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AMR Drug RepurposingSmart Screeningresearch prototype

Oxytocin

FDA-approved product (solution, nasal), marketed as Oxytocin, Oxytocin 10 Usp Units In Dextrose 5%, Oxytocin 20 Usp Units In Dextrose 5% and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Oxytocin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Hemorrhage
  • Uterine Inertia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Oxytocin and analogues
FDA pharmacologic class
Oxytocic FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA74.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae52.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Oxytocin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Oxytocin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Maintenance Infusion of Oxytocin Following Elective Cesarean Deliveries

    NCT04946006 · start 2021-07-26

    Registered record
    Registry ID
    NCT04946006
    Conditions
    Postpartum Hemorrhage
    Interventions
    Oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-07-26
    Completion
    2022-04-02
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostpartum Hemorrhage
    InterventionOxytocin
    PhaseNot applicable
    Registry statusCompleted

  • Tranexamic Acid in the Prevention of Postpartum Hemorrhage in Elective Caesarean Section

    NCT04427618 · start 2020-06-23

    Registered record
    Registry ID
    NCT04427618
    Conditions
    Postpartum Hemorrhage; Tranexamic Acid
    Interventions
    Tranexamic acid; Normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2020-06-23
    Completion
    2022-02-01
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostpartum Hemorrhage; Tranexamic Acid
    InterventionTranexamic acid; Normal saline
    PhasePhase 3
    Registry statusCompleted

  • Oral Oxytocin Modulation of Responses to Emotional Stimuli

    NCT04320706 · start 2020-02-20

    Registered record
    Registry ID
    NCT04320706
    Conditions
    Healthy
    Interventions
    Oral Oxytocin; Oral Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-02-20
    Completion
    2021-03-01
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionOral Oxytocin; Oral Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Oxytocin at Elective Cesarean Deliveries: A Dose-finding Study in Women With Twin Pregnancy

    NCT04025658 · start 2019-08-06

    Registered record
    Registry ID
    NCT04025658
    Conditions
    Postpartum Hemorrhage; Twin
    Interventions
    Oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-08-06
    Completion
    2021-09-08
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostpartum Hemorrhage; Twin
    InterventionOxytocin
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Labor Induction With Oxytocin on Early Postpartum Hemorrhage, Perineal Integrity and Breastfeeding

    NCT04441125 · start 2019-06-01

    Registered record
    Registry ID
    NCT04441125
    Conditions
    Oxytocin
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2019-06-01
    Completion
    2020-09-20
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOxytocin
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy

    NCT04109339 · start 2019-05-01

    Registered record
    Registry ID
    NCT04109339
    Conditions
    Oxytocin; Hemodynamic Monitoring; Laparoscopic Surgery
    Interventions
    Oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2019-05-01
    Completion
    2020-10-01
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOxytocin; Hemodynamic Monitoring; Laparoscopic Surgery
    InterventionOxytocin
    PhaseNot applicable
    Registry statusUnknown

  • Oxytocin in MRI-HIFU

    NCT03937401 · start 2019-02-01

    Registered record
    Registry ID
    NCT03937401
    Conditions
    Fibroid; Adenomyosis
    Interventions
    Oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-02-01
    Completion
    2021-01-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFibroid; Adenomyosis
    InterventionOxytocin
    PhasePhase 4
    Registry statusUnknown

  • Differential Effects of Oral and Intranasal Oxytocin on Attention Control

    NCT04815395 · start 2017-12-19

    Registered record
    Registry ID
    NCT04815395
    Conditions
    Healthy
    Interventions
    Oxytocin; Oxytocin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-12-19
    Completion
    2021-01-01
    Enrolment
    151

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionOxytocin; Oxytocin; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Bilateral Uterine Artery Ligation in Reducing Incidence of Postpartum Hemorrhage in Cesarean Section

    NCT03591679 · start 2017-12-01

    Registered record
    Registry ID
    NCT03591679
    Conditions
    Post Partum Hemorrhage
    Interventions
    Oxytocin; bilateral uterine artery ligation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-12-01
    Completion
    2019-01-01
    Enrolment
    1,070

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Partum Hemorrhage
    InterventionOxytocin; bilateral uterine artery ligation
    PhaseNot applicable
    Registry statusCompleted

  • Intraumbilical Oxytocin Versus Placental Cord Drainage in the Management of 3rd Stage of Labor

    NCT03395730 · start 2017-09-30

    Registered record
    Registry ID
    NCT03395730
    Conditions
    Postpartum Haemorrhage With Retained Placenta
    Interventions
    Intraumbilical vein injection oxytocin; placental cord drainage; Expectant managment of 3rd stage of labour
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2017-09-30
    Completion
    2018-01-30
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostpartum Haemorrhage With Retained Placenta
    InterventionIntraumbilical vein injection oxytocin; placental cord drainage; Expectant managment of 3rd stage of labour
    PhasePhase 2
    Registry statusUnknown

  • Oxytocin Infusion and Abdominal Myomectomy

    NCT03702946 · start 2017-07-15

    Registered record
    Registry ID
    NCT03702946
    Conditions
    Oxytocin and Abdominal Myomectomy
    Interventions
    oxytocin in abdominal myomectomy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-07-15
    Completion
    2018-01-15
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOxytocin and Abdominal Myomectomy
    Interventionoxytocin in abdominal myomectomy
    PhasePhase 3
    Registry statusCompleted

  • Empathy, Psychopathy and Autism: Behavioural Associations and the Role of an Oxytocin Receptor Polymorphism in a Non-clinical Adult Population

    NCT04746027 · start 2017-07-01

    Registered record
    Registry ID
    NCT04746027
    Conditions
    Empathy; Autism; Psychopathy
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-07-01
    Completion
    2018-11-01
    Enrolment
    126

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEmpathy; Autism; Psychopathy
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Multiple Dose Effect of Oxytocin on Males With High or Low Trait Anxiety

    NCT03085654 · start 2017-03-03

    Registered record
    Registry ID
    NCT03085654
    Conditions
    Healthy
    Interventions
    Oxytocin nasal spray; Placebo nasal spray
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2017-03-03
    Completion
    2018-04-30
    Enrolment
    147

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionOxytocin nasal spray; Placebo nasal spray
    PhaseEarly phase 1
    Registry statusCompleted

  • Prenatal Cocaine, Nasal Oxytocin, and Maternal Psychophysiology

    NCT02872467 · start 2016-05

    Registered record
    Registry ID
    NCT02872467
    Conditions
    Substance Abuse Problem; Pregnancy
    Interventions
    Syntocinon treatment; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-05
    Completion
    2023-03
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubstance Abuse Problem; Pregnancy
    InterventionSyntocinon treatment; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Outcomes After the Implementation of a New Oxytocin Protocol

    NCT02722356 · start 2016-04

    Registered record
    Registry ID
    NCT02722356
    Conditions
    Complications; Cesarean Section; Adverse Reaction to Oxytocin
    Interventions
    Oxytocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-04
    Completion
    2017-02-28
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplications; Cesarean Section; Adverse Reaction to Oxytocin
    InterventionOxytocin
    PhaseNot applicable
    Registry statusCompleted