Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Stavudine

FDA-approved product (capsule, oral), marketed as Stavudine, Zerit, Zerit Xr.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Stavudine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • HIV infection
  • HIV-1 infection
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nucleoside and nucleotide reverse transcriptase inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AF04

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Stavudine, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA13.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli14.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis22.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Stavudine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Stavudine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Lactate Metabolism Study in HIV Infected Persons

    NCT00202228 · start 2002-07

    Registered record
    Registry ID
    NCT00202228
    Conditions
    HIV Infections; AIDS; Lactic Acidosis; Lipodystrophy
    Interventions
    cofactor supplementation (thiamine, riboflavin, L-carnitine)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2002-07
    Completion
    2011-09
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; AIDS; Lactic Acidosis; Lipodystrophy
    Interventioncofactor supplementation (thiamine, riboflavin, L-carnitine)
    PhasePhase 4
    Registry statusCompleted

  • D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)

    NCT00143702 · start 2001-08

    Registered record
    Registry ID
    NCT00143702
    Conditions
    Acidosis, Lactic
    Interventions
    d4T; Abacavir; Riboflavin and Thiamine (Supplementation)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2001-08
    Completion
    2006-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcidosis, Lactic
    Interventiond4T; Abacavir; Riboflavin and Thiamine (Supplementation)
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Rollover Study for Zerit (Stavudine) ER Studies (-096, -099)

    NCT00116298 · start 2001-01

    Registered record
    Registry ID
    NCT00116298
    Conditions
    HIV Infections; AIDS
    Interventions
    stavudine, efavirenz, lamivudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2001-01
    Completion
    2005-01
    Enrolment
    900

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; AIDS
    Interventionstavudine, efavirenz, lamivudine
    PhasePhase 3
    Registry statusCompleted

  • Safety and Effectiveness of a Combination Anti-HIV Drug Treatment

    NCT00005018 · start 1999-07

    Registered record
    Registry ID
    NCT00005018
    Conditions
    HIV Infections
    Interventions
    Hydroxyurea; Abacavir sulfate; Efavirenz; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    1999-07
    Completion
    2000-10
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionHydroxyurea; Abacavir sulfate; Efavirenz; Didanosine
    PhasePhase 4
    Registry statusCompleted

  • Combination Drug Treatment of Pediatric HIV Infection

    NCT00001818 · start 1999-06

    Registered record
    Registry ID
    NCT00001818
    Conditions
    HIV Infection
    Interventions
    Hydroxyurea
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    1999-06
    Completion
    2001-11
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infection
    InterventionHydroxyurea
    PhasePhase 1
    Registry statusCompleted

  • A Study to Compare the Safety and Effectiveness of Two Dosing Schedules of Lamivudine in Combination With Two Other Anti-HIV Drugs

    NCT00002442 · start 1999-06

    Registered record
    Registry ID
    NCT00002442
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Nelfinavir mesylate; Lamivudine; Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1999-06
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Nelfinavir mesylate; Lamivudine; Stavudine
    PhasePhase 2
    Registry statusCompleted

  • Five-Drug Anti-HIV Treatment Followed by Treatment Interruption in Patients Who Have Recently Been Infected With HIV

    NCT00000940 · start 1999-05

    Registered record
    Registry ID
    NCT00000940
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Abacavir sulfate; Amprenavir; Lamivudine; Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1999-05
    Completion
    2006-10
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Abacavir sulfate; Amprenavir; Lamivudine +1 more
    PhasePhase 2
    Registry statusCompleted

  • A Comparison of Two Triple-Drug Combinations in Patients Who Have Never Been Treated With Anti-HIV Drugs

    NCT00002411 · start 1998-03

    Registered record
    Registry ID
    NCT00002411
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate; Lamivudine; Stavudine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1998-03
    Completion
    1999-09
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate; Lamivudine; Stavudine; Zidovudine +1 more
    PhaseNot applicable
    Registry statusCompleted

  • A Pilot Study of the Immunologic Reconstitution in HIV-1 Infected Children Receiving Highly Active Antiretroviral Therapy With Combination Ritonavir, Nevirapine and Stavudine

    NCT00001688 · start 1998-01

    Registered record
    Registry ID
    NCT00001688
    Conditions
    HIV Infection
    Interventions
    Ritonavir; Nevirapine; Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1998-01
    Completion
    2001-11
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infection
    InterventionRitonavir; Nevirapine; Stavudine
    PhasePhase 2
    Registry statusCompleted

  • A Study to Evaluate the Use of Stavudine (d4T) to Treat AIDS Dementia Complex

    NCT00002246 · start 1997-10

    Registered record
    Registry ID
    NCT00002246
    Conditions
    AIDS Dementia Complex; HIV Infections
    Interventions
    Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1997-10
    Completion
    1999-03
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAIDS Dementia Complex; HIV Infections
    InterventionStavudine
    PhasePhase 3
    Registry statusCompleted

  • A Pilot Study to Compare the Antiviral and Immunologic Effects of Stavudine ( d4T ) Versus Placebo in Subjects With Evidence of Recent HIV Infection.

    NCT00002349 · start 1995-01

    Registered record
    Registry ID
    NCT00002349
    Conditions
    HIV Infections
    Interventions
    Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1995-01
    Completion
    1999-05
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionStavudine
    PhaseNot applicable
    Registry statusCompleted

  • A Study of d4T in Patients With AIDS or AIDS-Related Complex Who Cannot Take AZT

    NCT00000686

    Registered record
    Registry ID
    NCT00000686
    Conditions
    HIV Infections
    Interventions
    Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionStavudine
    PhasePhase 1
    Registry statusTerminated

  • A Randomized, Comparative Trial of Zidovudine (AZT) Versus 2',3'-Didehydro-3'-Deoxythymidine (Stavudine; d4T) in Children With HIV Infection

    NCT00000789

    Registered record
    Registry ID
    NCT00000789
    Conditions
    HIV Infections
    Interventions
    Stavudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1998-07
    Enrolment
    230

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionStavudine; Zidovudine
    PhasePhase 2
    Registry statusCompleted

  • Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine

    NCT00000838

    Registered record
    Registry ID
    NCT00000838
    Conditions
    HIV Infections
    Interventions
    Lamivudine; Stavudine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1998-03
    Enrolment
    256

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionLamivudine; Stavudine; Zidovudine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • A Study to Evaluate the Safety and Tolerance of Stavudine (d4T) in Combination With Lamivudine (3TC) in HIV-Positive Pregnant Women and Their Infants

    NCT00000878

    Registered record
    Registry ID
    NCT00000878
    Conditions
    HIV Infections; Pregnancy
    Interventions
    Lamivudine; Stavudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2001-10
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Pregnancy
    InterventionLamivudine; Stavudine; Zidovudine
    PhasePhase 1
    Registry statusCompleted