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AMR Drug RepurposingSmart Screeningresearch prototype

Oxytocin

FDA-approved product (solution, nasal), marketed as Oxytocin, Oxytocin 10 Usp Units In Dextrose 5%, Oxytocin 20 Usp Units In Dextrose 5% and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Oxytocin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage
  • Uterine Inertia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Oxytocin and analogues
FDA pharmacologic class
Oxytocic FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA74.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae52.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Oxytocin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Oxytocin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Ocytocine and Cerebral Activation in Relation With Attachement

    NCT02847143 · start 2015-04-09

    Registered record
    Registry ID
    NCT02847143
    Conditions
    Attachement Style
    Interventions
    nasal oxytocin or placebo; fMRI; Attachement scale interview (ASI); psychometric scales
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-04-09
    Completion
    2018-04-27
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAttachement Style
    Interventionnasal oxytocin or placebo; fMRI; Attachement scale interview (ASI); psychometric scales
    PhasePhase 2
    Registry statusCompleted

  • Foley With Oxytocin Versus Foley no Oxytocin for Induction of Labor

    NCT02273115 · start 2014-10

    Registered record
    Registry ID
    NCT02273115
    Conditions
    Labor; Forced or Induced, Affecting Fetus or Newborn
    Interventions
    Oxytocin; Transcervical Foley catheter
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-10
    Completion
    2016-09-11
    Enrolment
    323

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLabor; Forced or Induced, Affecting Fetus or Newborn
    InterventionOxytocin; Transcervical Foley catheter
    PhasePhase 4
    Registry statusCompleted

  • Oxytocin for Couples Conflict Resolution

    NCT02941692 · start 2014-06

    Registered record
    Registry ID
    NCT02941692
    Conditions
    Substance Misuse; Interpersonal Conflict; Neuroendocrine Reactivity
    Interventions
    Oxytocin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-06
    Completion
    2017-03
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubstance Misuse; Interpersonal Conflict; Neuroendocrine Reactivity
    InterventionOxytocin; Placebo
    PhasePhase 2
    Registry statusCompleted

  • A Randomized Trial Comparing Oxytocin and Oxytocin + Ergometrine for Prevention of Postpartum Haemorrhage at Caesarean Section

    NCT02046499 · start 2014-01-01

    Registered record
    Registry ID
    NCT02046499
    Conditions
    Prevention of Post Partum Haemorrhage
    Interventions
    Oxytocin; Oxytocin ergometrine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-01-01
    Completion
    2014-09-30
    Enrolment
    540

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrevention of Post Partum Haemorrhage
    InterventionOxytocin; Oxytocin ergometrine
    PhaseNot applicable
    Registry statusCompleted

  • Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic Prophylaxis

    NCT02985086 · start 2013-07

    Registered record
    Registry ID
    NCT02985086
    Conditions
    Maternal Infection During Pregnancy (Diagnosis); Neonatal Infection
    Interventions
    Cefoxitin; oxytocin/misoprostol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2013-07
    Completion
    2018-07
    Enrolment
    568

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMaternal Infection During Pregnancy (Diagnosis); Neonatal Infection
    InterventionCefoxitin; oxytocin/misoprostol
    PhaseNot applicable
    Registry statusUnknown

  • Oxytocin in Opiate Dependence: A Pilot Study of the Effects of Intranasal Oxytocin on Emotional Processes and Stress Responses in Patients With Opiate Dependence

    NCT02052258 · start 2013-01

    Registered record
    Registry ID
    NCT02052258
    Conditions
    Opiate Dependence
    Interventions
    Oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2013-01
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpiate Dependence
    InterventionOxytocin
    PhasePhase 1
    Registry statusUnknown

  • The Effect of Oxytocin on Placebo Analgesia: an Experimental Study in Healthy Volunteers

    NCT01886014 · start 2012-01

    Registered record
    Registry ID
    NCT01886014
    Conditions
    Mechanisms and Modulators of Placebo Analgesia in Healthy Volunteers
    Interventions
    Oxytocin; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-01
    Completion
    2012-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMechanisms and Modulators of Placebo Analgesia in Healthy Volunteers
    InterventionOxytocin; placebo
    PhaseNot applicable
    Registry statusCompleted

  • Safety Study of Intranasal Oxytocin in Frontotemporal Dementia

    NCT01386333 · start 2011-06

    Registered record
    Registry ID
    NCT01386333
    Conditions
    Frontotemporal Dementia
    Interventions
    oxytocin; Saline Nasal Mist
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-06
    Completion
    Not recorded
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFrontotemporal Dementia
    Interventionoxytocin; Saline Nasal Mist
    PhasePhase 1
    Registry statusCompleted

  • Does Acute Oxytocin Administration Enhance Social Cognition in Individuals With Schizophrenia?

    NCT01312272 · start 2011-04

    Registered record
    Registry ID
    NCT01312272
    Conditions
    Schizophrenia
    Interventions
    Oxytocin; Inactive placebo nasal spray
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-04
    Completion
    2012-08
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionOxytocin; Inactive placebo nasal spray
    PhaseNot applicable
    Registry statusCompleted

  • A Study of Oxytocin in Children and Adolescents With Autistic Disorder

    NCT01308749 · start 2011-03

    Registered record
    Registry ID
    NCT01308749
    Conditions
    Autism
    Interventions
    Oxytocin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-03
    Completion
    2013-04
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutism
    InterventionOxytocin; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Oxytocin Add-on for Stable Depressed Patients

    NCT01211756 · start 2010-10

    Registered record
    Registry ID
    NCT01211756
    Conditions
    Major Depressive Disorder; Dysthymia Disorder
    Interventions
    Oxytocin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-10
    Completion
    2015-12
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Dysthymia Disorder
    InterventionOxytocin; Placebo
    PhaseNot applicable
    Registry statusTerminated

  • Effects of MDMA on Social and Emotional Processing

    NCT01849419 · start 2010-07

    Registered record
    Registry ID
    NCT01849419
    Conditions
    Drug Addiction
    Interventions
    Within-subjects (MDMA); Within-subjects (oxytocin); Within-subjects (placebo)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-07
    Completion
    2013-03
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Addiction
    InterventionWithin-subjects (MDMA); Within-subjects (oxytocin); Within-subjects (placebo)
    PhaseNot applicable
    Registry statusCompleted

  • Gestational Diabetes: Induction Versus Expectant Management of Labour

    NCT01058772 · start 2010-03

    Registered record
    Registry ID
    NCT01058772
    Conditions
    Gestational Diabetes; Gestational Diabetes Mellitus; Diabetes Mellitus, Gestational; Pregnancy-Induced Diabetes; Diabetes, Pregnancy Induced
    Interventions
    INDUCTION of LABOUR
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-03
    Completion
    2014-03
    Enrolment
    425

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGestational Diabetes; Gestational Diabetes Mellitus; Diabetes Mellitus, Gestational; Pregnancy-Induced Diabetes +1 more
    InterventionINDUCTION of LABOUR
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Intranasal Oxytocin on Headache in Chronic Daily Headache

    NCT00963040 · start 2009-11

    Registered record
    Registry ID
    NCT00963040
    Conditions
    Chronic Daily Headache
    Interventions
    Syntocinon; Sterile water; Syntocinon; Sterile water
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-11
    Completion
    2010-08
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Daily Headache
    InterventionSyntocinon; Sterile water; Syntocinon; Sterile water
    PhaseNot applicable
    Registry statusCompleted

  • Oxytocin Treatment of Schizophrenia

    NCT01028677 · start 2009-11

    Registered record
    Registry ID
    NCT01028677
    Conditions
    Paranoia; Schizophrenia; Schizoaffective Disorder
    Interventions
    intranasal spray with oxytocin; nasal spray without oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-11
    Completion
    2011-03
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParanoia; Schizophrenia; Schizoaffective Disorder
    Interventionintranasal spray with oxytocin; nasal spray without oxytocin
    PhaseNot applicable
    Registry statusCompleted