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AMR Drug RepurposingSmart Screeningresearch prototype

Cisatracurium Besylate

FDA-approved product (injectable, injection), marketed as Cisatracurium Besylate, Cisatracurium Besylate Preservative Free, Nimbex and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cisatracurium Besylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Cisatracurium Besylate. Its therapeutic class is shown instead.

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cisatracurium Besylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cisatracurium Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Remimazolam Versus Propofol for Maintenance of Anaesthesia During Major Hepatectomy Under Low Central Venous Pressure

    NCT07789275 · start 2026-08

    Registered record
    Registry ID
    NCT07789275
    Conditions
    Intraoperative Hypotension; Hepatectomy
    Interventions
    Remimazolam; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-08
    Completion
    2027-08
    Enrolment
    224

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntraoperative Hypotension; Hepatectomy
    InterventionRemimazolam; Propofol
    PhasePhase 4
    Registry statusNot yet recruiting

  • Scalp Block Versus General Anesthesia in Patients Undergoing Evacuation of Subdural Hematoma Via Burr Hole

    NCT07143799 · start 2025-08-11

    Registered record
    Registry ID
    NCT07143799
    Conditions
    Subdural Hematoma
    Interventions
    Cisatracurium; scalp block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-08-11
    Completion
    2026-03-20
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubdural Hematoma
    InterventionCisatracurium; scalp block
    PhaseNot applicable
    Registry statusRecruiting

  • Minimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal Surgery

    NCT06785350 · start 2025-01-25

    Registered record
    Registry ID
    NCT06785350
    Conditions
    Pain Management; Spine Surgery
    Interventions
    0.012%diprospan+0.5%ropivacaine; 0.009%diprospan+0.5%ropivacaine; 0.006%diprospan+0.5ropivacaine; 0.003%diprospan+0.5%ropivacaine; 0.5%ropivacaine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-01-25
    Completion
    2025-12-01
    Enrolment
    535

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain Management; Spine Surgery
    Intervention0.012%diprospan+0.5%ropivacaine; 0.009%diprospan+0.5%ropivacaine; 0.006%diprospan+0.5ropivacaine; 0.003%diprospan+0.5%ropivacaine +1 more
    PhaseNot applicable
    Registry statusRecruiting

  • Intubation Conditions During ERCP With Lidocaine Aerosol Plus Low-dose Cisatracurium or Conventional-dose Cisatracurium

    NCT07185074 · start 2025-01-17

    Registered record
    Registry ID
    NCT07185074
    Conditions
    Intubation, Intratracheal
    Interventions
    Cisatracurium 0.05 mg/kg IV; Cisatracurium 0.15 mg/kg IV; Lidocaine aerosol 2.4% topical
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2025-01-17
    Completion
    2026-05-24
    Enrolment
    186

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntubation, Intratracheal
    InterventionCisatracurium 0.05 mg/kg IV; Cisatracurium 0.15 mg/kg IV; Lidocaine aerosol 2.4% topical
    PhasePhase 4
    Registry statusCompleted

  • Spinal Versus General Anesthesia on Postoperative Pulmonary Complications

    NCT06425627 · start 2024-06-12

    Registered record
    Registry ID
    NCT06425627
    Conditions
    Pulmonary Complication; Anesthesia; Hip Fractures
    Interventions
    spinal anesthesia; general anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-06-12
    Completion
    2026-05-20
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Complication; Anesthesia; Hip Fractures
    Interventionspinal anesthesia; general anesthesia
    PhaseNot applicable
    Registry statusRecruiting

  • Nerve Block Anesthesia Combined With Sedative Anesthesia Versus General Anesthesia in Surgery for CSDH

    NCT05888389 · start 2024-04-01

    Registered record
    Registry ID
    NCT05888389
    Conditions
    Chronic Subdural Hematoma; Anesthesia
    Interventions
    Cranial Nerve Block Anesthesia Combined With Sedative Anesthesia; General Anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-04-01
    Completion
    2025-12-31
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Subdural Hematoma; Anesthesia
    InterventionCranial Nerve Block Anesthesia Combined With Sedative Anesthesia; General Anesthesia
    PhaseNot applicable
    Registry statusUnknown

  • Mid-transverse Process to Pleura Block in Pediatric Thoracotomy

    NCT05999734 · start 2024-01-01

    Registered record
    Registry ID
    NCT05999734
    Conditions
    Ultrasound Guided Block; Pediatric Surgery; Analgesia
    Interventions
    Bupivacaine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-01-01
    Completion
    2026-06-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUltrasound Guided Block; Pediatric Surgery; Analgesia
    InterventionBupivacaine
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Lidocaine Sprayed for Attenuating Hemodynamic Response During Laryngoscopy and Intubation

    NCT06226532 · start 2024-01

    Registered record
    Registry ID
    NCT06226532
    Conditions
    Laryngoscopy; Intubation; Hemodynamics; Neurosurgery; Lidocaine
    Interventions
    lidocaine spray; Intravenous Lidocaine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2024-01
    Completion
    2025-05
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaryngoscopy; Intubation; Hemodynamics; Neurosurgery +1 more
    Interventionlidocaine spray; Intravenous Lidocaine
    PhasePhase 4
    Registry statusUnknown

  • Characterisation of Gut Microbiota in Patients Undergoing Gastrointestinal Surgery With Postoperative Delirium (GIM-POD)

    NCT04316910 · start 2023-07-19

    Registered record
    Registry ID
    NCT04316910
    Conditions
    Postoperative Delirium; Gut Microbiota
    Interventions
    General anesthetic
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2023-07-19
    Completion
    2024-09-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Delirium; Gut Microbiota
    InterventionGeneral anesthetic
    PhaseNot recorded
    Registry statusUnknown

  • The Safety of Etomidate - Propofol Mixture vs Propofol in Total Intravenous Anesthesia During Abdominal Surgery

    NCT05810363 · start 2023-06-16

    Registered record
    Registry ID
    NCT05810363
    Conditions
    Etomidate; Hypotension
    Interventions
    Etomidate - propofol mixture; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-06-16
    Completion
    2024-10-30
    Enrolment
    468

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEtomidate; Hypotension
    InterventionEtomidate - propofol mixture; Propofol
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Addition of Cisatracurium to Lidocaine VS Plain Lidocaine

    NCT06214169 · start 2023-06-15

    Registered record
    Registry ID
    NCT06214169
    Conditions
    Anesthesia
    Interventions
    Cisatracurium Besylate; Lignocaine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-06-15
    Completion
    2023-12-20
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia
    InterventionCisatracurium Besylate; Lignocaine
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Ciprofol Infusion for Induction and Maintenance on Hemodynamics and Postoperative Recovery

    NCT05664386 · start 2023-04-10

    Registered record
    Registry ID
    NCT05664386
    Conditions
    Hemodynamics; Postoperative Recovery; Anesthesia
    Interventions
    propofol; ciprofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2023-04-10
    Completion
    2024-12
    Enrolment
    126

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemodynamics; Postoperative Recovery; Anesthesia
    Interventionpropofol; ciprofol
    PhasePhase 4
    Registry statusUnknown

  • Choice of Anesthesia in Microelectrode Recording Guided Deep Brain Stimulation for Parkinson's Disease

    NCT05550714 · start 2022-10-15

    Registered record
    Registry ID
    NCT05550714
    Conditions
    PD - Parkinson's Disease; Dexmedetomidine; Desflurane; Deep Brain Stimulation
    Interventions
    general anesthesia; Conscious sedation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-10-15
    Completion
    2024-09-30
    Enrolment
    188

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPD - Parkinson's Disease; Dexmedetomidine; Desflurane; Deep Brain Stimulation
    Interventiongeneral anesthesia; Conscious sedation
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery

    NCT05527314 · start 2022-08-23

    Registered record
    Registry ID
    NCT05527314
    Conditions
    Emergence Agitation; Remimazolam; Sevoflurane; Pediatric Ophthalmic Surgery; Anesthesia, General
    Interventions
    Remimazolam; Sevoflurane; Fentanyl; Cisatracurium Besylate; Remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-08-23
    Completion
    2023-02-07
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEmergence Agitation; Remimazolam; Sevoflurane; Pediatric Ophthalmic Surgery +1 more
    InterventionRemimazolam; Sevoflurane; Fentanyl; Cisatracurium Besylate +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Ketamine Versus Magnesium Sulfate in the Time and Awakening Quality of General Anesthesia.

    NCT04360473 · start 2022-03-14

    Registered record
    Registry ID
    NCT04360473
    Conditions
    Awakening, Post-Anesthesia Delayed
    Interventions
    General anesthesia; Ketamine plus general anesthesia; Magnesium sulfate plus general anesthesia; ketamine plus magnesium sulfate plus general anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-03-14
    Completion
    2025-12
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAwakening, Post-Anesthesia Delayed
    InterventionGeneral anesthesia; Ketamine plus general anesthesia; Magnesium sulfate plus general anesthesia; ketamine plus magnesium sulfate plus general anesthesia
    PhaseNot applicable
    Registry statusUnknown