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AMR Drug RepurposingSmart Screeningresearch prototype

Cisatracurium Besylate

FDA-approved product (injectable, injection), marketed as Cisatracurium Besylate, Cisatracurium Besylate Preservative Free, Nimbex and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cisatracurium Besylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Cisatracurium Besylate. Its therapeutic class is shown instead.

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cisatracurium Besylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cisatracurium Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Comparison for the Effect of Neuromuscular Blocking Agents Versus Sedation Alone on Severe ARDS Patients Due to COVID-19

    NCT04922814 · start 2021-08-01

    Registered record
    Registry ID
    NCT04922814
    Conditions
    COVID-19 Acute Respiratory Distress Syndrome; Sedation Complication; ICU Acquired Weakness
    Interventions
    muscle relaxation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-08-01
    Completion
    2022-08-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID-19 Acute Respiratory Distress Syndrome; Sedation Complication; ICU Acquired Weakness
    Interventionmuscle relaxation
    PhaseNot applicable
    Registry statusCompleted

  • Trial of Therapeutic Hypothermia in Patients With ARDS

    NCT04545424 · start 2021-06-29

    Registered record
    Registry ID
    NCT04545424
    Conditions
    Respiratory Distress Syndrome, Adult
    Interventions
    Hypothermia; Neuromuscular Blocking Agents; Standard of care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2021-06-29
    Completion
    2026-09-30
    Enrolment
    340

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Distress Syndrome, Adult
    InterventionHypothermia; Neuromuscular Blocking Agents; Standard of care
    PhasePhase 2
    Registry statusActive not recruiting

  • Analgesic Effect of Quadratus Lumborum Block in Laparoscopic Hemicolectomy

    NCT04848363 · start 2021-06-16

    Registered record
    Registry ID
    NCT04848363
    Conditions
    Post Operative Pain
    Interventions
    Quadratus lumborum block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-06-16
    Completion
    2022-05-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Operative Pain
    InterventionQuadratus lumborum block
    PhaseNot applicable
    Registry statusUnknown

  • Reversal of Moderate or Superficial Neuromuscular Blockade Induced by Cisatracurium

    NCT04920682 · start 2021-06-01

    Registered record
    Registry ID
    NCT04920682
    Conditions
    Neostigmine; Neuromuscular Blocking Agents; Muscle Weakness
    Interventions
    Reversal of moderate neuromuscular blockade; Reversal of superficial neuromuscular blockade; Two-step reversal; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-06-01
    Completion
    2021-08-21
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeostigmine; Neuromuscular Blocking Agents; Muscle Weakness
    InterventionReversal of moderate neuromuscular blockade; Reversal of superficial neuromuscular blockade; Two-step reversal; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Effect of S-ketamine Anesthetic on Inflammatory Response in Septic Patients Undergoing Abdominal Surgery

    NCT04873479 · start 2021-05-10

    Registered record
    Registry ID
    NCT04873479
    Conditions
    Sepsis; Acute Lung Injury
    Interventions
    S-ketamine; saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-05-10
    Completion
    2023-10-30
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis; Acute Lung Injury
    InterventionS-ketamine; saline
    PhaseNot applicable
    Registry statusUnknown

  • Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

    NCT04532606 · start 2021-02-05

    Registered record
    Registry ID
    NCT04532606
    Conditions
    Benzodiazepines; Bladder Cancer; Delirium; Surgery; Cancer Recurrence
    Interventions
    Remimazolam; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2021-02-05
    Completion
    2026-10
    Enrolment
    1,128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenzodiazepines; Bladder Cancer; Delirium; Surgery +1 more
    InterventionRemimazolam; Propofol
    PhasePhase 4
    Registry statusRecruiting

  • Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2

    NCT04998253 · start 2020-10-01

    Registered record
    Registry ID
    NCT04998253
    Conditions
    Hypoxic Pulmonary Vasoconstriction; Hypoxemia; Acute Respiratory Distress Syndrome; SARS-CoV-2 Acute Respiratory Disease
    Interventions
    Effects in oxygenation and hypoxic pulmonary vasoconstriction
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2020-10-01
    Completion
    2021-05-15
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypoxic Pulmonary Vasoconstriction; Hypoxemia; Acute Respiratory Distress Syndrome; SARS-CoV-2 Acute Respiratory Disease
    InterventionEffects in oxygenation and hypoxic pulmonary vasoconstriction
    PhaseEarly phase 1
    Registry statusCompleted

  • High Flow Nasal Cannula Oxygen During Sedation for Video-assisted Thoracoscopic Surgery

    NCT04520568 · start 2020-08-01

    Registered record
    Registry ID
    NCT04520568
    Conditions
    Chronic Obstructive Pulmonary Disease; Respiratory Failure
    Interventions
    High flow nasal cannula; CONTROL
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2020-08-01
    Completion
    2020-12-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease; Respiratory Failure
    InterventionHigh flow nasal cannula; CONTROL
    PhasePhase 2
    Registry statusUnknown

  • Opioid-free Anesthesia in VATS Lung Resection

    NCT04507165 · start 2020-08

    Registered record
    Registry ID
    NCT04507165
    Conditions
    Opioid Free Anesthesia
    Interventions
    Paravertebral block+Anterior serratus plane block; opioid free anesthesia; opioid based anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-08
    Completion
    2022-07
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Free Anesthesia
    InterventionParavertebral block+Anterior serratus plane block; opioid free anesthesia; opioid based anesthesia
    PhaseNot applicable
    Registry statusUnknown

  • Analgesic Effect of Bilateral Quadratus Lumborum Block in the End of Colorectal Laparosopic Surgery.

    NCT03966092 · start 2019-06-24

    Registered record
    Registry ID
    NCT03966092
    Conditions
    Post Operative Pain; Laparoscopic Colorectal Surgery
    Interventions
    Quadratus lumborum block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-06-24
    Completion
    2023-04-17
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Operative Pain; Laparoscopic Colorectal Surgery
    InterventionQuadratus lumborum block
    PhaseNot applicable
    Registry statusCompleted

  • Dexmedetomidine and Liver Transplantation

    NCT03770130 · start 2019-01-14

    Registered record
    Registry ID
    NCT03770130
    Conditions
    Dexmedetomidine, Liver Transplantation, Allograft Function, Survival
    Interventions
    Dexmedetomidine; Saline
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2019-01-14
    Completion
    2022-12-31
    Enrolment
    330

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDexmedetomidine, Liver Transplantation, Allograft Function, Survival
    InterventionDexmedetomidine; Saline
    PhaseEarly phase 1
    Registry statusCompleted

  • Effect of Lidocaine 1% and 2% in the Tube Cuff on Postoperative Sore Throat and Cough

    NCT03792776 · start 2019-01

    Registered record
    Registry ID
    NCT03792776
    Conditions
    Postoperative Sore Throat; Postoperative Cough
    Interventions
    cuff inflation with air; cuff inflation with lidocaine 1%; cuff inflation with lidocaine 2%; Induction of anesthesia; Maintenance of anesthesia; Endotracheal intubation; Systematic post-operative analgesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2019-01
    Completion
    2020-10
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Sore Throat; Postoperative Cough
    Interventioncuff inflation with air; cuff inflation with lidocaine 1%; cuff inflation with lidocaine 2%; Induction of anesthesia +3 more
    PhaseNot applicable
    Registry statusUnknown

  • Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS

    NCT03376854 · start 2018-05-01

    Registered record
    Registry ID
    NCT03376854
    Conditions
    Respiratory Distress Syndrome, Adult; Sars-CoV2
    Interventions
    Hypothermia; Neuromuscular Blocking Agents; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2018-05-01
    Completion
    2021-04-27
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Distress Syndrome, Adult; Sars-CoV2
    InterventionHypothermia; Neuromuscular Blocking Agents; Standard of Care
    PhasePhase 2
    Registry statusWithdrawn

  • Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage

    NCT03129009 · start 2017-04-01

    Registered record
    Registry ID
    NCT03129009
    Conditions
    Balanced Anesthesia; Intracerebral Hemorrhage; Total Intravenous Anesthesia
    Interventions
    Total intravenous anesthesia group; Balanced anesthesia group
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-04-01
    Completion
    2018-06-01
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBalanced Anesthesia; Intracerebral Hemorrhage; Total Intravenous Anesthesia
    InterventionTotal intravenous anesthesia group; Balanced anesthesia group
    PhaseNot applicable
    Registry statusUnknown

  • Effect of General Anesthesia and Mechanical Ventilation on Plasma Metabolite in Patient With Colorectal Cancer Resection

    NCT03137628 · start 2017-03-20

    Registered record
    Registry ID
    NCT03137628
    Conditions
    Metabolomics
    Interventions
    colectomy, GA and MV
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2017-03-20
    Completion
    2017-05-15
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolomics
    Interventioncolectomy, GA and MV
    PhaseNot recorded
    Registry statusUnknown