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AMR Drug RepurposingSmart Screeningresearch prototype

Biotin

FDA-approved product (injectable, injection).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Biotin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Chronic kidney disease
  • Iron deficiency anemia
  • Type 2 diabetes mellitus

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other plain vitamin preparations
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA31.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli19.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae40.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis14.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Biotin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Biotin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Exploring Wellbeing Outcomes in Adolescents Using Bifidobacterium Longum, 1714™: a Prospective Open-Label Real-World Study

    NCT07752342 · start 2026-09

    Registered record
    Registry ID
    NCT07752342
    Conditions
    Healthy Young Adults
    Interventions
    Bifidobacterium longum, 1714™
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-09
    Completion
    2027-04
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Young Adults
    InterventionBifidobacterium longum, 1714™
    PhaseNot applicable
    Registry statusNot yet recruiting

  • The Primary Purpose of This Study is to Determine if Biotin, Vitamin B7 is an Effective Way to Label Platelets in Survival and Recovery Studies.

    NCT07513532 · start 2026-04-06

    Registered record
    Registry ID
    NCT07513532
    Conditions
    Healthy Volunteers
    Interventions
    Biotin labeled platelets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2026-04-06
    Completion
    2026-07-10
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionBiotin labeled platelets
    PhasePhase 1
    Registry statusCompleted

  • Comparative Analysis of Biotinylated, Irradiated and 51-Chromium Radiolabeled Red Blood Cells for Analysis of Recovery and Survival After Autologous Transfusion

    NCT07446647 · start 2026-04-01

    Registered record
    Registry ID
    NCT07446647
    Conditions
    Healthy Volunteer Red Blood Cell Labeling Study; Not Disease Focused
    Interventions
    Biotinylated Red Blood Cells (BioRBC); Irradiated Biotinylated Red Blood Cells (Irradiated BioRBC); 51 Chromium Labeled Red Blood Cells (51Cr RBC); Technetium 99m Labeled Red Blood Cells (99mTc RBC)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Recruiting
    Start
    2026-04-01
    Completion
    2027-12-31
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteer Red Blood Cell Labeling Study; Not Disease Focused
    InterventionBiotinylated Red Blood Cells (BioRBC); Irradiated Biotinylated Red Blood Cells (Irradiated BioRBC); 51 Chromium Labeled Red Blood Cells (51Cr RBC); Technetium 99m Labeled Red Blood Cells (99mTc RBC)
    PhasePhase 1
    Registry statusRecruiting

  • Study Evaluating the Effect of Nutra Harmony "Biotin, Collagen and Keratin Beauty Complex" Dietary Supplement on Hair Thickness and Hair Strength in Adults With Self-Perceived Thinning Hair

    NCT07520019 · start 2026-01-15

    Registered record
    Registry ID
    NCT07520019
    Conditions
    Hair Thinning
    Interventions
    Complex with Biotin 5,000 mcg, Collagen, Keratin and Hyaluronic Acid.; Complex with Biotin 10,000 mcg, Collagen, Keratin and Hyaluronic Acid.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2026-01-15
    Completion
    2026-06-15
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHair Thinning
    InterventionComplex with Biotin 5,000 mcg, Collagen, Keratin and Hyaluronic Acid.; Complex with Biotin 10,000 mcg, Collagen, Keratin and Hyaluronic Acid.
    PhaseNot applicable
    Registry statusActive not recruiting

  • A Clinical Study to Evaluate the Efficacy of a Nutritional Supplement to Improve Carotenoid Content as Measured by a Non-invasive Hyperspectral Absorption Device

    NCT07380438 · start 2025-10-20

    Registered record
    Registry ID
    NCT07380438
    Conditions
    Nutrition Assessment
    Interventions
    LifePak Optimum nutritional supplement; Placebo supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-10-20
    Completion
    2026-01-08
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNutrition Assessment
    InterventionLifePak Optimum nutritional supplement; Placebo supplement
    PhaseNot applicable
    Registry statusCompleted

  • Biotin-Acridine Red Cell Exchange Kinetics

    NCT07155031 · start 2025-10-15

    Registered record
    Registry ID
    NCT07155031
    Conditions
    Sickle Cell Disease
    Interventions
    Pathogen reduced red blood cells
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2025-10-15
    Completion
    2026-12-15
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSickle Cell Disease
    InterventionPathogen reduced red blood cells
    PhasePhase 2
    Registry statusWithdrawn

  • Effects of a Dietary Supplement on Collagen Production and Evaluation of Its Regenerative and Anti-Ageing Propertiess

    NCT07521423 · start 2025-10-01

    Registered record
    Registry ID
    NCT07521423
    Conditions
    Healthy Ageing; Skin Ageing; Oxidative Stress
    Interventions
    Collagen-Supporting Nutraceutical Formulation; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-10-01
    Completion
    2026-03-01
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Ageing; Skin Ageing; Oxidative Stress
    InterventionCollagen-Supporting Nutraceutical Formulation; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Phase 1b/2a Trial of Allogeneic HSCT From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset Medically Refractory Crohn Disease

    NCT06986382 · start 2025-07

    Registered record
    Registry ID
    NCT06986382
    Conditions
    Crohn Disease
    Interventions
    CliniMACS® TCR α/β Reagent Kit and CliniMACS® CD19 System; Prednisone/Methylprenisolone; Palifermin; ATG; Clofarabine; Melphalan; Total Body Irradiation; Rituximab
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Not yet recruiting
    Start
    2025-07
    Completion
    2040-07
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCrohn Disease
    InterventionCliniMACS® TCR α/β Reagent Kit and CliniMACS® CD19 System; Prednisone/Methylprenisolone; Palifermin; ATG +4 more
    PhasePhase 1 / Phase 2
    Registry statusNot yet recruiting

  • Evaluation of the Effect of a Probiotic in Patients Undergoing Orthodontic Therapy

    NCT06752330 · start 2025-01-01

    Registered record
    Registry ID
    NCT06752330
    Conditions
    Orthodontics; Dental Hygiene; Gingivitis and Periodontal Diseases
    Interventions
    Use of probiotics during oral hygiene at home
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-01-01
    Completion
    2025-06-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOrthodontics; Dental Hygiene; Gingivitis and Periodontal Diseases
    InterventionUse of probiotics during oral hygiene at home
    PhaseNot applicable
    Registry statusCompleted

  • Aerobic Exercises on Persisted Post Burn Anemia

    NCT06849479 · start 2025-01-01

    Registered record
    Registry ID
    NCT06849479
    Conditions
    Burns
    Interventions
    Aerobic exercise and medical treatment; Medical treatment group
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2025-01-01
    Completion
    2025-03
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurns
    InterventionAerobic exercise and medical treatment; Medical treatment group
    PhaseNot applicable
    Registry statusActive not recruiting

  • Tissue Expression of Krüppel-Like Factors 4 and 7 in Bone Tumors

    NCT06935864 · start 2024-08-16

    Registered record
    Registry ID
    NCT06935864
    Conditions
    Osteosarcoma in Children; Ewing Sarcoma of Bone or Soft Tissue
    Interventions
    KLF factor (4 and 7)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2024-08-16
    Completion
    2026-02
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteosarcoma in Children; Ewing Sarcoma of Bone or Soft Tissue
    InterventionKLF factor (4 and 7)
    PhaseNot recorded
    Registry statusRecruiting

  • A Clinical Trial to Examine the Efficacy of a Supplement to Support Healthy Hair and Skin

    NCT06579742 · start 2024-06-07

    Registered record
    Registry ID
    NCT06579742
    Conditions
    Hair Thinning; Hair Loss
    Interventions
    Live Conscious Beyond Collagen; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-06-07
    Completion
    2024-12-31
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHair Thinning; Hair Loss
    InterventionLive Conscious Beyond Collagen; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Ozonated Oil Emulsion for Seborrhea in Women

    NCT07559617 · start 2024-04-06

    Registered record
    Registry ID
    NCT07559617
    Conditions
    Cosmetic Management of Oily Scalp
    Interventions
    Ozonated oil-based cosmetic emulsion; Matched vehicle control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-04-06
    Completion
    2024-05-18
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCosmetic Management of Oily Scalp
    InterventionOzonated oil-based cosmetic emulsion; Matched vehicle control
    PhaseNot applicable
    Registry statusCompleted

  • Optimization of Biotinylation Protocol for Studies of Red Blood Cell Survival and Function After Transfusion

    NCT06788080 · start 2024-03-07

    Registered record
    Registry ID
    NCT06788080
    Conditions
    Measuring Red Blood Cell Survival After Transfusion
    Interventions
    BioRBC
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2024-03-07
    Completion
    2024-11-04
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMeasuring Red Blood Cell Survival After Transfusion
    InterventionBioRBC
    PhaseEarly phase 1
    Registry statusCompleted

  • The Effect of 24-week Dietary Intake of Food Supplements on Hair

    NCT06174441 · start 2024-01-08

    Registered record
    Registry ID
    NCT06174441
    Conditions
    Hair Thinning; Hair Loss
    Interventions
    Investigational product 1 (CPMSM); Investigational product 2 (HC+); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-01-08
    Completion
    2024-10-25
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHair Thinning; Hair Loss
    InterventionInvestigational product 1 (CPMSM); Investigational product 2 (HC+); Placebo
    PhaseNot applicable
    Registry statusCompleted