Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Rocuronium Bromide

FDA-approved product (injectable, injection), marketed as Rocuronium Bromide, Zemuron.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Rocuronium Bromide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Rocuronium Bromide. Its therapeutic class is shown instead.

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA59.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis37.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Rocuronium Bromide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Rocuronium Bromide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Remimazolam for Postoperative Sleep in Elderly Patients

    NCT07740343 · start 2026-08-01

    Registered record
    Registry ID
    NCT07740343
    Conditions
    Postoperative Sleep
    Interventions
    Remimazolam; propofol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-08-01
    Completion
    2027-02-28
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Sleep
    InterventionRemimazolam; propofol
    PhaseNot applicable
    Registry statusRecruiting

  • Deep Neuromuscular Blockade and a Low-Residue Diet for the Surgical Field in vNOTES Hysterectomy

    NCT07730970 · start 2026-07-01

    Registered record
    Registry ID
    NCT07730970
    Conditions
    Leiomyoma, Uterine; Benign Gynecological Disease; Abnormal Uterine Bleeding (AUB); Uterine Prolapse; Adenomyosis of Uterus
    Interventions
    Deep Neuromuscular Blockade (NMB); Standard (moderate) neuromuscular blockade; Preoperative low-residue diet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-07-01
    Completion
    2027-09-01
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeiomyoma, Uterine; Benign Gynecological Disease; Abnormal Uterine Bleeding (AUB); Uterine Prolapse +1 more
    InterventionDeep Neuromuscular Blockade (NMB); Standard (moderate) neuromuscular blockade; Preoperative low-residue diet
    PhaseNot applicable
    Registry statusRecruiting

  • Deep Versus Moderate Neuromuscular Blocking

    NCT07485517 · start 2026-06-01

    Registered record
    Registry ID
    NCT07485517
    Conditions
    Change in Serum Levels of the Estimated Inflammatory Cytokines; Total Dose of IO Fentanyl; PO Morphine; Surgeons' Rating; Pain Scores
    Interventions
    Moderate Neuromuscular Blockade; Deep neuromuscular block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-06-01
    Completion
    2026-12-30
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChange in Serum Levels of the Estimated Inflammatory Cytokines; Total Dose of IO Fentanyl; PO Morphine; Surgeons' Rating +1 more
    InterventionModerate Neuromuscular Blockade; Deep neuromuscular block
    PhaseNot applicable
    Registry statusRecruiting

  • A Dose-response Study to Determine the Right Dosage of Sugammadex as a Reversal Agent of Rocuronium in Infants Between 1 and 24 Months Old

    NCT07477132 · start 2026-03-30

    Registered record
    Registry ID
    NCT07477132
    Conditions
    Curarization, Postoperative Residual
    Interventions
    Sugammadex
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-03-30
    Completion
    2027-10-01
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCurarization, Postoperative Residual
    InterventionSugammadex
    PhasePhase 4
    Registry statusNot yet recruiting

  • Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP

    NCT07607990 · start 2026-01-01

    Registered record
    Registry ID
    NCT07607990
    Conditions
    Prostate Cancer (Post Prostatectomy); Perioperative Anesthetic; Catheter-related Bladder Discomfort (CRBD)
    Interventions
    Indomethacin suppository
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-01-01
    Completion
    2026-12-31
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer (Post Prostatectomy); Perioperative Anesthetic; Catheter-related Bladder Discomfort (CRBD)
    InterventionIndomethacin suppository
    PhaseNot applicable
    Registry statusRecruiting

  • Application of Low-dose Muscle Relaxants in Bronchoscopic Interventional Procedures

    NCT07035301 · start 2025-03-17

    Registered record
    Registry ID
    NCT07035301
    Conditions
    Disease of Respiratory System
    Interventions
    Normal Saline (Placebo); Lidocaine Intravenous Infusion; Remimazolam Tosilate; Remifentanil; Rocuronium (0.15mg/kg/body mass)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-03-17
    Completion
    2025-07-31
    Enrolment
    153

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDisease of Respiratory System
    InterventionNormal Saline (Placebo); Lidocaine Intravenous Infusion; Remimazolam Tosilate; Remifentanil +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Regional Anesthesia Techniques in Breast Surgery

    NCT06779656 · start 2025-02-01

    Registered record
    Registry ID
    NCT06779656
    Conditions
    Augmentation; Fibroadenoma; Mastectomy
    Interventions
    General Anesthesia (GA); Paravertebral Block (PVB); Rhomboid Intercostal and Subserratus Plane Block (RISS); Pectoral Nerves Block II (PECS II); Intercostal Nerve Block (INB); Serratus Anterior Plane Block (SAPB); Epidural Block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2025-02-01
    Completion
    2025-05-10
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAugmentation; Fibroadenoma; Mastectomy
    InterventionGeneral Anesthesia (GA); Paravertebral Block (PVB); Rhomboid Intercostal and Subserratus Plane Block (RISS); Pectoral Nerves Block II (PECS II) +3 more
    PhaseNot applicable
    Registry statusNot yet recruiting

  • LAPOFAR Trial: Opioid-Free vs. Remifentanil Anesthesia in Laparoscopic Cholecystectomy

    NCT07307625 · start 2024-12-15

    Registered record
    Registry ID
    NCT07307625
    Conditions
    Postoperative Pain Management; Postoperative Nausea and Vomiting; Laparoscopic Cholecystectomy; Opioid-free Anesthesia; General Anesthesia
    Interventions
    Lidocaine + Dexmedetomidine; Remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-12-15
    Completion
    2025-12-01
    Enrolment
    101

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain Management; Postoperative Nausea and Vomiting; Laparoscopic Cholecystectomy; Opioid-free Anesthesia +1 more
    InterventionLidocaine + Dexmedetomidine; Remifentanil
    PhaseNot applicable
    Registry statusCompleted

  • Evaluation and Comparison Between General Anesthesia VS Two Types of Combined Anesthesia for Opioid Consumption in Laparoscopic Hysterectomy

    NCT06642649 · start 2024-11-01

    Registered record
    Registry ID
    NCT06642649
    Conditions
    Laparoscopic Hysterectomy; Gynecology
    Interventions
    General Anesthesia (control group); General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and no fentanyl); General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and 20 mcg fentanyl)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-11-01
    Completion
    2026-12-30
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparoscopic Hysterectomy; Gynecology
    InterventionGeneral Anesthesia (control group); General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and no fentanyl); General Anesthesia + Spinal anesthesia combined (local anesthetic, morfine and 20 mcg fentanyl)
    PhaseNot applicable
    Registry statusRecruiting

  • General Anesthesia vs Local Anesthesia for Endovascular Treatment in Patients With Unruptured Intracranial Aneurysm Using Flow Diverter

    NCT06416657 · start 2024-06-01

    Registered record
    Registry ID
    NCT06416657
    Conditions
    Intracranial Aneurysm
    Interventions
    Different anesthesia methods, namely local anesthesia and general anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-06-01
    Completion
    2026-12-01
    Enrolment
    188

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracranial Aneurysm
    InterventionDifferent anesthesia methods, namely local anesthesia and general anesthesia
    PhaseNot applicable
    Registry statusRecruiting

  • Sevoflurane and Dexmedetomidine's Contrasting Renal Impacts After Non-Cardiac Surgery

    NCT06835010 · start 2024-05-20

    Registered record
    Registry ID
    NCT06835010
    Conditions
    AKI - Acute Kidney Injury
    Interventions
    Dexmedetomidine; Sevoflurane inhalant product
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-05-20
    Completion
    2024-12-17
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAKI - Acute Kidney Injury
    InterventionDexmedetomidine; Sevoflurane inhalant product
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Neuromuscular Recovery at the Hand and Foot

    NCT06236763 · start 2024-03-01

    Registered record
    Registry ID
    NCT06236763
    Conditions
    Neuromuscular Blockade
    Interventions
    TOFscan foot
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2024-03-01
    Completion
    2024-07-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade
    InterventionTOFscan foot
    PhaseNot recorded
    Registry statusUnknown

  • Effects of Pretreatment With Different Doses of Lidocaine on Injection Pain

    NCT06865300 · start 2023-07-01

    Registered record
    Registry ID
    NCT06865300
    Conditions
    Rocuronium Adverse Reaction; Lidocaine Adverse Reaction
    Interventions
    Lidocain 40 mg; lidocain 1 mg/kg; serum physiologic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-07-01
    Completion
    2023-12-31
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRocuronium Adverse Reaction; Lidocaine Adverse Reaction
    InterventionLidocain 40 mg; lidocain 1 mg/kg; serum physiologic
    PhaseNot applicable
    Registry statusCompleted

  • Researching the Affect of Sevoflurane in Cardiac Surgery on Delirium

    NCT05365165 · start 2022-03-15

    Registered record
    Registry ID
    NCT05365165
    Conditions
    Postoperative Delirium
    Interventions
    Sevoflurane
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2022-03-15
    Completion
    2022-10
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Delirium
    InterventionSevoflurane
    PhaseNot recorded
    Registry statusUnknown

  • A Pharmacokinetic Study of Sugammadex in Dialysis Patients

    NCT04556721 · start 2021-09-10

    Registered record
    Registry ID
    NCT04556721
    Conditions
    Renal Disease
    Interventions
    Sugammadex
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2021-09-10
    Completion
    2021-09-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Disease
    InterventionSugammadex
    PhasePhase 1
    Registry statusWithdrawn