Registry statusUnknown

  • A Study of Two Types of Absorbable Surgical Sutures in the Suturing of Thyroid Surgery Incision

    NCT03792737 · start 2019-04-01

    Registered record
    Registry ID
    NCT03792737
    Conditions
    Sutures
    Interventions
    Spiral PDS Plus; Spiral MONOCRYL Plus; PDS Plus; MONOCRYL Plus; VICRYL Plus
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-04-01
    Completion
    2020-01-06
    Enrolment
    501

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSutures
    InterventionSpiral PDS Plus; Spiral MONOCRYL Plus; PDS Plus; MONOCRYL Plus +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Barbed Suture and Triclosan-coated Monofilament in Emergency Surgery

    NCT03763279 · start 2018-11-30

    Registered record
    Registry ID
    NCT03763279
    Conditions
    Surgical Site Infection
    Interventions
    Triclosan-coated barbed suture; Triclosan-coated monofilament suture; Monofilament suture
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-11-30
    Completion
    2019-03-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionTriclosan-coated barbed suture; Triclosan-coated monofilament suture; Monofilament suture
    PhasePhase 3
    Registry statusCompleted

  • FALCON Trial Testing Measures to Reduce Surgical Site Infection

    NCT03700749 · start 2018-11-29

    Registered record
    Registry ID
    NCT03700749
    Conditions
    Abdominal Surgery; Surgical Site Infection
    Interventions
    2% chlorhexidine + non-coated suture; 2% chlorhexidine + coated suture; 10%povidone-iodine + non-coated suture; 10%povidone-iodine + coated suture
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2018-11-29
    Completion
    2021-07-31
    Enrolment
    5,480

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbdominal Surgery; Surgical Site Infection
    Intervention2% chlorhexidine + non-coated suture; 2% chlorhexidine + coated suture; 10%povidone-iodine + non-coated suture; 10%povidone-iodine + coated suture
    PhasePhase 3
    Registry statusUnknown

  • Meta-analysis of Stannous Fluoride and the Effects on Dental Plaque

    NCT04006483 · start 2018-01-08

    Registered record
    Registry ID
    NCT04006483
    Conditions
    Dental Plaque
    Interventions
    Stannous fluoride dentifrice; Positive control dentifrice; Negative control dentifrice
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-01-08
    Completion
    2018-11-30
    Enrolment
    2,359

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionStannous fluoride dentifrice; Positive control dentifrice; Negative control dentifrice
    PhaseNot recorded
    Registry statusCompleted

  • Effect of a Combination of Bundles on Surgical-site Infection After Elective Colorectal Surgery

    NCT03081962 · start 2017-02-15

    Registered record
    Registry ID
    NCT03081962
    Conditions
    Surgical Site Infection
    Interventions
    Bundle; Standard care
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2017-02-15
    Completion
    2017-08
    Enrolment
    102

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionBundle; Standard care
    PhasePhase 3
    Registry statusUnknown

  • Efficacy of Triclosan-coated Sutures in the Episiotomy

    NCT02847936 · start 2016-07

    Registered record
    Registry ID
    NCT02847936
    Conditions
    Episiotomy
    Interventions
    vicryl plus suture; vicryl suture
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-07
    Completion
    2016-09
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpisiotomy
    Interventionvicryl plus suture; vicryl suture
    PhasePhase 4
    Registry statusUnknown

  • Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families.

    NCT03642353 · start 2016-01-30

    Registered record
    Registry ID
    NCT03642353
    Conditions
    Generalized Aggressive Periodontitis
    Interventions
    Triclosan; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-01-30
    Completion
    2016-12-20
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneralized Aggressive Periodontitis
    InterventionTriclosan; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers

    NCT02670135 · start 2015-06

    Registered record
    Registry ID
    NCT02670135
    Conditions
    Periodontal Disease; Systemic Inflammatory Markers
    Interventions
    Triclosan Containing Toothpaste; Triclosan Free Toothpaste
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-06
    Completion
    2016-08
    Enrolment
    303

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Disease; Systemic Inflammatory Markers
    InterventionTriclosan Containing Toothpaste; Triclosan Free Toothpaste
    PhasePhase 4
    Registry statusCompleted

  • The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis

    NCT02243046 · start 2014-12

    Registered record
    Registry ID
    NCT02243046
    Conditions
    Dental Plaque and Gingivitis
    Interventions
    Control toothpaste; Experimental toothpaste; Active Comparator
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-12
    Completion
    2015-05
    Enrolment
    162

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque and Gingivitis
    InterventionControl toothpaste; Experimental toothpaste; Active Comparator
    PhasePhase 2
    Registry statusCompleted