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AMR Drug RepurposingSmart Screeningresearch prototype

Prednisone

FDA-approved product (tablet, oral), marketed as Cortan, Delta-Dome, Deltasone and 10 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Prednisone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Adrenal gland disease
  • Allergic conjunctivitis
  • Allergic rhinitis
  • Anemia
  • Ankylosing spondylitis
  • Aplastic anemia
  • Arthritis
  • Asthma
  • Atopic eczema
  • Autoimmune thrombocytopenic purpura
  • Berylliosis
  • Brain neoplasm
  • Bursitis
  • Cancer
  • Chorioretinitis
  • Choroiditis
  • and 60 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids acting locally; Corticosteroids; Corticosteroids, weak (group i); Corticosteroids, weak, other combinations
FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli30.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis35.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Prednisone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Prednisone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Phase II Randomized Trial of Radiation Therapy in Oligometastatic mCRPC Prostate Cancer (ARTO)

    NCT03449719 · start 2018-05-01

    Registered record
    Registry ID
    NCT03449719
    Conditions
    Rate of PSA Response in Oligometastatic,CRPC Undergoing SBRT in Combination With Abiraterone Acetate (AA), Compared to Patients Treated With AA Alone
    Interventions
    SBRT - Ablative radiation Therapy; Abiraterone Acetate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-05-01
    Completion
    2022-05-01
    Enrolment
    174

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRate of PSA Response in Oligometastatic,CRPC Undergoing SBRT in Combination With Abiraterone Acetate (AA), Compared to Patients Treated With AA Alone
    InterventionSBRT - Ablative radiation Therapy; Abiraterone Acetate
    PhaseNot applicable
    Registry statusUnknown

  • Dexamethasone Versus Prednisone for Asthma Treatment in the Pediatric Inpatient Population; a Feasibility Study

    NCT03133897 · start 2018-03-05

    Registered record
    Registry ID
    NCT03133897
    Conditions
    Asthma
    Interventions
    Dexamethasone; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2018-03-05
    Completion
    2020-03-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionDexamethasone; Prednisone
    PhasePhase 3
    Registry statusTerminated

  • Thalidomide Combined With R-CHOP in Newly Diagnosed，Untreated Double-expressor Diffuse Large B-Cell Lymphoma Patients

    NCT03318835 · start 2017-08-22

    Registered record
    Registry ID
    NCT03318835
    Conditions
    Thalidomide
    Interventions
    Thalidomide combined with R-CHOP; R-CHOP
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2017-08-22
    Completion
    2020-08-22
    Enrolment
    162

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThalidomide
    InterventionThalidomide combined with R-CHOP; R-CHOP
    PhasePhase 3
    Registry statusUnknown

  • Safety and Efficacy of Blinatumomab in Adults With Newly Diagnosed High-risk Diffuse Large B-Cell Lymphoma

    NCT03023878 · start 2017-03-13

    Registered record
    Registry ID
    NCT03023878
    Conditions
    High-risk Diffuse Large B-Cell Lymphoma
    Interventions
    Blinatumomab; Investigator's Choice Chemotherapy; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-03-13
    Completion
    2019-10-28
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh-risk Diffuse Large B-Cell Lymphoma
    InterventionBlinatumomab; Investigator's Choice Chemotherapy; Dexamethasone
    PhasePhase 2
    Registry statusCompleted

  • Cinobufacini Tablets Combined With Chemotherapeutic Protocol in Treatment of Diffuse Large B Cell Lymphoma

    NCT02871869 · start 2016-09

    Registered record
    Registry ID
    NCT02871869
    Conditions
    Diffuse, Large B-Cell, Lymphoma
    Interventions
    vindesine; cyclophosphamide; Epirubicin; prednisone tablets; Cinobufacini Tablets; Rituximab
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2016-09
    Completion
    2021-12
    Enrolment
    316

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiffuse, Large B-Cell, Lymphoma
    Interventionvindesine; cyclophosphamide; Epirubicin; prednisone tablets +2 more
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • The Efficacy of TCD Following by TP Maintenance Therapy in Newly Diagnosed WM

    NCT02844309 · start 2016-05

    Registered record
    Registry ID
    NCT02844309
    Conditions
    Waldenström Macroglobulinemia
    Interventions
    Thalidomide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-05
    Completion
    2020-05
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWaldenström Macroglobulinemia
    InterventionThalidomide
    PhasePhase 4
    Registry statusCompleted

  • Corticosteroids With Vedolizumab in Crohn's Disease

    NCT02324699 · start 2016-04

    Registered record
    Registry ID
    NCT02324699
    Conditions
    Crohn's Disease
    Interventions
    Prednisone; Placebo; Vedolizumab
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2016-04
    Completion
    2018-02-08
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCrohn's Disease
    InterventionPrednisone; Placebo; Vedolizumab
    PhasePhase 4
    Registry statusTerminated

  • Initiation of a Deceased Donor Uterine Transplantation Program at the University of Nebraska Medical Center

    NCT02409147 · start 2016-01

    Registered record
    Registry ID
    NCT02409147
    Conditions
    Uterus Transplant
    Interventions
    Uterine Transplant
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2016-01
    Completion
    2018-07-24
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterus Transplant
    InterventionUterine Transplant
    PhaseNot applicable
    Registry statusWithdrawn

  • Repeat Emergency Department Visits Among Patients With Asthma and COPD

    NCT02499887 · start 2016-01

    Registered record
    Registry ID
    NCT02499887
    Conditions
    Asthma; COPD
    Interventions
    beclamethasone dipropionate; albuterol; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2016-01
    Completion
    2016-09
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma; COPD
    Interventionbeclamethasone dipropionate; albuterol; Prednisone
    PhaseNot applicable
    Registry statusTerminated

  • Treatment for Classical Hodgkin Lymphoma in Children and Adolescents

    NCT02797717 · start 2015-11

    Registered record
    Registry ID
    NCT02797717
    Conditions
    Classical Hodgkins Lymphoma in Children and Adolescents.
    Interventions
    Radiotherapy:; Vincristine; Etoposide; Prednisone; Doxorubicin; Dacarbazine; Cyclophosphamide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2015-11
    Completion
    2027-12
    Enrolment
    2,200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClassical Hodgkins Lymphoma in Children and Adolescents.
    InterventionRadiotherapy:; Vincristine; Etoposide; Prednisone +3 more
    PhaseNot applicable
    Registry statusRecruiting

  • Glucocorticoid in Treatment of Adult Idiopathic Nephrotic Syndrome：a Prospective Observational Study

    NCT02298335 · start 2014-05-13

    Registered record
    Registry ID
    NCT02298335
    Conditions
    Nephrotic Syndrome，Idiopathic
    Interventions
    prednisone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-05-13
    Completion
    2020-10-22
    Enrolment
    235

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNephrotic Syndrome，Idiopathic
    Interventionprednisone
    PhaseNot applicable
    Registry statusCompleted

  • Treatment With a Scheme With Low Doses of Bortezomib / Melphalan / Prednisone (MPV) in Patients With Multiple Myeloma

    NCT02773550 · start 2014-01

    Registered record
    Registry ID
    NCT02773550
    Conditions
    Multiple Myeloma
    Interventions
    Bortezomib; Melphalan; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2014-01
    Completion
    2018-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Myeloma
    InterventionBortezomib; Melphalan; Prednisone
    PhasePhase 4
    Registry statusTerminated

  • Short-term Prednisone to Treat STA Study(SPTSS)

    NCT01837433 · start 2013-03

    Registered record
    Registry ID
    NCT01837433
    Conditions
    Subacute Thyroiditis
    Interventions
    Prednisone 1 week; Prednisone 6 weeks
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-03
    Completion
    2014-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubacute Thyroiditis
    InterventionPrednisone 1 week; Prednisone 6 weeks
    PhasePhase 4
    Registry statusCompleted

  • Postoperative Systemic Corticosteroids When Utilizing a Steroid-Eluting Spacer Following Endoscopic Sinus Surgery

    NCT01564355 · start 2012-04

    Registered record
    Registry ID
    NCT01564355
    Conditions
    Chronic Sinusitis; Endoscopic Sinus Surgery; Post-operative Care; Steroids; Drug-eluting Spacer
    Interventions
    Steroid-eluting middle meatal spacer (Nasopore (TM) spacer impregnated with 1 cc of 40mg/mL triamcinolone liquid); Post-op Oral Steroids
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-04
    Completion
    2013-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Sinusitis; Endoscopic Sinus Surgery; Post-operative Care; Steroids +1 more
    InterventionSteroid-eluting middle meatal spacer (Nasopore (TM) spacer impregnated with 1 cc of 40mg/mL triamcinolone liquid); Post-op Oral Steroids
    PhaseNot applicable
    Registry statusCompleted

  • The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease

    NCT01469702 · start 2011-12

    Registered record
    Registry ID
    NCT01469702
    Conditions
    Cat-scratch Disease; Bartonella Infections
    Interventions
    prednison and azithromycin; prednison, azithromycin; prednison, Azenil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-12
    Completion
    Not recorded
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCat-scratch Disease; Bartonella Infections
    Interventionprednison and azithromycin; prednison, azithromycin; prednison, Azenil
    PhasePhase 4
    Registry statusUnknown