Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Rocuronium Bromide

FDA-approved product (injectable, injection), marketed as Rocuronium Bromide, Zemuron.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Rocuronium Bromide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Rocuronium Bromide. Its therapeutic class is shown instead.

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA59.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis37.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Rocuronium Bromide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Rocuronium Bromide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • The Effects of Low Flow and Normal Flow Desflurane Anesthesia

    NCT05414721 · start 2021-05-28

    Registered record
    Registry ID
    NCT05414721
    Conditions
    Anesthesia; Liver Functions; Kidney Functions; Geriatric
    Interventions
    Low flow desflurane anesthesia (Group D)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-05-28
    Completion
    2022-03-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Liver Functions; Kidney Functions; Geriatric
    InterventionLow flow desflurane anesthesia (Group D)
    PhaseNot applicable
    Registry statusCompleted

  • Induction of Anesthesia With Sevoflurane Preserving Spontaneous Breathing: Cardiorespiratory Effects.

    NCT04802122 · start 2021-05-24

    Registered record
    Registry ID
    NCT04802122
    Conditions
    Anesthesia Intubation Complication; Cardiovascular Complication; Intubation
    Interventions
    Sevoflurane inhalant product; Propofol Fresenius
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-05-24
    Completion
    2021-07-14
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia Intubation Complication; Cardiovascular Complication; Intubation
    InterventionSevoflurane inhalant product; Propofol Fresenius
    PhasePhase 4
    Registry statusCompleted

  • Acupuncture for Prevention of Postoperative Nausea and Vomiting

    NCT04866121 · start 2021-05-01

    Registered record
    Registry ID
    NCT04866121
    Conditions
    PONV
    Interventions
    Acupuncture
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-05-01
    Completion
    2022-05-01
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPONV
    InterventionAcupuncture
    PhaseNot applicable
    Registry statusUnknown

  • Peribulbar Rocuronium in Adult Strabismus Surgery

    NCT04821817 · start 2021-04-03

    Registered record
    Registry ID
    NCT04821817
    Conditions
    Strabismus; Regional Anesthesia Morbidity; Rocuronium
    Interventions
    Normal saline; Rocuronium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-04-03
    Completion
    2025-02-09
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStrabismus; Regional Anesthesia Morbidity; Rocuronium
    InterventionNormal saline; Rocuronium
    PhaseNot applicable
    Registry statusCompleted

  • Position and Predictive Factors of Hypotension in Prone Percutaneous Nephrolithotomy

    NCT05827705 · start 2021-03-01

    Registered record
    Registry ID
    NCT05827705
    Conditions
    Hypotension; Urolithiasis
    Interventions
    need for Ephedrine hydrochloride
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-03-01
    Completion
    2022-04-01
    Enrolment
    153

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypotension; Urolithiasis
    Interventionneed for Ephedrine hydrochloride
    PhaseNot recorded
    Registry statusCompleted

  • Comparison of Conventional Fluid Management Protocol With Targeted Pleth Variability Index (PVI) Monitoring Protocol During Total Abdominal Hysterectomy and Bilateral Salpingooferectomy Operation

    NCT04775576 · start 2021-02-25

    Registered record
    Registry ID
    NCT04775576
    Conditions
    Intraoperative Hypotension; Intraoperative Complications; Hypervolemia; Acute Renal Failure; Perioperative/Postoperative Complications; Volume Overload
    Interventions
    Pleth Variability Index; Conventional fluid theraphy; Anesthesia method
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-02-25
    Completion
    2021-07-12
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntraoperative Hypotension; Intraoperative Complications; Hypervolemia; Acute Renal Failure +2 more
    InterventionPleth Variability Index; Conventional fluid theraphy; Anesthesia method
    PhaseNot applicable
    Registry statusCompleted

  • Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

    NCT04532606 · start 2021-02-05

    Registered record
    Registry ID
    NCT04532606
    Conditions
    Benzodiazepines; Bladder Cancer; Delirium; Surgery; Cancer Recurrence
    Interventions
    Remimazolam; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2021-02-05
    Completion
    2026-10
    Enrolment
    1,128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenzodiazepines; Bladder Cancer; Delirium; Surgery +1 more
    InterventionRemimazolam; Propofol
    PhasePhase 4
    Registry statusRecruiting

  • Opioid-free Anesthesia in Gynecologic Surgery

    NCT04700761 · start 2021-02-01

    Registered record
    Registry ID
    NCT04700761
    Conditions
    Gynecologic Disease
    Interventions
    Opioid-free anesthesia; Opioid-using anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-02-01
    Completion
    2022-07-30
    Enrolment
    164

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGynecologic Disease
    InterventionOpioid-free anesthesia; Opioid-using anesthesia
    PhaseNot applicable
    Registry statusUnknown

  • Determinants on Rocuronium Dose for Deep Block in Bariatric Surgery

    NCT04709406 · start 2021-01

    Registered record
    Registry ID
    NCT04709406
    Conditions
    Bariatric Surgery
    Interventions
    deep neuromuscular blockade in bariatric surgery
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2021-01
    Completion
    2021-10
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBariatric Surgery
    Interventiondeep neuromuscular blockade in bariatric surgery
    PhaseNot recorded
    Registry statusUnknown

  • Reversal of Neuromuscular Blockade During the General Anaesthesia

    NCT04048655 · start 2020-04-08

    Registered record
    Registry ID
    NCT04048655
    Conditions
    Neuromuscular Blockade
    Interventions
    Neostigmine, Combinations
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2020-04-08
    Completion
    2025-12-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade
    InterventionNeostigmine, Combinations
    PhaseNot applicable
    Registry statusActive not recruiting

  • Impact of Deep Versus Standard Muscle Relaxation on Intra-operative Safety

    NCT04124757 · start 2020-02-11

    Registered record
    Registry ID
    NCT04124757
    Conditions
    Neuromuscular Blockade; Rocuronium; Anesthetics; Anesthesia Complication; Neuromuscular Blocking Agents; Surgery--Complications
    Interventions
    Deep neuromuscular block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-02-11
    Completion
    2024-06-01
    Enrolment
    731

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade; Rocuronium; Anesthetics; Anesthesia Complication +2 more
    InterventionDeep neuromuscular block
    PhaseNot applicable
    Registry statusCompleted

  • Neuromuscular Blocking Agents in the Elderly

    NCT03857750 · start 2019-03-27

    Registered record
    Registry ID
    NCT03857750
    Conditions
    Elective Surgery
    Interventions
    Rocuronium
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2019-03-27
    Completion
    2019-10-08
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionElective Surgery
    InterventionRocuronium
    PhaseNot recorded
    Registry statusCompleted

  • Pupillometry - Future of Objective Pain Reaction Measurement While Unconscious

    NCT04000126 · start 2019-02-25

    Registered record
    Registry ID
    NCT04000126
    Conditions
    Pain
    Interventions
    Pupil reflex dilation measurement (PRD); PPI (Pupillary Pain Index); lidocaine; Placebo; Bispectral Index (BIS); HR; BP
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-02-25
    Completion
    2019-12-31
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionPupil reflex dilation measurement (PRD); PPI (Pupillary Pain Index); lidocaine; Placebo +3 more
    PhaseNot applicable
    Registry statusCompleted

  • Muscle Relax Affects Outcomes of Robotic Surgery

    NCT03726372 · start 2018-11-10

    Registered record
    Registry ID
    NCT03726372
    Conditions
    General Anesthesia; Postoperative Complications
    Interventions
    Rocuronium; continuous infusion; intermittent injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-11-10
    Completion
    2019-11-10
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneral Anesthesia; Postoperative Complications
    InterventionRocuronium; continuous infusion; intermittent injection
    PhaseNot applicable
    Registry statusUnknown

  • Does Depth of Neuromuscular Blockade (NMB) Affect Surgical Conditions in Obese Patients Undergoing Robotic Surgery

    NCT03591289 · start 2018-02

    Registered record
    Registry ID
    NCT03591289
    Conditions
    GYN Disorders; Urologic Diseases
    Interventions
    NMB with rocuronium bromide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2018-02
    Completion
    2018-07-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGYN Disorders; Urologic Diseases
    InterventionNMB with rocuronium bromide
    PhasePhase 4
    Registry statusWithdrawn