Atracurium Besylate
FDA-approved product (injectable, injection), marketed as Atracurium Besylate, Atracurium Besylate Preservative Free, Tracrium and 1 more.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Neuromuscular Blockade
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Other quaternary ammonium compounds
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA50.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli41.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae22.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Atracurium Besylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Quadratus Lumborum Versus Transversus Abdominis Plane Block Versus Caudal Block for Postoperative Analgesia After Pediatric Inguinal Hernia : Double-Blinded Randomized Trial
NCT05442905 · start 2022-08-01
Registered record
- Registry ID
- NCT05442905
- Conditions
- Quadratus Lumborum Block; Transversus Abdominis Plane Block; Caudal Block; Postoperative Pain; Inguinal Hernia
- Interventions
- propofol; Atracurium Besylate; sevoflurane
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2022-08-01
- Completion
- 2023-03-01
- Enrolment
- 60
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionQuadratus Lumborum Block; Transversus Abdominis Plane Block; Caudal Block; Postoperative Pain +1 moreInterventionpropofol; Atracurium Besylate; sevofluranePhaseNot applicableRegistry statusUnknownDexamethasone As Adjuvant for Pre - emptiveTransversusAbdominus Muscle Plane Block
NCT06970548 · start 2022-06-01
Registered record
- Registry ID
- NCT06970548
- Conditions
- Post Operative Pain
- Interventions
- Levobupivacaine
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2022-06-01
- Completion
- 2023-06-01
- Enrolment
- 40
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPost Operative PainInterventionLevobupivacainePhaseNot applicableRegistry statusCompletedComparison of Esketamine-Propofol and Fentanyl-Propofol
NCT05752409 · start 2021-10-08
Registered record
- Registry ID
- NCT05752409
- Conditions
- Hemodynamics
- Interventions
- The median dose of esketamine; The high dose of esketamine; Propofol
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2021-10-08
- Completion
- 2023-12-31
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHemodynamicsInterventionThe median dose of esketamine; The high dose of esketamine; PropofolPhaseNot applicableRegistry statusUnknownAwareness in Old Aged Patients During Laryngoscopy and Intubation Using Isolated Forearm Technique
NCT05019560 · start 2021-09-05
Registered record
- Registry ID
- NCT05019560
- Conditions
- Awareness, Anesthesia; Recall Phenomenon; Inhalation; Gas
- Interventions
- Sevoflurane; TIVA
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2021-09-05
- Completion
- 2021-11-15
- Enrolment
- 50
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAwareness, Anesthesia; Recall Phenomenon; Inhalation; GasInterventionSevoflurane; TIVAPhasePhase 4Registry statusCompletedComparison Between a Two Person Insertion With Lateral Rotation Technique of LMA and the Classic Technique
NCT05084612 · start 2021-08-02
Registered record
- Registry ID
- NCT05084612
- Conditions
- Airway Complication of Anesthesia
- Interventions
- standard LMA insertion; New technique LMA insertion
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Suspended
- Start
- 2021-08-02
- Completion
- 2025-12-25
- Enrolment
- 160
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAirway Complication of AnesthesiaInterventionstandard LMA insertion; New technique LMA insertionPhaseNot applicableRegistry statusSuspendedPain Management of Pecto-intercostal Fascial Block Versus Intravenous Fentanyl After Pediatric Cardiac Surgery
NCT04945694 · start 2021-08
Registered record
- Registry ID
- NCT04945694
- Conditions
- Pediatric Patients; Congenital Heart Surgery
- Interventions
- Ultrasound-guided bilateral pecto-intercostal fascial block; Intravenous fentanyl; Propofol; Sevoflurane; Atracurium; ultrasound
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2021-08
- Completion
- 2022-08
- Enrolment
- 80
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPediatric Patients; Congenital Heart SurgeryInterventionUltrasound-guided bilateral pecto-intercostal fascial block; Intravenous fentanyl; Propofol; Sevoflurane +2 morePhaseNot applicableRegistry statusUnknownTrial of Therapeutic Hypothermia in Patients With ARDS
NCT04545424 · start 2021-06-29
Registered record
- Registry ID
- NCT04545424
- Conditions
- Respiratory Distress Syndrome, Adult
- Interventions
- Hypothermia; Neuromuscular Blocking Agents; Standard of care
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Active not recruiting
- Start
- 2021-06-29
- Completion
- 2026-09-30
- Enrolment
- 340
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionRespiratory Distress Syndrome, AdultInterventionHypothermia; Neuromuscular Blocking Agents; Standard of carePhasePhase 2Registry statusActive not recruitingIntubation Conditions With Atracurium After Three Minutes
NCT04808440 · start 2021-03-23
Registered record
- Registry ID
- NCT04808440
- Conditions
- Obesity Female Patients Require General Anaesthesia With Intubation and Atracurium Curarization
- Interventions
- Not recorded
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Completed
- Start
- 2021-03-23
- Completion
- 2021-09-07
- Enrolment
- 100
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionObesity Female Patients Require General Anaesthesia With Intubation and Atracurium CurarizationInterventionNot recordedPhaseNot recordedRegistry statusCompletedSedation or General Anesthesia During TAVR
NCT04347603 · start 2020-12-08
Registered record
- Registry ID
- NCT04347603
- Conditions
- Stenoses, Aortic
- Interventions
- TAVR
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2020-12-08
- Completion
- 2024-03-20
- Enrolment
- 218
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionStenoses, AorticInterventionTAVRPhaseNot applicableRegistry statusCompletedConsistency Evaluation of the qCON, qNOX Indices and Bispectral Index
NCT04562181 · start 2020-09-30
Registered record
- Registry ID
- NCT04562181
- Conditions
- Anesthesia Monitor; Electroencephalography; Sleep
- Interventions
- Bispectral index and qCON/qNOX monitoring
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2020-09-30
- Completion
- 2021-11-05
- Enrolment
- 30
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAnesthesia Monitor; Electroencephalography; SleepInterventionBispectral index and qCON/qNOX monitoringPhaseNot applicableRegistry statusCompletedLow-Thoracic Epidural Anesthesia For Laparoscopic Nephrectomy.
NCT04546230 · start 2020-09-19
Registered record
- Registry ID
- NCT04546230
- Conditions
- Laparoscopic; Nephrectomy; Anesthesia; Epidural
- Interventions
- Low-Thoracic Epidural Anesthesia; General Anesthesia
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Recruiting
- Start
- 2020-09-19
- Completion
- 2026-12
- Enrolment
- 80
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLaparoscopic; Nephrectomy; Anesthesia; EpiduralInterventionLow-Thoracic Epidural Anesthesia; General AnesthesiaPhaseNot applicableRegistry statusRecruitingEffect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia
NCT05097508 · start 2020-06-20
Registered record
- Registry ID
- NCT05097508
- Conditions
- Entropy Device and How Will Muscle Relaxants Affect it
- Interventions
- Atracurium Besylate; Rocuronium Bromide; Entropy; train of four
- Study type
- INTERVENTIONAL
- Phase
- Early phase 1
- Registry status
- Completed
- Start
- 2020-06-20
- Completion
- 2021-10-01
- Enrolment
- 40
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionEntropy Device and How Will Muscle Relaxants Affect itInterventionAtracurium Besylate; Rocuronium Bromide; Entropy; train of fourPhaseEarly phase 1Registry statusCompletedCan Head Position Improve Surgical Field During Ear Surgery?
NCT04095754 · start 2020-04-12
Registered record
- Registry ID
- NCT04095754
- Conditions
- Intra-operative Bleeding
- Interventions
- Head-Up Position; Dexmedetomidine; Induction and maintenance of anaesthesia
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2020-04-12
- Completion
- 2020-10-14
- Enrolment
- 225
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionIntra-operative BleedingInterventionHead-Up Position; Dexmedetomidine; Induction and maintenance of anaesthesiaPhaseNot applicableRegistry statusCompletedComparison Between the Neuromuscular Blockade Onset Monitoring and the Expectation of a Fixed Delay After Curarization on the Quality of Laryngoscopy During Intubation in Elective Surgery (MONITURARE)
NCT03981042 · start 2019-06-14
Registered record
- Registry ID
- NCT03981042
- Conditions
- Laryngoscopy; Anesthesic Aduction; Neuromuscular Blockade; Monitoring
- Interventions
- Monitoring
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2019-06-14
- Completion
- 2019-08-02
- Enrolment
- 108
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLaryngoscopy; Anesthesic Aduction; Neuromuscular Blockade; MonitoringInterventionMonitoringPhaseNot applicableRegistry statusCompletedAnalgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block
NCT03803267 · start 2019-05-01
Registered record
- Registry ID
- NCT03803267
- Conditions
- Colorectal Cancer
- Interventions
- Erector spinae plane block; Quadratus lumborum block; Propofol; Fentanyl NCS; Atracurium Injectable Product; Endotracheal intubation; Anesthesia Maintenance; Muscle Relaxation
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2019-05-01
- Completion
- 2020-04-01
- Enrolment
- 68
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionColorectal CancerInterventionErector spinae plane block; Quadratus lumborum block; Propofol; Fentanyl NCS +4 morePhaseNot applicableRegistry statusCompleted