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AMR Drug RepurposingSmart Screeningresearch prototype

Triamcinolone Acetonide

FDA-approved product (ointment, topical), marketed as Allernaze, Aristocort, Aristocort A and 24 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Triamcinolone Acetonide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Allergic rhinitis
  • Anemia
  • Asthma
  • Bursitis
  • Dermatitis
  • Epicondylitis
  • Frozen shoulder
  • Fungal infectious disease
  • Gout
  • Injury
  • Lateral epicondylitis
  • Multiple sclerosis
  • Nasal congestion
  • Osteoarthritis
  • Pain
  • Pulmonary tuberculosis
  • and 5 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae24.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis30.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Triamcinolone Acetonide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triamcinolone Acetonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

    NCT03476317 · start 2018-07-12

    Registered record
    Registry ID
    NCT03476317
    Conditions
    Crohn Disease
    Interventions
    Vancomycin; Neomycin; Ciprofloxacin; Polyethylene Glycol 3350; Fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2018-07-12
    Completion
    2020-12-31
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCrohn Disease
    InterventionVancomycin; Neomycin; Ciprofloxacin; Polyethylene Glycol 3350 +1 more
    PhasePhase 2
    Registry statusCompleted

  • Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing

    NCT02682485 · start 2017-03-03

    Registered record
    Registry ID
    NCT02682485
    Conditions
    Anastomotic Leak; Rectal Cancer
    Interventions
    Cipro, metronidazole, neomycin combo; Serial Endoscopic Surveillance; Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2017-03-03
    Completion
    2017-03-03
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnastomotic Leak; Rectal Cancer
    InterventionCipro, metronidazole, neomycin combo; Serial Endoscopic Surveillance; Saline
    PhasePhase 2
    Registry statusWithdrawn

  • Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma

    NCT02792036 · start 2016-11-01

    Registered record
    Registry ID
    NCT02792036
    Conditions
    Retinoblastoma
    Interventions
    Carboplatin; Maxitrol®; Focal Therapy; Plaque Radiotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-11-01
    Completion
    2019-10-04
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRetinoblastoma
    InterventionCarboplatin; Maxitrol®; Focal Therapy; Plaque Radiotherapy
    PhasePhase 1
    Registry statusCompleted

  • Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery

    NCT03042091 · start 2016-09

    Registered record
    Registry ID
    NCT03042091
    Conditions
    Colorectal Neoplasms; Diverticulitis; Inflammatory Bowel Diseases; Surgical Site Infection
    Interventions
    Polyethylene Glycol; Neomycin; Metronidazole Hydrochloride; Therapeutic Conventional Surgery
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2016-09
    Completion
    2021-10
    Enrolment
    224

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Neoplasms; Diverticulitis; Inflammatory Bowel Diseases; Surgical Site Infection
    InterventionPolyethylene Glycol; Neomycin; Metronidazole Hydrochloride; Therapeutic Conventional Surgery
    PhaseEarly phase 1
    Registry statusUnknown

  • Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease

    NCT02765256 · start 2016-08

    Registered record
    Registry ID
    NCT02765256
    Conditions
    Crohn's Disease
    Interventions
    Fluconazole; Vancomycin; Neomycin; Ciprofloxacin; Polyethylene Glycol 3350; Promethazine; Fluconazole placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-08
    Completion
    2018-12
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCrohn's Disease
    InterventionFluconazole; Vancomycin; Neomycin; Ciprofloxacin +3 more
    PhasePhase 2
    Registry statusCompleted

  • Interventional Bioremediation of Microbiota in Metabolic Syndrome

    NCT02730962 · start 2016-06

    Registered record
    Registry ID
    NCT02730962
    Conditions
    Pre-Diabetes
    Interventions
    Vancomycin; Placebo; Neomycin; Clindamycin; Fecal Microbiota Transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2016-06
    Completion
    2018-01
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPre-Diabetes
    InterventionVancomycin; Placebo; Neomycin; Clindamycin +1 more
    PhasePhase 2
    Registry statusTerminated

  • MOBILE Trial. Mechanical and Oral Antibiotic Bowel Preparation Versus no Bowel preparatIon for eLEctive Colectomy - a Multicenter, Prospective, Randomized, Controlled Trial.

    NCT02652637 · start 2016-03

    Registered record
    Registry ID
    NCT02652637
    Conditions
    Colorectal Surgery
    Interventions
    neomycin, metronidazole, polyethylene glycol (PEG)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-03
    Completion
    2023-08
    Enrolment
    417

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Surgery
    Interventionneomycin, metronidazole, polyethylene glycol (PEG)
    PhasePhase 4
    Registry statusUnknown

  • Eradication of Antibiotic-resistant Bacteria Through Antibiotics and Fecal Bacteriotherapy

    NCT02472600 · start 2016-02

    Registered record
    Registry ID
    NCT02472600
    Conditions
    Intestinal Colonization With Multidrug-resistant Bacteria
    Interventions
    Colistin; Neomycin; Fecal microbiota transplantation (FMT); Omeprazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2016-02
    Completion
    2018-03
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntestinal Colonization With Multidrug-resistant Bacteria
    InterventionColistin; Neomycin; Fecal microbiota transplantation (FMT); Omeprazole
    PhasePhase 2
    Registry statusUnknown

  • Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics

    NCT02154061 · start 2015-04

    Registered record
    Registry ID
    NCT02154061
    Conditions
    Influenza
    Interventions
    IIV Flu Vaccine; Metronidazole; Neomycin; Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-04
    Completion
    2017-05-26
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfluenza
    InterventionIIV Flu Vaccine; Metronidazole; Neomycin; Vancomycin
    PhaseNot applicable
    Registry statusCompleted

  • Trial to Test if Antibiotic Ointments & Cream Will Sting After Application on a Minor Wound After Tape Stripping Injury

    NCT02320695 · start 2015-03

    Registered record
    Registry ID
    NCT02320695
    Conditions
    Sting
    Interventions
    Saline; Isopropyl Alcohol; Pain Relieving Cream; Antibiotic/Pain Relieving Ointment; Original Ointment; Pain Relief Ointment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-03
    Completion
    2015-03
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSting
    InterventionSaline; Isopropyl Alcohol; Pain Relieving Cream; Antibiotic/Pain Relieving Ointment +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Neo-Synalar Modified 48 Hour Patch Test

    NCT02168478 · start 2014-06

    Registered record
    Registry ID
    NCT02168478
    Conditions
    Allergy
    Interventions
    Neo-Synalar Cream; Sodium Lauryl Sulfate Aqueous Solution (0.40%); Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-06
    Completion
    2014-06
    Enrolment
    206

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergy
    InterventionNeo-Synalar Cream; Sodium Lauryl Sulfate Aqueous Solution (0.40%); Saline
    PhasePhase 4
    Registry statusCompleted

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated

  • Simplified Selective Digestive Tract Decontamination for the Prevention of Intensive Care Unit Acquired Infections

    NCT01798537 · start 2013-06

    Registered record
    Registry ID
    NCT01798537
    Conditions
    Bacteremia Associated With Intravascular Line; Ventilator Associated Pneumonia; Bacteremia
    Interventions
    Neomycin Colistin Nystatin Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2013-06
    Completion
    2015-07
    Enrolment
    2,400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia Associated With Intravascular Line; Ventilator Associated Pneumonia; Bacteremia
    InterventionNeomycin Colistin Nystatin Vancomycin
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Comparison Between Bandage Contact Lens and Pressure Patching for The Erosion Area and Pain Scale in Corneal Erosion Patients

    NCT01809483 · start 2012-09

    Registered record
    Registry ID
    NCT01809483
    Conditions
    Erosion; Cornea, Traumatic
    Interventions
    Bandage contact lens; Pressure patching
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-09
    Completion
    2013-02
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErosion; Cornea, Traumatic
    InterventionBandage contact lens; Pressure patching
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Intestinal Decontamination in Patients Colonized by Carbapenem-resistant Klebsiella Pneumoniae and Colistin

    NCT02604849 · start 2012-07

    Registered record
    Registry ID
    NCT02604849
    Conditions
    Patients Colonized by Klebsiella Pneumoniae.
    Interventions
    Neomycin; Streptomycin; Gentamicins
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-07
    Completion
    2015-11
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients Colonized by Klebsiella Pneumoniae.
    InterventionNeomycin; Streptomycin; Gentamicins
    PhaseNot recorded
    Registry statusCompleted