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AMR Drug RepurposingSmart Screeningresearch prototype

Rocuronium Bromide

FDA-approved product (injectable, injection), marketed as Rocuronium Bromide, Zemuron.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Rocuronium Bromide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Rocuronium Bromide. Its therapeutic class is shown instead.

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA59.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis37.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Rocuronium Bromide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Rocuronium Bromide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Opioid Free Anesthesia and Major Spine Surgery

    NCT03417193 · start 2018-01-29

    Registered record
    Registry ID
    NCT03417193
    Conditions
    Opioid Use; Postoperative Pain; Spine Disease
    Interventions
    opioid free Anesthesia vs Opioid based Anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-01-29
    Completion
    2023-02-16
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Use; Postoperative Pain; Spine Disease
    Interventionopioid free Anesthesia vs Opioid based Anesthesia
    PhaseNot applicable
    Registry statusCompleted

  • Effect of NMBA on Surgical Conditions in THR

    NCT03369782 · start 2017-12-15

    Registered record
    Registry ID
    NCT03369782
    Conditions
    Surgery; Postoperative Pain
    Interventions
    Rocuronium; Sugammadex; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2017-12-15
    Completion
    2018-05-31
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgery; Postoperative Pain
    InterventionRocuronium; Sugammadex; Placebo
    PhasePhase 4
    Registry statusWithdrawn

  • Validation of the TOF Cuff Monitor® Which Measures Neuromuscular Block on the Upper Arm

    NCT03256955 · start 2017-06-23

    Registered record
    Registry ID
    NCT03256955
    Conditions
    Neuromuscular Blockade
    Interventions
    Tof cuff; Tof Watch SX
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-06-23
    Completion
    2018-05-14
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade
    InterventionTof cuff; Tof Watch SX
    PhaseNot applicable
    Registry statusCompleted

  • Intraoperative Protective Ventilation for Obese Patients Undergoing Gynaecological Laparoscopic Surgery

    NCT03157479 · start 2017-05-01

    Registered record
    Registry ID
    NCT03157479
    Conditions
    Anesthesia; Surgery--Complications
    Interventions
    Intravenous anesthetic; Crystalloid Solutions; Esophageal pressure measurement; Lung volume measurement with the nitrogen washin-washout technique
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-05-01
    Completion
    2019-03-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Surgery--Complications
    InterventionIntravenous anesthetic; Crystalloid Solutions; Esophageal pressure measurement; Lung volume measurement with the nitrogen washin-washout technique
    PhaseNot applicable
    Registry statusCompleted

  • Surgical Conditions During Laparoscopic Bariatric Surgery

    NCT02703909 · start 2016-05

    Registered record
    Registry ID
    NCT02703909
    Conditions
    Morbid Obesity
    Interventions
    Rocuronium; Insufflation pressure
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-05
    Completion
    2017-10
    Enrolment
    144

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMorbid Obesity
    InterventionRocuronium; Insufflation pressure
    PhasePhase 4
    Registry statusCompleted

  • Peroperative Use of Positive End-expiratory Pressure Prevents Formation of Atelectasis as Studied by Computerised Tomography at End of Surgery

    NCT02548416 · start 2015-11

    Registered record
    Registry ID
    NCT02548416
    Conditions
    Atelectasis
    Interventions
    Positive end-expiratory pressure; Control group, zero PEEP
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-11
    Completion
    2016-11
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtelectasis
    InterventionPositive end-expiratory pressure; Control group, zero PEEP
    PhaseNot applicable
    Registry statusCompleted

  • Electromyographic Activity of the Respiratory Muscles During Neostigmine or Sugammadex Enhanced Recovery After Neuromuscular Blockade

    NCT02403063 · start 2015-09

    Registered record
    Registry ID
    NCT02403063
    Conditions
    Respiratory Muscles; Electromyography
    Interventions
    Sugammadex; Neostigmine; Neostigmine-sugammadex
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-09
    Completion
    2015-11
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Muscles; Electromyography
    InterventionSugammadex; Neostigmine; Neostigmine-sugammadex
    PhasePhase 4
    Registry statusCompleted

  • Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy

    NCT02320734 · start 2015-02

    Registered record
    Registry ID
    NCT02320734
    Conditions
    Neuromuscular Block; Esophageal Cancer; Surgery
    Interventions
    Rocuronium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-02
    Completion
    2016-09
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Block; Esophageal Cancer; Surgery
    InterventionRocuronium
    PhasePhase 4
    Registry statusCompleted

  • The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy

    NCT02109133 · start 2014-05

    Registered record
    Registry ID
    NCT02109133
    Conditions
    Robot-Assisted Laparoscopic Radical Prostatectomy
    Interventions
    deep neuromuscular blockade; moderate neuromuscular blockade; Rocuronium; Sugammadex; Atracurium; Neostigmine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-05
    Completion
    2014-12
    Enrolment
    67

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRobot-Assisted Laparoscopic Radical Prostatectomy
    Interventiondeep neuromuscular blockade; moderate neuromuscular blockade; Rocuronium; Sugammadex +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Deep Neuromuscular Block (NMB), Inhalation or TIVA on Pneumoperitoneum.

    NCT01930747 · start 2013-04

    Registered record
    Registry ID
    NCT01930747
    Conditions
    Muscle Relaxation
    Interventions
    rocuronium; Sevoflurane; remifentanyl
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-04
    Completion
    2016-04
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMuscle Relaxation
    Interventionrocuronium; Sevoflurane; remifentanyl
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Different Sevoflurane Concentrations on Intraocular Pressure in Patients Undergoing Ocular Surgery Under General Anesthesia

    NCT01575626 · start 2012-05

    Registered record
    Registry ID
    NCT01575626
    Conditions
    IOP Changes Due to Anesthesia (Healthy Patients)
    Interventions
    Sevoflurane
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2012-05
    Completion
    Not recorded
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIOP Changes Due to Anesthesia (Healthy Patients)
    InterventionSevoflurane
    PhaseNot applicable
    Registry statusUnknown

  • Sugammadex Dosage Based on Ideal Body Weight for Profound Rocuronium-induced Neuromuscular Blockade Reversal in Morbidly Obese Patients

    NCT02545595 · start 2012-05

    Registered record
    Registry ID
    NCT02545595
    Conditions
    Morbid Obesity
    Interventions
    Sugammadex 1 mg/kg; Sugammadex 2 mg/kg; Sugammadex 4 mg/kg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-05
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMorbid Obesity
    InterventionSugammadex 1 mg/kg; Sugammadex 2 mg/kg; Sugammadex 4 mg/kg
    PhasePhase 2
    Registry statusCompleted

  • Monitored Anesthesia Care Versus Intubated General Anesthesia for Open Heart Surgery Under Cardiopulmonary Bypass

    NCT05011617 · start 2012-04-01

    Registered record
    Registry ID
    NCT05011617
    Conditions
    Monitored Anesthesia Care; Cardiac Surgery; Postoperative Recovery
    Interventions
    Non-intubation and monitoring anesthesia care (MAC)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-04-01
    Completion
    2021-12-31
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMonitored Anesthesia Care; Cardiac Surgery; Postoperative Recovery
    InterventionNon-intubation and monitoring anesthesia care (MAC)
    PhaseNot applicable
    Registry statusCompleted

  • Neuromuscular Blockade and Surgical Conditions

    NCT01564576 · start 2012-04

    Registered record
    Registry ID
    NCT01564576
    Conditions
    Morbid Obesity
    Interventions
    Profound neuromuscular blockade (Rocuronium, Rocuronium bromide, sugammadex, Bridion)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2012-04
    Completion
    2012-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMorbid Obesity
    InterventionProfound neuromuscular blockade (Rocuronium, Rocuronium bromide, sugammadex, Bridion)
    PhaseNot applicable
    Registry statusUnknown

  • Sugammadex and Smoker's Neuromuscular Block

    NCT05313100 · start 2012-04

    Registered record
    Registry ID
    NCT05313100
    Conditions
    Neuromuscular Blockade; Smoking
    Interventions
    sugammadex
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-04
    Completion
    2013-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade; Smoking
    Interventionsugammadex
    PhasePhase 4
    Registry statusCompleted