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AMR Drug RepurposingSmart Screeningresearch prototype

Triamcinolone Acetonide

FDA-approved product (ointment, topical), marketed as Allernaze, Aristocort, Aristocort A and 24 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Triamcinolone Acetonide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Allergic rhinitis
  • Anemia
  • Asthma
  • Bursitis
  • Dermatitis
  • Epicondylitis
  • Frozen shoulder
  • Fungal infectious disease
  • Gout
  • Injury
  • Lateral epicondylitis
  • Multiple sclerosis
  • Nasal congestion
  • Osteoarthritis
  • Pain
  • Pulmonary tuberculosis
  • and 5 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae24.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis30.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Triamcinolone Acetonide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triamcinolone Acetonide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Gut Decolonisation With Neomycin/Metronidazole or Rifaximin Before Colon Surgery

    NCT07180615 · start 2026-06-01

    Registered record
    Registry ID
    NCT07180615
    Conditions
    Surgical Site Infection; Colon Surgery; Surgical Site Infections
    Interventions
    Rifaximin (Xifaxan); Metronidazole; Neomycin Sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-06-01
    Completion
    2029-06-30
    Enrolment
    458

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection; Colon Surgery; Surgical Site Infections
    InterventionRifaximin (Xifaxan); Metronidazole; Neomycin Sulfate
    PhasePhase 4
    Registry statusNot yet recruiting

  • Sebum Metabolomics and Lipidomics for Clinical Applications

    NCT07549828 · start 2026-04-01

    Registered record
    Registry ID
    NCT07549828
    Conditions
    Acne; Atopic Dermatitis; Seborrheic Dermatitis; Psoriasis; Healthy Subjects (HS)
    Interventions
    Sebutape sampling; Bacitracin/Polymyxin B/Neomycin ointment (Yentuogin ointment)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-04-01
    Completion
    2029-03-31
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne; Atopic Dermatitis; Seborrheic Dermatitis; Psoriasis +1 more
    InterventionSebutape sampling; Bacitracin/Polymyxin B/Neomycin ointment (Yentuogin ointment)
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Do Topical Antibiotics Improve Skin Graft Results?

    NCT07286851 · start 2024-12-01

    Registered record
    Registry ID
    NCT07286851
    Conditions
    Skin Transplantation; Wounds and Injuries; Antibiotic Prophylaxis Surgery
    Interventions
    Neomycin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2024-12-01
    Completion
    2025-08-31
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Transplantation; Wounds and Injuries; Antibiotic Prophylaxis Surgery
    InterventionNeomycin
    PhaseNot recorded
    Registry statusCompleted

  • Topical Phenytoin-Loaded Hydrogel Dressing for Postoperative Wound Management After Oral Squamous Cell Carcinoma Resection

    NCT07801157 · start 2024-07-01

    Registered record
    Registry ID
    NCT07801157
    Conditions
    Postoperative Wound Healing After Oral Cancer Surgery
    Interventions
    Topical Phenytoin-Loaded Hydrogel Dressing; Conventional Postoperative Wound Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-07-01
    Completion
    2025-12-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Wound Healing After Oral Cancer Surgery
    InterventionTopical Phenytoin-Loaded Hydrogel Dressing; Conventional Postoperative Wound Care
    PhaseNot applicable
    Registry statusCompleted

  • Antibiotics and Vaccine Immune Responses Study

    NCT06148025 · start 2023-11-23

    Registered record
    Registry ID
    NCT06148025
    Conditions
    Vaccine Response Impaired
    Interventions
    BCG vaccine; Yellow Fever vaccine; Vancomycin Oral Capsule; Neomycin Oral Product; Metoclopramide (Maxolon); Loperamide HCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2023-11-23
    Completion
    2028-10-01
    Enrolment
    348

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaccine Response Impaired
    InterventionBCG vaccine; Yellow Fever vaccine; Vancomycin Oral Capsule; Neomycin Oral Product +2 more
    PhasePhase 4
    Registry statusRecruiting

  • Evaluating the Safety and Efficacy of Oral Encapsulated Microbiota Transplantation Therapy in Peanut Allergic Patients

    NCT05695261 · start 2023-06-08

    Registered record
    Registry ID
    NCT05695261
    Conditions
    Allergy, Peanut; Peanut Allergy; Peanut Hypersensitivity; Peanut-Induced Anaphylaxis; Food Allergy; Food Allergy Peanut
    Interventions
    Microbial Transplantation Therapy; Antibiotic; Placebo (in place of MTT); Placebo (in place of antibiotics); Oral Immunotherapy (OIT)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2023-06-08
    Completion
    2027-03-01
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergy, Peanut; Peanut Allergy; Peanut Hypersensitivity; Peanut-Induced Anaphylaxis +2 more
    InterventionMicrobial Transplantation Therapy; Antibiotic; Placebo (in place of MTT); Placebo (in place of antibiotics) +1 more
    PhasePhase 2
    Registry statusRecruiting

  • Precision Alemtuzumab Dosing for Allogeneic Hematopoietic Cell Transplantation

    NCT05501756 · start 2023-01-11

    Registered record
    Registry ID
    NCT05501756
    Conditions
    Allogeneic Hematopoietic Cell Transplantation
    Interventions
    Alemtuzumab
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2023-01-11
    Completion
    2028-08-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllogeneic Hematopoietic Cell Transplantation
    InterventionAlemtuzumab
    PhasePhase 2
    Registry statusRecruiting

  • Decolonization of Carbapenem-resistant Enterobacterales (CRE) in Patients With Faecal Carriage of CRE With Neomycin

    NCT05593601 · start 2022-11-24

    Registered record
    Registry ID
    NCT05593601
    Conditions
    Colonization, Asymptomatic
    Interventions
    Neomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2022-11-24
    Completion
    2024-03-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColonization, Asymptomatic
    InterventionNeomycin
    PhasePhase 4
    Registry statusUnknown

  • Dropless Pars Plana Vitrectomy Study

    NCT05331664 · start 2022-07-25

    Registered record
    Registry ID
    NCT05331664
    Conditions
    Rhegmatogenous Retinal Detachment
    Interventions
    Pars plana vitrectomy; Triamcinolone Acetonide 40mg/mL; Moxifloxacin 0.5% or Polymyxin/Trimethoprim if patient is allergic to moxifloxacin; Prednisolone 1%; Atropine 1%
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-07-25
    Completion
    2026-08-30
    Enrolment
    168

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhegmatogenous Retinal Detachment
    InterventionPars plana vitrectomy; Triamcinolone Acetonide 40mg/mL; Moxifloxacin 0.5% or Polymyxin/Trimethoprim if patient is allergic to moxifloxacin; Prednisolone 1% +1 more
    PhasePhase 4
    Registry statusCompleted

  • Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

    NCT05157113 · start 2022-05-31

    Registered record
    Registry ID
    NCT05157113
    Conditions
    Cataract; Surgery; Compliance, Patient; Compliance, Medication; Satisfaction, Patient
    Interventions
    Dropless Regimen; Standard Regimen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2022-05-31
    Completion
    2026-06-01
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCataract; Surgery; Compliance, Patient; Compliance, Medication +1 more
    InterventionDropless Regimen; Standard Regimen
    PhasePhase 4
    Registry statusRecruiting

  • A First-in-human (FIH) Combination Treatment Study With a Single Dose Level of BMC128

    NCT05354102 · start 2022-05-01

    Registered record
    Registry ID
    NCT05354102
    Conditions
    Non-small Cell Lung Cancer; Melanoma; Renal Cell Carcinoma
    Interventions
    BMC128; Nivolumab
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2022-05-01
    Completion
    2025-11
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-small Cell Lung Cancer; Melanoma; Renal Cell Carcinoma
    InterventionBMC128; Nivolumab
    PhasePhase 1
    Registry statusUnknown

  • Phage Therapy for the Prevention and Treatment of Wound Infections in Burned Patients

    NCT04323475 · start 2022-01

    Registered record
    Registry ID
    NCT04323475
    Conditions
    Wound Infection
    Interventions
    Bacteriophage cocktail spray; Xeroform
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2022-01
    Completion
    2023-08
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Infection
    InterventionBacteriophage cocktail spray; Xeroform
    PhasePhase 1
    Registry statusUnknown

  • Safety of Sabin Inactivated Poliovirus Vaccine in Adults, Children and Infants and Lot Consistency Immunogenicity, and Safety of the msIPV in 2 Months Old Infants

    NCT05386810 · start 2020-11-05

    Registered record
    Registry ID
    NCT05386810
    Conditions
    Poliomyelitis
    Interventions
    Experimental vaccine; IPV control vaccine; single-person sIPV control vaccine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2020-11-05
    Completion
    2023-07-20
    Enrolment
    1,572

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPoliomyelitis
    InterventionExperimental vaccine; IPV control vaccine; single-person sIPV control vaccine
    PhasePhase 3
    Registry statusCompleted

  • Analysis of MicroBial Metabolites After Eating Refined Food

    NCT04308473 · start 2020-09-01

    Registered record
    Registry ID
    NCT04308473
    Conditions
    Dietary Habits
    Interventions
    Ultra-processed Food Meal; Whole Food Meal
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-09-01
    Completion
    2026-04-30
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDietary Habits
    InterventionUltra-processed Food Meal; Whole Food Meal
    PhaseNot applicable
    Registry statusCompleted

  • Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery

    NCT04281667 · start 2020-03-18

    Registered record
    Registry ID
    NCT04281667
    Conditions
    Rectal Adenocarcinoma; Rectum Neoplasm; Rectum Carcinoma; Colorectal Cancer; Colorectal Neoplasms; Colorectal Carcinoma; Surgical Site Infection; Surgery--Complications
    Interventions
    Oral Antibiotics; Placebo; Mechanical Bowel Preparation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2020-03-18
    Completion
    2027-10-10
    Enrolment
    604

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRectal Adenocarcinoma; Rectum Neoplasm; Rectum Carcinoma; Colorectal Cancer +4 more
    InterventionOral Antibiotics; Placebo; Mechanical Bowel Preparation
    PhasePhase 4
    Registry statusActive not recruiting