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AMR Drug RepurposingSmart Screeningresearch prototype

Atorvastatin Calcium

FDA-approved product (tablet, oral), marketed as Atorvaliq, Atorvastatin Calcium, Lipitor.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Atorvastatin Calcium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Abnormal circulating lipid concentration
  • Acute myocardial infarction
  • Angina pectoris
  • Cardiovascular disease
  • Congestive heart failure
  • Coronary artery disease
  • Familial hypercholesterolemia
  • Heart failure
  • Hypercholesterolemia
  • Hyperlipidemia
  • Hypertension
  • Myocardial infarction
  • Stroke

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Hmg coa reductase inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA41.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli25.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae15.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis61.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Atorvastatin Calcium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Atorvastatin Calcium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of Safety and Efficacy of MK0859 (Anacetrapib) in Japanese Patients With Dyslipidemia (0859-029)

    NCT00977288 · start 2009-09

    Registered record
    Registry ID
    NCT00977288
    Conditions
    Dyslipidemia
    Interventions
    anacetrapib; Comparator: atorvastatin; Comparator: Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-09
    Completion
    2014-04
    Enrolment
    408

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyslipidemia
    Interventionanacetrapib; Comparator: atorvastatin; Comparator: Placebo
    PhasePhase 2
    Registry statusCompleted

  • Statin Interchange by Pharmacist Collaborative Practice Agreement (CPA)

    NCT01222182 · start 2009-09

    Registered record
    Registry ID
    NCT01222182
    Conditions
    Hypercholesterolemia
    Interventions
    atorvastatin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-09
    Completion
    2011-06
    Enrolment
    260

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    Interventionatorvastatin
    PhaseNot recorded
    Registry statusCompleted

  • Effect of CYP3A Genetic Polymorphisms on the Pharmacokinetics of Atorvastatin

    NCT00973986 · start 2009-06

    Registered record
    Registry ID
    NCT00973986
    Conditions
    Coronary Heart Disease
    Interventions
    Atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-06
    Completion
    2011-03
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Heart Disease
    InterventionAtorvastatin
    PhasePhase 1
    Registry statusCompleted

  • Efficacy and Safety of Prescription Omega-3 Fatty Acid Added to Stable Statin Therapy in Patients With Type 2 Diabetes and Hypertriglyceridemia

    NCT02305355 · start 2009-02

    Registered record
    Registry ID
    NCT02305355
    Conditions
    Diabetes Mellitus, Type 2; Hypertriglycemia
    Interventions
    Omega-3-acids ethylesters 90 4g; Pravastatin, Simvastatin, Atorvastatin, Rosuvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-02
    Completion
    2011-02
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus, Type 2; Hypertriglycemia
    InterventionOmega-3-acids ethylesters 90 4g; Pravastatin, Simvastatin, Atorvastatin, Rosuvastatin
    PhasePhase 4
    Registry statusCompleted

  • The Use of Statins Following a Left Atrial Catheter Ablation Procedure to Prevent Atrial Fibrillation

    NCT00579098 · start 2007-12

    Registered record
    Registry ID
    NCT00579098
    Conditions
    Atrial Fibrillation; Arrhythmia; Inflammation; Endothelial Dysfunction
    Interventions
    Atorvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-12
    Completion
    2011-12
    Enrolment
    125

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Arrhythmia; Inflammation; Endothelial Dysfunction
    InterventionAtorvastatin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Safety FollowUp Study Of Cardiovascular Events In Subjects Who Participated In Selected Torcetrapib/Atorvastatin Studies

    NCT00452842 · start 2007-10

    Registered record
    Registry ID
    NCT00452842
    Conditions
    Cardiovascular Disease; Cerebrovascular Disorders
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2007-10
    Completion
    Not recorded
    Enrolment
    26,784

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Disease; Cerebrovascular Disorders
    InterventionNot recorded
    PhaseNot recorded
    Registry statusTerminated

  • Lipitor Korean Atorvastatin Goal Achievement Across Risk Levels Study

    NCT00540293 · start 2007-10

    Registered record
    Registry ID
    NCT00540293
    Conditions
    Dyslipidemias
    Interventions
    Atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-10
    Completion
    2008-05
    Enrolment
    425

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyslipidemias
    InterventionAtorvastatin
    PhasePhase 4
    Registry statusCompleted

  • A Randomized Study To Evaluate Efficacy And Safety Of A Fixed Combination Therapy Of Amlodipine And Atorvastatin

    NCT00530946 · start 2007-09

    Registered record
    Registry ID
    NCT00530946
    Conditions
    Hypertension; Hypercholesterolemia
    Interventions
    Amlodipine 2.5mg/Atorvastatin 5mg; Amlodipine 2.5mg/Atorvastatin 10mg; Amlodipine 5mg/Atorvastatin 5mg; Amlodipine 5mg/Atorvastatin 10mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-09
    Completion
    2008-04
    Enrolment
    165

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Hypercholesterolemia
    InterventionAmlodipine 2.5mg/Atorvastatin 5mg; Amlodipine 2.5mg/Atorvastatin 10mg; Amlodipine 5mg/Atorvastatin 5mg; Amlodipine 5mg/Atorvastatin 10mg
    PhasePhase 3
    Registry statusCompleted

  • EASEGO Study: Doubling of Atorvastatin/Simvastatin or INEGY in Patients With Hypercholesterolemia and Coronary Artery Disease(CAD)(0653A-089)

    NCT00166530 · start 2005-11

    Registered record
    Registry ID
    NCT00166530
    Conditions
    Atherosclerosis
    Interventions
    ezetimibe (+) simvastatin; simvastatin; atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-11
    Completion
    2007-02
    Enrolment
    367

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtherosclerosis
    Interventionezetimibe (+) simvastatin; simvastatin; atorvastatin
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Lapaquistat Acetate and Atorvastatin on Blood Cholesterol Levels in Subjects With Primary Hypercholesterolemia

    NCT00143676 · start 2005-08

    Registered record
    Registry ID
    NCT00143676
    Conditions
    Hypercholesterolemia
    Interventions
    Lapaquistat acetate and atorvastatin; Lapaquistat acetate and atorvastatin; Atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-08
    Completion
    2006-08
    Enrolment
    448

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionLapaquistat acetate and atorvastatin; Lapaquistat acetate and atorvastatin; Atorvastatin
    PhasePhase 3
    Registry statusCompleted

  • Optimalization of Nephroprotection Using Atorvastatin (Sortis)

    NCT00572312 · start 2005-02

    Registered record
    Registry ID
    NCT00572312
    Conditions
    Chronic Kidney Disease; Proteinuria
    Interventions
    atorvastatin (Sortis) 40 mg
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-02
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease; Proteinuria
    Interventionatorvastatin (Sortis) 40 mg
    PhaseNot applicable
    Registry statusCompleted

  • Prothrombotic Inflammatory Markers in Women With Metabolic Syndrome - Effect of Atorvastatin

    NCT01785615 · start 2004-11

    Registered record
    Registry ID
    NCT01785615
    Conditions
    Metabolic Syndrome
    Interventions
    Atorvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2004-11
    Completion
    2013-05
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Syndrome
    InterventionAtorvastatin; Placebo
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • A Study Of Atorvastatin For The Treatment Of High Cholesterol In Patients At High Risk Of Coronary Heart Disease (CHD)

    NCT00644709 · start 2003-09

    Registered record
    Registry ID
    NCT00644709
    Conditions
    Dyslipidemias
    Interventions
    Atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-09
    Completion
    2005-03
    Enrolment
    196

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyslipidemias
    InterventionAtorvastatin
    PhasePhase 4
    Registry statusCompleted

  • Full-dose Atorvastatin After Acute Coronary Syndrome (ACS) in Non-revascularisable Coronary Artery Disease

    NCT01187992 · start 2003-09

    Registered record
    Registry ID
    NCT01187992
    Conditions
    Acute Coronary Syndrome; Coronary Artery Disease
    Interventions
    Atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2003-09
    Completion
    2007-04
    Enrolment
    290

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome; Coronary Artery Disease
    InterventionAtorvastatin
    PhasePhase 3
    Registry statusTerminated

  • Direct Statin Comparison of LDL-C Values: an Evaluation of Rosuvastatin Therapy

    NCT00239330 · start 2003-06

    Registered record
    Registry ID
    NCT00239330
    Conditions
    Hypercholesteremia
    Interventions
    Rosuvastatin; Atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-06
    Completion
    2005-02
    Enrolment
    824

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesteremia
    InterventionRosuvastatin; Atorvastatin
    PhasePhase 3
    Registry statusCompleted