Cisatracurium Besylate
FDA-approved product (injectable, injection), marketed as Cisatracurium Besylate, Cisatracurium Besylate Preservative Free, Nimbex and 1 more.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLNo approved indication recorded
ChEMBL records no approved indication for Cisatracurium Besylate. Its therapeutic class is shown instead.
- WHO therapeutic group
- Other quaternary ammonium compounds
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA50.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli41.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae22.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Cisatracurium Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure
NCT07789275 · start 2026-08
Registered record
- Registry ID
- NCT07789275
- Conditions
- Intraoperative Hypotension; Hepatectomy
- Interventions
- Remimazolam; Propofol
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Not yet recruiting
- Start
- 2026-08
- Completion
- 2027-08
- Enrolment
- 224
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionIntraoperative Hypotension; HepatectomyInterventionRemimazolam; PropofolPhasePhase 4Registry statusNot yet recruitingScalp Block Versus General Anesthesia in Patients Undergoing Evacuation of Subdural Hematoma Via Burr Hole
NCT07143799 · start 2025-08-11
Registered record
- Registry ID
- NCT07143799
- Conditions
- Subdural Hematoma
- Interventions
- Cisatracurium; scalp block
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Recruiting
- Start
- 2025-08-11
- Completion
- 2026-03-20
- Enrolment
- 80
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSubdural HematomaInterventionCisatracurium; scalp blockPhaseNot applicableRegistry statusRecruitingMinimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal Surgery
NCT06785350 · start 2025-01-25
Registered record
- Registry ID
- NCT06785350
- Conditions
- Pain Management; Spine Surgery
- Interventions
- 0.012%diprospan+0.5%ropivacaine; 0.009%diprospan+0.5%ropivacaine; 0.006%diprospan+0.5ropivacaine; 0.003%diprospan+0.5%ropivacaine; 0.5%ropivacaine
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Recruiting
- Start
- 2025-01-25
- Completion
- 2025-12-01
- Enrolment
- 535
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPain Management; Spine SurgeryIntervention0.012%diprospan+0.5%ropivacaine; 0.009%diprospan+0.5%ropivacaine; 0.006%diprospan+0.5ropivacaine; 0.003%diprospan+0.5%ropivacaine +1 morePhaseNot applicableRegistry statusRecruitingIntubation Conditions During ERCP With Lidocaine Aerosol Plus Low-dose Cisatracurium or Conventional-dose Cisatracurium
NCT07185074 · start 2025-01-17
Registered record
- Registry ID
- NCT07185074
- Conditions
- Intubation, Intratracheal
- Interventions
- Cisatracurium 0.05 mg/kg IV; Cisatracurium 0.15 mg/kg IV; Lidocaine aerosol 2.4% topical
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2025-01-17
- Completion
- 2026-05-24
- Enrolment
- 186
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionIntubation, IntratrachealInterventionCisatracurium 0.05 mg/kg IV; Cisatracurium 0.15 mg/kg IV; Lidocaine aerosol 2.4% topicalPhasePhase 4Registry statusCompletedSpinal Versus General Anesthesia on Postoperative Pulmonary Complications
NCT06425627 · start 2024-06-12
Registered record
- Registry ID
- NCT06425627
- Conditions
- Pulmonary Complication; Anesthesia; Hip Fractures
- Interventions
- spinal anesthesia; general anesthesia
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Recruiting
- Start
- 2024-06-12
- Completion
- 2026-05-20
- Enrolment
- 40
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPulmonary Complication; Anesthesia; Hip FracturesInterventionspinal anesthesia; general anesthesiaPhaseNot applicableRegistry statusRecruitingNerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH
NCT05888389 · start 2024-04-01
Registered record
- Registry ID
- NCT05888389
- Conditions
- Chronic Subdural Hematoma; Anesthesia
- Interventions
- Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia; General Anesthesia
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2024-04-01
- Completion
- 2025-12-31
- Enrolment
- 190
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Subdural Hematoma; AnesthesiaInterventionCranial Nerve Block Anesthesia Combined With Sedative Anesthesia; General AnesthesiaPhaseNot applicableRegistry statusUnknownMid-transverse Process to Pleura Block in Pediatric Thoracotomy
NCT05999734 · start 2024-01-01
Registered record
- Registry ID
- NCT05999734
- Conditions
- Ultrasound Guided Block; Pediatric Surgery; Analgesia
- Interventions
- Bupivacaine
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2024-01-01
- Completion
- 2026-06-01
- Enrolment
- 50
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionUltrasound Guided Block; Pediatric Surgery; AnalgesiaInterventionBupivacainePhaseNot applicableRegistry statusCompletedEffect of Lidocaine Sprayed for Attenuating Hemodynamic Response During Laryngoscopy and Intubation
NCT06226532 · start 2024-01
Registered record
- Registry ID
- NCT06226532
- Conditions
- Laryngoscopy; Intubation; Hemodynamics; Neurosurgery; Lidocaine
- Interventions
- lidocaine spray; Intravenous Lidocaine
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Unknown
- Start
- 2024-01
- Completion
- 2025-05
- Enrolment
- 50
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLaryngoscopy; Intubation; Hemodynamics; Neurosurgery +1 moreInterventionlidocaine spray; Intravenous LidocainePhasePhase 4Registry statusUnknownCharacterisation of Gut Microbiota in Patients Undergoing Gastrointestinal Surgery With Postoperative Delirium (GIM-POD)
NCT04316910 · start 2023-07-19
Registered record
- Registry ID
- NCT04316910
- Conditions
- Postoperative Delirium; Gut Microbiota
- Interventions
- General anesthetic
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Unknown
- Start
- 2023-07-19
- Completion
- 2024-09-30
- Enrolment
- 30
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPostoperative Delirium; Gut MicrobiotaInterventionGeneral anestheticPhaseNot recordedRegistry statusUnknownThe Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery
NCT05810363 · start 2023-06-16
Registered record
- Registry ID
- NCT05810363
- Conditions
- Etomidate; Hypotension
- Interventions
- Etomidate - propofol mixture; Propofol
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2023-06-16
- Completion
- 2024-10-30
- Enrolment
- 468
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionEtomidate; HypotensionInterventionEtomidate - propofol mixture; PropofolPhaseNot applicableRegistry statusCompletedEffect of Addition of Cisatracurium to Lidocaine VS Plain Lidocaine
NCT06214169 · start 2023-06-15
Registered record
- Registry ID
- NCT06214169
- Conditions
- Anesthesia
- Interventions
- Cisatracurium Besylate; Lignocaine
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2023-06-15
- Completion
- 2023-12-20
- Enrolment
- 44
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAnesthesiaInterventionCisatracurium Besylate; LignocainePhaseNot applicableRegistry statusCompletedEffect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery
NCT05664386 · start 2023-04-10
Registered record
- Registry ID
- NCT05664386
- Conditions
- Hemodynamics; Postoperative Recovery; Anesthesia
- Interventions
- propofol; ciprofol
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Unknown
- Start
- 2023-04-10
- Completion
- 2024-12
- Enrolment
- 126
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHemodynamics; Postoperative Recovery; AnesthesiaInterventionpropofol; ciprofolPhasePhase 4Registry statusUnknownChoice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease
NCT05550714 · start 2022-10-15
Registered record
- Registry ID
- NCT05550714
- Conditions
- PD - Parkinson's Disease; Dexmedetomidine; Desflurane; Deep Brain Stimulation
- Interventions
- general anesthesia; Conscious sedation
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2022-10-15
- Completion
- 2024-09-30
- Enrolment
- 188
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPD - Parkinson's Disease; Dexmedetomidine; Desflurane; Deep Brain StimulationInterventiongeneral anesthesia; Conscious sedationPhaseNot applicableRegistry statusUnknownEffect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery
NCT05527314 · start 2022-08-23
Registered record
- Registry ID
- NCT05527314
- Conditions
- Emergence Agitation; Remimazolam; Sevoflurane; Pediatric Ophthalmic Surgery; Anesthesia, General
- Interventions
- Remimazolam; Sevoflurane; Fentanyl; Cisatracurium Besylate; Remifentanil
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2022-08-23
- Completion
- 2023-02-07
- Enrolment
- 110
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionEmergence Agitation; Remimazolam; Sevoflurane; Pediatric Ophthalmic Surgery +1 moreInterventionRemimazolam; Sevoflurane; Fentanyl; Cisatracurium Besylate +1 morePhaseNot applicableRegistry statusCompletedKetamine Versus Magnesium Sulfate in the Time and Awakening Quality of General Anesthesia.
NCT04360473 · start 2022-03-14
Registered record
- Registry ID
- NCT04360473
- Conditions
- Awakening, Post-Anesthesia Delayed
- Interventions
- General anesthesia; Ketamine plus general anesthesia; Magnesium sulfate plus general anesthesia; ketamine plus magnesium sulfate plus general anesthesia
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2022-03-14
- Completion
- 2025-12
- Enrolment
- 140
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAwakening, Post-Anesthesia DelayedInterventionGeneral anesthesia; Ketamine plus general anesthesia; Magnesium sulfate plus general anesthesia; ketamine plus magnesium sulfate plus general anesthesiaPhaseNot applicableRegistry statusUnknown