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AMR Drug RepurposingSmart Screeningresearch prototype

Atracurium Besylate

FDA-approved product (injectable, injection), marketed as Atracurium Besylate, Atracurium Besylate Preservative Free, Tracrium and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Atracurium Besylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Neuromuscular Blockade

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Atracurium Besylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Atracurium Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Quadratus Lumborum Versus Transversus Abdominis Plane Block Versus Caudal Block for Postoperative Analgesia After Pediatric Inguinal Hernia : Double-Blinded Randomized Trial

    NCT05442905 · start 2022-08-01

    Registered record
    Registry ID
    NCT05442905
    Conditions
    Quadratus Lumborum Block; Transversus Abdominis Plane Block; Caudal Block; Postoperative Pain; Inguinal Hernia
    Interventions
    propofol; Atracurium Besylate; sevoflurane
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-08-01
    Completion
    2023-03-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionQuadratus Lumborum Block; Transversus Abdominis Plane Block; Caudal Block; Postoperative Pain +1 more
    Interventionpropofol; Atracurium Besylate; sevoflurane
    PhaseNot applicable
    Registry statusUnknown

  • Dexamethasone As Adjuvant for Pre - emptiveTransversusAbdominus Muscle Plane Block

    NCT06970548 · start 2022-06-01

    Registered record
    Registry ID
    NCT06970548
    Conditions
    Post Operative Pain
    Interventions
    Levobupivacaine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-06-01
    Completion
    2023-06-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Operative Pain
    InterventionLevobupivacaine
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Esketamine-Propofol and Fentanyl-Propofol

    NCT05752409 · start 2021-10-08

    Registered record
    Registry ID
    NCT05752409
    Conditions
    Hemodynamics
    Interventions
    The median dose of esketamine; The high dose of esketamine; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-10-08
    Completion
    2023-12-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemodynamics
    InterventionThe median dose of esketamine; The high dose of esketamine; Propofol
    PhaseNot applicable
    Registry statusUnknown

  • Awareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique

    NCT05019560 · start 2021-09-05

    Registered record
    Registry ID
    NCT05019560
    Conditions
    Awareness, Anesthesia; Recall Phenomenon; Inhalation; Gas
    Interventions
    Sevoflurane; TIVA
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-09-05
    Completion
    2021-11-15
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAwareness, Anesthesia; Recall Phenomenon; Inhalation; Gas
    InterventionSevoflurane; TIVA
    PhasePhase 4
    Registry statusCompleted

  • Comparison Between a Two Person Insertion With Lateral Rotation Technique of LMA and the Classic Technique

    NCT05084612 · start 2021-08-02

    Registered record
    Registry ID
    NCT05084612
    Conditions
    Airway Complication of Anesthesia
    Interventions
    standard LMA insertion; New technique LMA insertion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Suspended
    Start
    2021-08-02
    Completion
    2025-12-25
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAirway Complication of Anesthesia
    Interventionstandard LMA insertion; New technique LMA insertion
    PhaseNot applicable
    Registry statusSuspended

  • Pain Management of Pecto-intercostal Fascial Block Versus Intravenous Fentanyl After Pediatric Cardiac Surgery

    NCT04945694 · start 2021-08

    Registered record
    Registry ID
    NCT04945694
    Conditions
    Pediatric Patients; Congenital Heart Surgery
    Interventions
    Ultrasound-guided bilateral pecto-intercostal fascial block; Intravenous fentanyl; Propofol; Sevoflurane; Atracurium; ultrasound
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-08
    Completion
    2022-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric Patients; Congenital Heart Surgery
    InterventionUltrasound-guided bilateral pecto-intercostal fascial block; Intravenous fentanyl; Propofol; Sevoflurane +2 more
    PhaseNot applicable
    Registry statusUnknown

  • Trial of Therapeutic Hypothermia in Patients With ARDS

    NCT04545424 · start 2021-06-29

    Registered record
    Registry ID
    NCT04545424
    Conditions
    Respiratory Distress Syndrome, Adult
    Interventions
    Hypothermia; Neuromuscular Blocking Agents; Standard of care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2021-06-29
    Completion
    2026-09-30
    Enrolment
    340

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Distress Syndrome, Adult
    InterventionHypothermia; Neuromuscular Blocking Agents; Standard of care
    PhasePhase 2
    Registry statusActive not recruiting

  • Intubation Conditions With Atracurium After Three Minutes

    NCT04808440 · start 2021-03-23

    Registered record
    Registry ID
    NCT04808440
    Conditions
    Obesity Female Patients Require General Anaesthesia With Intubation and Atracurium Curarization
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-03-23
    Completion
    2021-09-07
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity Female Patients Require General Anaesthesia With Intubation and Atracurium Curarization
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Sedation or General Anesthesia During TAVR

    NCT04347603 · start 2020-12-08

    Registered record
    Registry ID
    NCT04347603
    Conditions
    Stenoses, Aortic
    Interventions
    TAVR
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-12-08
    Completion
    2024-03-20
    Enrolment
    218

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStenoses, Aortic
    InterventionTAVR
    PhaseNot applicable
    Registry statusCompleted

  • Consistency Evaluation of the qCON, qNOX Indices and Bispectral Index

    NCT04562181 · start 2020-09-30

    Registered record
    Registry ID
    NCT04562181
    Conditions
    Anesthesia Monitor; Electroencephalography; Sleep
    Interventions
    Bispectral index and qCON/qNOX monitoring
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-09-30
    Completion
    2021-11-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia Monitor; Electroencephalography; Sleep
    InterventionBispectral index and qCON/qNOX monitoring
    PhaseNot applicable
    Registry statusCompleted

  • Low-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy.

    NCT04546230 · start 2020-09-19

    Registered record
    Registry ID
    NCT04546230
    Conditions
    Laparoscopic; Nephrectomy; Anesthesia; Epidural
    Interventions
    Low-Thoracic Epidural Anesthesia; General Anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2020-09-19
    Completion
    2026-12
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaparoscopic; Nephrectomy; Anesthesia; Epidural
    InterventionLow-Thoracic Epidural Anesthesia; General Anesthesia
    PhaseNot applicable
    Registry statusRecruiting

  • Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia

    NCT05097508 · start 2020-06-20

    Registered record
    Registry ID
    NCT05097508
    Conditions
    Entropy Device and How Will Muscle Relaxants Affect it
    Interventions
    Atracurium Besylate; Rocuronium Bromide; Entropy; train of four
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2020-06-20
    Completion
    2021-10-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEntropy Device and How Will Muscle Relaxants Affect it
    InterventionAtracurium Besylate; Rocuronium Bromide; Entropy; train of four
    PhaseEarly phase 1
    Registry statusCompleted

  • Can Head Position Improve Surgical Field During Ear Surgery?

    NCT04095754 · start 2020-04-12

    Registered record
    Registry ID
    NCT04095754
    Conditions
    Intra-operative Bleeding
    Interventions
    Head-Up Position; Dexmedetomidine; Induction and maintenance of anaesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-04-12
    Completion
    2020-10-14
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntra-operative Bleeding
    InterventionHead-Up Position; Dexmedetomidine; Induction and maintenance of anaesthesia
    PhaseNot applicable
    Registry statusCompleted

  • Comparison Between the Neuromuscular Blockade Onset Monitoring and the Expectation of a Fixed Delay After Curarization on the Quality of Laryngoscopy During Intubation in Elective Surgery (MONITURARE)

    NCT03981042 · start 2019-06-14

    Registered record
    Registry ID
    NCT03981042
    Conditions
    Laryngoscopy; Anesthesic Aduction; Neuromuscular Blockade; Monitoring
    Interventions
    Monitoring
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-06-14
    Completion
    2019-08-02
    Enrolment
    108

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLaryngoscopy; Anesthesic Aduction; Neuromuscular Blockade; Monitoring
    InterventionMonitoring
    PhaseNot applicable
    Registry statusCompleted

  • Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block

    NCT03803267 · start 2019-05-01

    Registered record
    Registry ID
    NCT03803267
    Conditions
    Colorectal Cancer
    Interventions
    Erector spinae plane block; Quadratus lumborum block; Propofol; Fentanyl NCS; Atracurium Injectable Product; Endotracheal intubation; Anesthesia Maintenance; Muscle Relaxation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-05-01
    Completion
    2020-04-01
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    InterventionErector spinae plane block; Quadratus lumborum block; Propofol; Fentanyl NCS +4 more
    PhaseNot applicable
    Registry statusCompleted