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AMR Drug RepurposingSmart Screeningresearch prototype

Atracurium Besylate

FDA-approved product (injectable, injection), marketed as Atracurium Besylate, Atracurium Besylate Preservative Free, Tracrium and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Atracurium Besylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Neuromuscular Blockade

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other quaternary ammonium compounds
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Atracurium Besylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Atracurium Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Unilateral Spinal vs General Anaesthesia in Low EF Patients: A Hemodynamic Comparison

    NCT07752303 · start 2026-07-05

    Registered record
    Registry ID
    NCT07752303
    Conditions
    Hemodynamic (MAP) Stability
    Interventions
    Unilateral spinal anesthesia; General anesthesia
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Enrolling by invitation
    Start
    2026-07-05
    Completion
    2026-12
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemodynamic (MAP) Stability
    InterventionUnilateral spinal anesthesia; General anesthesia
    PhaseNot recorded
    Registry statusEnrolling by invitation

  • Comparison of Two General Anesthesia Maintenance Strategies on Intraoperative Visibility During Arthroscopic Rotator Cuff Surgery: A Randomized Trial

    NCT07628244 · start 2026-06-18

    Registered record
    Registry ID
    NCT07628244
    Conditions
    Rotator Cuff Injuries; Anesthesia, General; Arthroscopy
    Interventions
    Inhalation anesthesia; Continuous intravenous anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-06-18
    Completion
    2028-03-18
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Injuries; Anesthesia, General; Arthroscopy
    InterventionInhalation anesthesia; Continuous intravenous anesthesia
    PhaseNot applicable
    Registry statusRecruiting

  • Scalp Block Versus General Anesthesia in Patients Undergoing Evacuation of Subdural Hematoma Via Burr Hole

    NCT07143799 · start 2025-08-11

    Registered record
    Registry ID
    NCT07143799
    Conditions
    Subdural Hematoma
    Interventions
    Cisatracurium; scalp block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-08-11
    Completion
    2026-03-20
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubdural Hematoma
    InterventionCisatracurium; scalp block
    PhaseNot applicable
    Registry statusRecruiting

  • To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU.

    NCT07097441 · start 2025-03-12

    Registered record
    Registry ID
    NCT07097441
    Conditions
    Tachycardia; Hypertension; Hypoxia; Hyperventilation; Residual Paralysis, Post Anesthesia
    Interventions
    Placebo drug ( normal saline ); neostigmine (reversal agent)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2025-03-12
    Completion
    2025-06-04
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTachycardia; Hypertension; Hypoxia; Hyperventilation +1 more
    InterventionPlacebo drug ( normal saline ); neostigmine (reversal agent)
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Comparison Between the Effect of Dexmedetomidine _midazolam and ketamine_midazolam Combination

    NCT07074262 · start 2024-10-10

    Registered record
    Registry ID
    NCT07074262
    Conditions
    Postoperative Cognitive Dysfunction; Post Operative Delirium
    Interventions
    Ketamine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-10-10
    Completion
    2025-03-10
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Cognitive Dysfunction; Post Operative Delirium
    InterventionKetamine
    PhaseNot applicable
    Registry statusCompleted

  • A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor

    NCT07409935 · start 2024-04-01

    Registered record
    Registry ID
    NCT07409935
    Conditions
    Patients Undergoing Rigid Bronchoscopy
    Interventions
    Propofol saline; Propofol Dexmedetomidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2024-04-01
    Completion
    2025-10-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPatients Undergoing Rigid Bronchoscopy
    InterventionPropofol saline; Propofol Dexmedetomidine
    PhasePhase 4
    Registry statusCompleted

  • Opioid Free Anaesthesia Versus Opioid Based Anesthesia for Laparscopic Cholecystectomy

    NCT06231992 · start 2024-01-31

    Registered record
    Registry ID
    NCT06231992
    Conditions
    Opioid Use
    Interventions
    opioid anaesthesia; Opioid free anaesthesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-01-31
    Completion
    2024-07
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Use
    Interventionopioid anaesthesia; Opioid free anaesthesia
    PhaseNot applicable
    Registry statusUnknown

  • Propofol-Fentanyl-Dexmedetomidine and Propofol-Fentanyl-Sevoflurane Anesthesia for Major Spine Surgery Under Somato Sensory- and Motor- Evoked Potential Monitoring

    NCT06210061 · start 2024-01-20

    Registered record
    Registry ID
    NCT06210061
    Conditions
    Propofol; Fentanyl; Dexmedetomidine; Sevoflurane; Spine Surgery; Somatosensory Evoked Potential; Motor Evoked Potential
    Interventions
    Propofol-Fentanyl; Propofol-Fentanyl-Dexmedetomidine; Propofol-Fentanyl-Sevoflurane
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-01-20
    Completion
    2025-04-01
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPropofol; Fentanyl; Dexmedetomidine; Sevoflurane +3 more
    InterventionPropofol-Fentanyl; Propofol-Fentanyl-Dexmedetomidine; Propofol-Fentanyl-Sevoflurane
    PhaseNot applicable
    Registry statusCompleted

  • Deep Neuromuscular Block With Low Pressure Pneumoperitoneum in Laparoscopic Abdominal Surgeries

    NCT06242262 · start 2023-10-03

    Registered record
    Registry ID
    NCT06242262
    Conditions
    Deep Neuromuscular Block; Low Pressure; Pneumoperitoneum; Laparoscopic Abdominal Surgeries
    Interventions
    Deep neuromuscular block; Moderate neuromuscular block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-10-03
    Completion
    2024-03-01
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDeep Neuromuscular Block; Low Pressure; Pneumoperitoneum; Laparoscopic Abdominal Surgeries
    InterventionDeep neuromuscular block; Moderate neuromuscular block
    PhaseNot applicable
    Registry statusCompleted

  • Opioid-sparing Versus Sevoflurane Anesthesia on Early Postoperative Hypoventilation in Laparoscopic Bariatric Surgery

    NCT05962671 · start 2023-08-10

    Registered record
    Registry ID
    NCT05962671
    Conditions
    Anesthesia; Hypoventilation; Opioid Use; Bariatric Surgery
    Interventions
    Opioid-sparing based anesthesia; Sevoflurane-based anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2023-08-10
    Completion
    2024-03-30
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia; Hypoventilation; Opioid Use; Bariatric Surgery
    InterventionOpioid-sparing based anesthesia; Sevoflurane-based anesthesia
    PhasePhase 4
    Registry statusUnknown

  • Effect of MgSO4 Pretreatment on Muscle Relaxation

    NCT05757999 · start 2023-07-23

    Registered record
    Registry ID
    NCT05757999
    Conditions
    Muscle Relaxation
    Interventions
    Magnesium Sulphate; Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2023-07-23
    Completion
    2025-05
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMuscle Relaxation
    InterventionMagnesium Sulphate; Saline
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Efficacy of Magnesium Sulfate as an Adjuvant in Erector Spinae Plane Block as an Anesthetic Post Operative After Modified Radical Mastectomy

    NCT05976464 · start 2023-07-21

    Registered record
    Registry ID
    NCT05976464
    Conditions
    ESPB, Mg Sulfate,Post Mastectomy
    Interventions
    Magnesium sulfate in erector spinae plane block
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2023-07-21
    Completion
    2025-08-25
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionESPB, Mg Sulfate,Post Mastectomy
    InterventionMagnesium sulfate in erector spinae plane block
    PhaseEarly phase 1
    Registry statusCompleted

  • Continuous Spinal Anesthesia Versus General Anesthesia in Sepsis

    NCT05897151 · start 2023-06-10

    Registered record
    Registry ID
    NCT05897151
    Conditions
    Sepsis; Continuous Spinal Anesthesia; General Anesthesia
    Interventions
    Continuous spinal anesthesia; General anesthesia
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2023-06-10
    Completion
    2023-11-30
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis; Continuous Spinal Anesthesia; General Anesthesia
    InterventionContinuous spinal anesthesia; General anesthesia
    PhasePhase 4
    Registry statusUnknown

  • Direct Versus US Guided PECS Block on Controlling Postmastectomy Pain

    NCT05825430 · start 2023-04-15

    Registered record
    Registry ID
    NCT05825430
    Conditions
    Postmastectomy Pain
    Interventions
    Direct pecs block; Ultrasound guided pecs block; general anaesthetic technique only
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-04-15
    Completion
    2023-06-15
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostmastectomy Pain
    InterventionDirect pecs block; Ultrasound guided pecs block; general anaesthetic technique only
    PhaseNot applicable
    Registry statusCompleted

  • Atracurium Versus Atracurium and Magnesium Sulphate As Adjuvants to Local Anesthetic

    NCT06600945 · start 2023-02-01

    Registered record
    Registry ID
    NCT06600945
    Conditions
    Peribulbar Anesthesia
    Interventions
    Cataract surgery
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2023-02-01
    Completion
    2025-04-01
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeribulbar Anesthesia
    InterventionCataract surgery
    PhaseNot recorded
    Registry statusRecruiting