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AMR Drug RepurposingSmart Screeningresearch prototype

Cisatracurium Besylate

FDA-approved product (injectable, injection), marketed as Cisatracurium Besylate, Cisatracurium Besylate Preservative Free, Nimbex and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cisatracurium Besylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Cisatracurium Besylate. Its therapeutic class is shown instead.

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cisatracurium Besylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cisatracurium Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Randomization to Neuromuscular Blockade on Physical Functional Impairment and Recovery in ARDS

    NCT03038906 · start 2017-01

    Registered record
    Registry ID
    NCT03038906
    Conditions
    Acute Respiratory Distress Syndrome; Neuromyopathies
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2017-01
    Completion
    2020-09
    Enrolment
    290

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Respiratory Distress Syndrome; Neuromyopathies
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Anesthesia Depth's Influence on Postoperative Delirium

    NCT02972762 · start 2016-11

    Registered record
    Registry ID
    NCT02972762
    Conditions
    Femur Head Necrosis
    Interventions
    Diprivan
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2016-11
    Completion
    2018-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFemur Head Necrosis
    InterventionDiprivan
    PhaseEarly phase 1
    Registry statusUnknown

  • Use of Neuromuscular Blocking Agents and Neuromuscular Monitoring in 7 Danish Teaching Hospitals

    NCT02914119 · start 2016-10-01

    Registered record
    Registry ID
    NCT02914119
    Conditions
    Neuromuscular Blockade
    Interventions
    Rocuronium; Succinylcholine; Cisatracurium; Mivacurium; Objective neuromuscular monitoring (acceleromyography); Sugammadex; Neostigmine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-10-01
    Completion
    2017-06-01
    Enrolment
    30,430

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade
    InterventionRocuronium; Succinylcholine; Cisatracurium; Mivacurium +3 more
    PhaseNot recorded
    Registry statusCompleted

  • Effect of Neuromuscular Blockade on Pulmonary Complications in Elective Cardiac Surgery

    NCT02635542 · start 2016-03

    Registered record
    Registry ID
    NCT02635542
    Conditions
    Neuromuscular Blockade; Postoperative Complications
    Interventions
    Succinylcholine; Cisatracurium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-03
    Completion
    2017-09-15
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade; Postoperative Complications
    InterventionSuccinylcholine; Cisatracurium
    PhasePhase 4
    Registry statusCompleted

  • Reevaluation Of Systemic Early Neuromuscular Blockade

    NCT02509078 · start 2016-01-04

    Registered record
    Registry ID
    NCT02509078
    Conditions
    Acute Respiratory Distress Syndrome
    Interventions
    Cisatracurium Besylate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-01-04
    Completion
    2019-04-04
    Enrolment
    1,008

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Respiratory Distress Syndrome
    InterventionCisatracurium Besylate
    PhasePhase 3
    Registry statusCompleted

  • Laparoscopic Surgery and Abdominal Compliance

    NCT02816567 · start 2016-01

    Registered record
    Registry ID
    NCT02816567
    Conditions
    Patients Ongoing Elective Abdominal Laparoscopy
    Interventions
    propofol; NMBA - cisatracurium; placebo - isotonic saline serum; sufentanil; laparoscopic surgery
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-01
    Completion
    Not recorded
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients Ongoing Elective Abdominal Laparoscopy
    Interventionpropofol; NMBA - cisatracurium; placebo - isotonic saline serum; sufentanil +1 more
    PhasePhase 4
    Registry statusUnknown

  • Rocuronium + Sugammadex vs. Succinylcholine + Cisatracurium + Neostigmine/Atropine in Obese Participants (MK-8616-104)

    NCT02410590 · start 2015-07

    Registered record
    Registry ID
    NCT02410590
    Conditions
    Neuromuscular Blockade
    Interventions
    Rocuronium; Sugammadex; Cisatracurium; Neostigmine/Atropine; Succinylcholine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2015-07
    Completion
    2016-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuromuscular Blockade
    InterventionRocuronium; Sugammadex; Cisatracurium; Neostigmine/Atropine +1 more
    PhasePhase 4
    Registry statusWithdrawn

  • Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis

    NCT02194855 · start 2015-01-01

    Registered record
    Registry ID
    NCT02194855
    Conditions
    C.Delivery; Surgery (Previous), Gynecological
    Interventions
    rocuronium; cisatracurium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-01-01
    Completion
    2016-06-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionC.Delivery; Surgery (Previous), Gynecological
    Interventionrocuronium; cisatracurium
    PhasePhase 4
    Registry statusCompleted

  • A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients

    NCT02147678 · start 2014-12

    Registered record
    Registry ID
    NCT02147678
    Conditions
    Hysteroscopy; Hemodynamics; Sedation
    Interventions
    Etomidate; Propofol; Remifentanil; Anesthesia induction
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-12
    Completion
    2015-02
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHysteroscopy; Hemodynamics; Sedation
    InterventionEtomidate; Propofol; Remifentanil; Anesthesia induction
    PhasePhase 4
    Registry statusUnknown

  • Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients

    NCT02224443 · start 2014-09

    Registered record
    Registry ID
    NCT02224443
    Conditions
    Postoperative Cognitive Dysfunction
    Interventions
    dexmedetomidine; dexmedetomidine; normal saline; midazolam,fentanyl,etomidate,Cisatracurium besylate; cisatracurium besylate,propofol,remifentanil,sevoflurane
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-09
    Completion
    2015-09
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Cognitive Dysfunction
    Interventiondexmedetomidine; dexmedetomidine; normal saline; midazolam,fentanyl,etomidate,Cisatracurium besylate +1 more
    PhasePhase 4
    Registry statusUnknown

  • Dexmedetomidine Combined With the Closed Loop of Target Controlled Infusion of Propofol for Anesthesia With Intraoperative Wake up

    NCT02143362 · start 2014-06

    Registered record
    Registry ID
    NCT02143362
    Conditions
    Anesthesia; Reaction
    Interventions
    Anesthesia induction,propofol, remifentanil ,cisatracurium; Anesthesia maintenance , propofol,remifentanil,cisatracurium; Awaken test
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-06
    Completion
    Not recorded
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Reaction
    InterventionAnesthesia induction,propofol, remifentanil ,cisatracurium; Anesthesia maintenance , propofol,remifentanil,cisatracurium; Awaken test
    PhasePhase 4
    Registry statusUnknown

  • Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients

    NCT02154074 · start 2014-05

    Registered record
    Registry ID
    NCT02154074
    Conditions
    Perioperative Blood Glucose and Insulin
    Interventions
    general anesthesia induction; Isoflurane; Dexmedetomidine; normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-05
    Completion
    2014-10
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerioperative Blood Glucose and Insulin
    Interventiongeneral anesthesia induction; Isoflurane; Dexmedetomidine; normal saline
    PhasePhase 4
    Registry statusUnknown

  • Optimal Dose of Combination of Rocuronium and Cisatracurium

    NCT02495038 · start 2014-03

    Registered record
    Registry ID
    NCT02495038
    Conditions
    Chronic Otitis Media; Anesthesia
    Interventions
    10% reduction of combination of Esmeron® and Nimbex®; 20% reduction of combination of Esmeron® and Nimbex®
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-03
    Completion
    2015-02
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Otitis Media; Anesthesia
    Intervention10% reduction of combination of Esmeron® and Nimbex®; 20% reduction of combination of Esmeron® and Nimbex®
    PhaseNot applicable
    Registry statusCompleted

  • Appropriate Dose of Neostigmine for Reversal of Rocuronium and Cisatracurium

    NCT01885715 · start 2013-06

    Registered record
    Registry ID
    NCT01885715
    Conditions
    Observation of Neuromuscular Block
    Interventions
    Injection of neostigmine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-06
    Completion
    2014-06
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObservation of Neuromuscular Block
    InterventionInjection of neostigmine
    PhaseNot applicable
    Registry statusCompleted

  • Endotracheal Intubation Without Muscle Relaxants

    NCT03112564 · start 2013-03-01

    Registered record
    Registry ID
    NCT03112564
    Conditions
    Muscle Relaxation; Intubation Complication
    Interventions
    Avoidance of rocuronium/cisatracurium; Sevoflurane 8% + Intravenous fentanyl
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-03-01
    Completion
    2014-12-15
    Enrolment
    91

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMuscle Relaxation; Intubation Complication
    InterventionAvoidance of rocuronium/cisatracurium; Sevoflurane 8% + Intravenous fentanyl
    PhaseNot applicable
    Registry statusCompleted