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AMR Drug RepurposingSmart Screeningresearch prototype

Triamcinolone Acetonide

FDA-approved product (ointment, topical), marketed as Allernaze, Aristocort, Aristocort A and 24 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Triamcinolone Acetonide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Allergic rhinitis
  • Anemia
  • Asthma
  • Bursitis
  • Dermatitis
  • Epicondylitis
  • Frozen shoulder
  • Fungal infectious disease
  • Gout
  • Injury
  • Lateral epicondylitis
  • Multiple sclerosis
  • Nasal congestion
  • Osteoarthritis
  • Pain
  • Pulmonary tuberculosis
  • and 5 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae24.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis30.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Triamcinolone Acetonide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triamcinolone Acetonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Role of Methane in Glycemic Control

    NCT01638429 · start 2012-04

    Registered record
    Registry ID
    NCT01638429
    Conditions
    Diabetes; Obesity
    Interventions
    Neomycin; Rifaximin
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2012-04
    Completion
    2014-04
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes; Obesity
    InterventionNeomycin; Rifaximin
    PhaseEarly phase 1
    Registry statusCompleted

  • Cellular Immunity in Adult Hepatitis B-vaccinated Serologic Non-responders

    NCT01451801 · start 2011-10

    Registered record
    Registry ID
    NCT01451801
    Conditions
    Hepatitis B
    Interventions
    Twinrix
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-10
    Completion
    2013-07
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis B
    InterventionTwinrix
    PhasePhase 4
    Registry statusUnknown

  • Study of Ear Comfort Ear Drops to Treat AOE Cases Compared to DexOtic & Otidin(R)

    NCT01584271 · start 2011-07

    Registered record
    Registry ID
    NCT01584271
    Conditions
    Acute Otitis Externa
    Interventions
    Natural Ear Comfort(TM), a botanical ear drops product
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2011-07
    Completion
    2013-12
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Otitis Externa
    InterventionNatural Ear Comfort(TM), a botanical ear drops product
    PhasePhase 2
    Registry statusUnknown

  • Efficacy of the Combination Bismuth + Neomycin + Procaine in the Treatment of Recurrent Aphthous Ulceration

    NCT00857688 · start 2011-05

    Registered record
    Registry ID
    NCT00857688
    Conditions
    Aphtous Ulcers
    Interventions
    Bismu-Jet; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-05
    Completion
    2011-11
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAphtous Ulcers
    InterventionBismu-Jet; Placebo
    PhasePhase 3
    Registry statusCompleted

  • A Fixed Triple Combination Cream for Solar Lentigines Associated to Cryotherapy

    NCT01778179 · start 2011-04

    Registered record
    Registry ID
    NCT01778179
    Conditions
    Solar Lentigines
    Interventions
    Tri-luma; Cryotherapy (CRY-AC3® device)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-04
    Completion
    2012-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSolar Lentigines
    InterventionTri-luma; Cryotherapy (CRY-AC3® device)
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy Maxinom® And Maxitrol® in Reducing The Signs And Symptoms Of Acute Bacterial Conjunctivitis

    NCT01227863 · start 2011-02

    Registered record
    Registry ID
    NCT01227863
    Conditions
    Bacterial Conjunctivitis; Acute
    Interventions
    MAXINOM®; Maxitrol®
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2011-02
    Completion
    Not recorded
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Conjunctivitis; Acute
    InterventionMAXINOM®; Maxitrol®
    PhasePhase 3
    Registry statusUnknown

  • An Effectiveness Study of Paromomycin IM Injection (PMIM) for the Treatment of Visceral Leishmaniasis (VL) in Bangladesh

    NCT01328457 · start 2011-01

    Registered record
    Registry ID
    NCT01328457
    Conditions
    Visceral Leishmaniasis
    Interventions
    Paromomycin sulfate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-01
    Completion
    2012-06
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVisceral Leishmaniasis
    InterventionParomomycin sulfate
    PhaseNot applicable
    Registry statusCompleted

  • Neomycin and Rifaximin Plus Neomycin in Treating Methane Positive Constipation Predominant Irritable Bowel Syndrome

    NCT00945334 · start 2009-08

    Registered record
    Registry ID
    NCT00945334
    Conditions
    Constipation-predominant Irritable Bowel Syndrome
    Interventions
    Neomycin; Placebo; Rifaximin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-08
    Completion
    2013-06
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionConstipation-predominant Irritable Bowel Syndrome
    InterventionNeomycin; Placebo; Rifaximin
    PhaseNot applicable
    Registry statusCompleted

  • Enterobacteriaceae Producing Extended-spectrum β-lactamases (ESBL) Decolonization Study

    NCT00826670 · start 2009-06

    Registered record
    Registry ID
    NCT00826670
    Conditions
    Enterobacteriaceae Infections
    Interventions
    Decolonization; Placebo (Decolonization)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-06
    Completion
    2012-08
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnterobacteriaceae Infections
    InterventionDecolonization; Placebo (Decolonization)
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of 5% Chitosan Nanoparticle Paste in the Treatment of Recurrent Aphthous Stomatitis

    NCT07702474 · start 2009-04-21

    Registered record
    Registry ID
    NCT07702474
    Conditions
    Recurrent Aphthous Stomatitis; Oral Ulcers
    Interventions
    Triamcinolone Acetonide 0.1% Oral Paste; 5 wt.% Chitosan Nanoparticle Paste
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-04-21
    Completion
    2009-12-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Aphthous Stomatitis; Oral Ulcers
    InterventionTriamcinolone Acetonide 0.1% Oral Paste; 5 wt.% Chitosan Nanoparticle Paste
    PhasePhase 2
    Registry statusCompleted

  • Antibiotic Prophylaxis in Children With Pyelonephritis

    NCT00752375 · start 2009-02

    Registered record
    Registry ID
    NCT00752375
    Conditions
    Pyelonephritis
    Interventions
    Trimethoprim Sulfamethoxazole; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2009-02
    Completion
    2014-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPyelonephritis
    InterventionTrimethoprim Sulfamethoxazole; placebo
    PhasePhase 3
    Registry statusWithdrawn

  • Comparison Between Erythromycin and Neomycin Treatment of Hepatic Encephalopathy

    NCT01097811 · start 2008-06

    Registered record
    Registry ID
    NCT01097811
    Conditions
    Hepatic Encephalopathy; Hypertension, Portal; Liver Cirrhosis
    Interventions
    Erythromycin; Neomycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2008-06
    Completion
    2010-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatic Encephalopathy; Hypertension, Portal; Liver Cirrhosis
    InterventionErythromycin; Neomycin
    PhaseNot applicable
    Registry statusUnknown

  • Triamcinolone Versus Topical Treatment in Post Operative Phacoemulsification

    NCT00789971 · start 2007-03

    Registered record
    Registry ID
    NCT00789971
    Conditions
    Ocular Inflammation
    Interventions
    triamcinolone acetonide; Maxitriol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-03
    Completion
    2008-04
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOcular Inflammation
    Interventiontriamcinolone acetonide; Maxitriol
    PhaseNot applicable
    Registry statusCompleted

  • Antibiotics for the Treatment of Ulcerative Colitis

    NCT00355602 · start 2006-07

    Registered record
    Registry ID
    NCT00355602
    Conditions
    Colitis, Ulcerative
    Interventions
    Cefuroxime; Ciprofloxacin; Clarithromycin; Cotrimoxazole; Coamoxiclav; metronidazole; neomycin; rifaximin; Vancomycin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-07
    Completion
    2008-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColitis, Ulcerative
    InterventionCefuroxime; Ciprofloxacin; Clarithromycin; Cotrimoxazole +6 more
    PhaseNot applicable
    Registry statusCompleted

  • Safety and Immunogenicity of Various Formulations of Live Attenuated Tetravalent Dengue Vaccine in Healthy US Adults

    NCT00350337 · start 2006-04-05

    Registered record
    Registry ID
    NCT00350337
    Conditions
    Dengue
    Interventions
    Pre-transfection F17; Post-transfection F17; Post-transfection F19; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-04-05
    Completion
    2008-03-13
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDengue
    InterventionPre-transfection F17; Post-transfection F17; Post-transfection F19; Placebo
    PhasePhase 2
    Registry statusCompleted