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AMR Drug RepurposingSmart Screeningresearch prototype

Biotin

FDA-approved product (injectable, injection).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Biotin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Chronic kidney disease
  • Iron deficiency anemia
  • Type 2 diabetes mellitus

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other plain vitamin preparations
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA31.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli19.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae40.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis14.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Biotin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Biotin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Micronutrient Dose Response Study in Bangladesh

    NCT06081114 · start 2023-10-22

    Registered record
    Registry ID
    NCT06081114
    Conditions
    Micronutrient Status
    Interventions
    Micronutrient Supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2023-10-22
    Completion
    2027-12-31
    Enrolment
    643

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMicronutrient Status
    InterventionMicronutrient Supplement
    PhaseNot applicable
    Registry statusActive not recruiting

  • Use of Ritual Prenatal Multivitamins for Pregnancy

    NCT05673070 · start 2023-10-15

    Registered record
    Registry ID
    NCT05673070
    Conditions
    Pregnancy Related; Nutrition, Healthy
    Interventions
    Ritual Epre Multivitamin-mineral supplement; control MVI
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-10-15
    Completion
    2024-12-31
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Related; Nutrition, Healthy
    InterventionRitual Epre Multivitamin-mineral supplement; control MVI
    PhaseNot applicable
    Registry statusCompleted

  • A Clinical Study to Assess the Safety and Effectiveness of Plant-based Biotin and Plant Based Biotin with Silica in Healthy Human Subjects with Complaints of Hair Fall, Thin, Dry, & Brittle Hair, and Dry Skin

    NCT05972512 · start 2023-08-22

    Registered record
    Registry ID
    NCT05972512
    Conditions
    Hair Falling; Thin Hair; Dry Hair; Brittle Hair; Dry Skin
    Interventions
    Placebo; Botanical extract of standardized biotin; Botanical extract of standardised biotin with silica
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-08-22
    Completion
    2023-12-14
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHair Falling; Thin Hair; Dry Hair; Brittle Hair +1 more
    InterventionPlacebo; Botanical extract of standardized biotin; Botanical extract of standardised biotin with silica
    PhaseNot applicable
    Registry statusCompleted

  • Correcting GUT MicrobioTa by Combined Supplementation of FibERs and BIotiN to Improve Microbiome and Optimize Bariatric Surgery Outcomes

    NCT05832190 · start 2023-07-24

    Registered record
    Registry ID
    NCT05832190
    Conditions
    Severe Obesity; Metabolic Syndrome
    Interventions
    Standard of care; Biotin supplement; Fiber supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2023-07-24
    Completion
    2024-12-24
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSevere Obesity; Metabolic Syndrome
    InterventionStandard of care; Biotin supplement; Fiber supplement
    PhaseNot applicable
    Registry statusTerminated

  • A Clinical Study to Assess the Safety and Effectiveness of Plant Based Biotin in Healthy Human Subjects With Thin, Dry, and Brittle Hair

    NCT05800496 · start 2022-10-31

    Registered record
    Registry ID
    NCT05800496
    Conditions
    Hair Thinning; Hair Brittle; Dry Hair
    Interventions
    SesZen-Bio™; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-10-31
    Completion
    2023-01-10
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHair Thinning; Hair Brittle; Dry Hair
    InterventionSesZen-Bio™; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Can Biotin Supplementation be Used to Mask hCG Abuse?

    NCT05450900 · start 2022-10-27

    Registered record
    Registry ID
    NCT05450900
    Conditions
    Healthy
    Interventions
    Choriogonadotropin Alpha; biotin; Microcellulose filler
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2022-10-27
    Completion
    2023-02-02
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionChoriogonadotropin Alpha; biotin; Microcellulose filler
    PhaseEarly phase 1
    Registry statusCompleted

  • The Possible Efficacy and Safety of L-carnitine and Biotin as Adjunctive Therapies in Children With Moderate Persistent Asthma

    NCT05632549 · start 2022-08-08

    Registered record
    Registry ID
    NCT05632549
    Conditions
    Moderate Persistent Asthma
    Interventions
    Placebo; L-Carnitine 500Mg Oral Tablet; Biotin Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2022-08-08
    Completion
    2024-08-08
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionModerate Persistent Asthma
    InterventionPlacebo; L-Carnitine 500Mg Oral Tablet; Biotin Capsules
    PhasePhase 3
    Registry statusUnknown

  • An Exploratory Investigation of a Supplement to Promote Cognitive Health Benefits

    NCT05523115 · start 2022-06-15

    Registered record
    Registry ID
    NCT05523115
    Conditions
    Anxiety; Stress; Memory Deficits; Cortisol Overproduction
    Interventions
    Heights Smart Supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-06-15
    Completion
    2022-10-01
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety; Stress; Memory Deficits; Cortisol Overproduction
    InterventionHeights Smart Supplement
    PhaseNot applicable
    Registry statusCompleted

  • Effects of an Acute Dose of Caffeine on the Performance of CrossFit Athletes

    NCT06891469 · start 2022-01-22

    Registered record
    Registry ID
    NCT06891469
    Conditions
    Healthy, Young Adults; Athletic Performance
    Interventions
    Caffeine administration according to body mass (moderate intake- 7 mg/kg); Placebo (Biotin Capsules)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-01-22
    Completion
    2022-05-29
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy, Young Adults; Athletic Performance
    InterventionCaffeine administration according to body mass (moderate intake- 7 mg/kg); Placebo (Biotin Capsules)
    PhaseNot applicable
    Registry statusCompleted

  • Red Cell Half Life Determination in Patients With and Without Sickle Cell Disease

    NCT04476277 · start 2021-04-19

    Registered record
    Registry ID
    NCT04476277
    Conditions
    Sickle Cell Disease; Sickle Cell Anemia
    Interventions
    Biotin label
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2021-04-19
    Completion
    2023-02-14
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSickle Cell Disease; Sickle Cell Anemia
    InterventionBiotin label
    PhaseEarly phase 1
    Registry statusCompleted

  • Intervention for Multivitamin Adherence on Bariatric Patients

    NCT04612088 · start 2020-09-14

    Registered record
    Registry ID
    NCT04612088
    Conditions
    Adherence, Medication
    Interventions
    Cognitive Dissonance
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-09-14
    Completion
    2021-05-24
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdherence, Medication
    InterventionCognitive Dissonance
    PhaseNot applicable
    Registry statusUnknown

  • Study of the Effect of 12-week Dietary Supplementation With a Multicomponent Nutritional Supplement on Nails and Skin

    NCT05100680 · start 2019-11-25

    Registered record
    Registry ID
    NCT05100680
    Conditions
    Nail Damage
    Interventions
    Multicomp; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-11-25
    Completion
    2020-09-01
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNail Damage
    InterventionMulticomp; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • TQT2 Study to Evaluate the Effect of MD1003 on Cardiac Repolarization in Healthy Adult Subjects

    NCT04168723 · start 2019-11-11

    Registered record
    Registry ID
    NCT04168723
    Conditions
    Healthy Volunteers
    Interventions
    MD1003; Moxifloxacin 400mg; Placebo for MD1003; Placebo for moxifloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2019-11-11
    Completion
    2020-03-05
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionMD1003; Moxifloxacin 400mg; Placebo for MD1003; Placebo for moxifloxacin
    PhasePhase 1
    Registry statusUnknown

  • Transfusion of Biotin-Labeled Red Blood Cells

    NCT03364686 · start 2019-09-16

    Registered record
    Registry ID
    NCT03364686
    Conditions
    Healthy Volunteers
    Interventions
    Biotin-Labeled Red Blood Cells
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2019-09-16
    Completion
    2021-06-29
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionBiotin-Labeled Red Blood Cells
    PhasePhase 2
    Registry statusTerminated

  • Dietary Supplementation in Heart Failure

    NCT03980574 · start 2019-04-01

    Registered record
    Registry ID
    NCT03980574
    Conditions
    Heart Failure
    Interventions
    R Drink
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-04-01
    Completion
    2020-06-29
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure
    InterventionR Drink
    PhaseNot applicable
    Registry statusCompleted