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AMR Drug RepurposingSmart Screeningresearch prototype

Triclosan

FDA-approved product (paste, dental).

Registered studies
50+
Lab records
8
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Triclosan
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Triclosan. Its therapeutic class is shown instead.

WHO therapeutic group
Phenol and derivatives; Medicated dressings with antiinfectives
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC D08AE04; WHO ATC D09AA06

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA64.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli81.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae68.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis84.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 2 of 2 lab records
  • K. pneumoniae: measured active in 1 of 2 lab records
  • M. tuberculosis: measured active in 2 of 2 lab records
Open Triclosan in ChEMBL Registered studies below
Show the 8 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triclosan with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Compare the Clinical Efficacy of Prototype Toothpastes.

    NCT00761930 · start 2008-03

    Registered record
    Registry ID
    NCT00761930
    Conditions
    Gingival Diseases
    Interventions
    Fluoride; Triclosan and fluoride; Herbal Ingredient and fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2008-06
    Enrolment
    103

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingival Diseases
    InterventionFluoride; Triclosan and fluoride; Herbal Ingredient and fluoride
    PhasePhase 3
    Registry statusCompleted

  • Collection of Gingival Crevicular Fluid From Periodontitis Patients

    NCT00763048 · start 2008-03

    Registered record
    Registry ID
    NCT00763048
    Conditions
    Gingival Diseases
    Interventions
    Fluoride; Fluoride, triclosan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2008-04
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingival Diseases
    InterventionFluoride; Fluoride, triclosan
    PhasePhase 3
    Registry statusCompleted

  • Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse

    NCT01024738 · start 2008-03

    Registered record
    Registry ID
    NCT01024738
    Conditions
    Dental Plaque
    Interventions
    Fluoride; Triclosan, fluoride; Chlorhexidine Gluconate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2008-04
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionFluoride; Triclosan, fluoride; Chlorhexidine Gluconate
    PhasePhase 3
    Registry statusCompleted

  • A Prospective Cohort Pilot Study of the Clinical and Molecular Epidemiology of Staphylococcus Aureus in Pregnant Women at the Time of Group B Streptococcal Screening in a Large Urban Medical Center in Chicago, IL USA

    NCT00532324 · start 2008-02

    Registered record
    Registry ID
    NCT00532324
    Conditions
    Staphylococcus Aureus
    Interventions
    CA-MRSA Decolonization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-02
    Completion
    2013-10
    Enrolment
    107

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionCA-MRSA Decolonization
    PhaseNot applicable
    Registry statusCompleted

  • Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes

    NCT00762515 · start 2008-02

    Registered record
    Registry ID
    NCT00762515
    Conditions
    Dental Plaque
    Interventions
    Fluoride; Triclosan; Fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-02
    Completion
    2008-08
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionFluoride; Triclosan; Fluoride
    PhasePhase 3
    Registry statusCompleted

  • Triclosan Toothpaste and Third Molar Surgery

    NCT01292343 · start 2008-02

    Registered record
    Registry ID
    NCT01292343
    Conditions
    Dry Socket; Wound Infection
    Interventions
    Colgate Total Toothpaste; Colgate Regular Toothpaste
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-02
    Completion
    2013-02
    Enrolment
    141

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDry Socket; Wound Infection
    InterventionColgate Total Toothpaste; Colgate Regular Toothpaste
    PhaseNot applicable
    Registry statusCompleted

  • Evaluate Clinical Research From Commerical Oral Care Products

    NCT00759187 · start 2008-01

    Registered record
    Registry ID
    NCT00759187
    Conditions
    Gingival Diseases
    Interventions
    Fluoride; Triclosan/Fluoride; Chlorhexidine Gluconate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-04
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingival Diseases
    InterventionFluoride; Triclosan/Fluoride; Chlorhexidine Gluconate
    PhasePhase 3
    Registry statusCompleted

  • Compare the Clinical Efficacy of Prototype Toothpastes

    NCT00926029 · start 2008-01

    Registered record
    Registry ID
    NCT00926029
    Conditions
    Dental Plaque
    Interventions
    Fluoride; Triclosan, fluoride; Metal salt
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-04
    Enrolment
    98

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionFluoride; Triclosan, fluoride; Metal salt
    PhasePhase 3
    Registry statusCompleted

  • Training and Calibration of Dental Examiners

    NCT00765167 · start 2007-11

    Registered record
    Registry ID
    NCT00765167
    Conditions
    Dental Plaque
    Interventions
    Fluoride; Triclosan; Chlorhexidine gluconate; Fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-11
    Completion
    2007-12
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionFluoride; Triclosan; Chlorhexidine gluconate; Fluoride
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Salivary Bacteria and Post Brushing

    NCT00981825 · start 2007-10

    Registered record
    Registry ID
    NCT00981825
    Conditions
    Salivary Bacteria Levels
    Interventions
    Fluoride; Triclosan/Fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-10
    Completion
    2007-12
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSalivary Bacteria Levels
    InterventionFluoride; Triclosan/Fluoride
    PhasePhase 3
    Registry statusCompleted

  • Effect of Triclosan-coated Suture on Superficial SSI

    NCT02018289 · start 2007-10

    Registered record
    Registry ID
    NCT02018289
    Conditions
    Surgical Site Infection
    Interventions
    Triclosan coated suture; No triclosan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-10
    Completion
    Not recorded
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionTriclosan coated suture; No triclosan
    PhasePhase 3
    Registry statusCompleted

  • Clinical Study to Compare Dental Plaque Control

    NCT00758394 · start 2007-09

    Registered record
    Registry ID
    NCT00758394
    Conditions
    Dental Plaque
    Interventions
    Fluoride; Triclosan/Fluoride; Triclosan/Fluoride; Triclosan/Fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-09
    Completion
    2007-11
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionFluoride; Triclosan/Fluoride; Triclosan/Fluoride; Triclosan/Fluoride
    PhasePhase 3
    Registry statusCompleted

  • Evaluating Commercial Anti-Plaque Products and Oral Rinse

    NCT01014143 · start 2007-08

    Registered record
    Registry ID
    NCT01014143
    Conditions
    Dental Plaque
    Interventions
    Fluoride; Chlorhexidine digluconate; Fluoride, triclosan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-08
    Completion
    2007-09
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Plaque
    InterventionFluoride; Chlorhexidine digluconate; Fluoride, triclosan
    PhasePhase 2
    Registry statusCompleted

  • To Access the Effects of Mucositis in Adults With Dental Implants

    NCT01072201 · start 2007-06

    Registered record
    Registry ID
    NCT01072201
    Conditions
    Mucositis
    Interventions
    Triclosan and Fluoride; Fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-06
    Completion
    2007-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMucositis
    InterventionTriclosan and Fluoride; Fluoride
    PhasePhase 3
    Registry statusCompleted

  • Clinical Study to Examine Brushing on Dental Implants

    NCT00762619 · start 2007-04

    Registered record
    Registry ID
    NCT00762619
    Conditions
    Gingival Diseases
    Interventions
    Fluoride; Triclosan, fluoride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-04
    Completion
    2008-08
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingival Diseases
    InterventionFluoride; Triclosan, fluoride
    PhasePhase 3
    Registry statusCompleted