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AMR Drug RepurposingSmart Screeningresearch prototype

Nicardipine Hydrochloride

FDA-approved product (capsule, oral), marketed as Cardene, Cardene In 0.83% Sodium Chloride In Plastic Container, Cardene In 0.86% Sodium Chloride In Plastic Container and 7 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Nicardipine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Hypertension

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Dihydropyridine derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA54.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli44.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae7.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Nicardipine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nicardipine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage

    NCT07246629 · start 2026-09

    Registered record
    Registry ID
    NCT07246629
    Conditions
    Subarachnoid Hemorrhage
    Interventions
    Normal Saline; Nicardipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-09
    Completion
    2027-03
    Enrolment
    214

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubarachnoid Hemorrhage
    InterventionNormal Saline; Nicardipine
    PhasePhase 4
    Registry statusNot yet recruiting

  • EIT Evaluation of Different Antihypertensive Agents on the Ventilation-Perfusion Ratio in Patients With Acute Respiratory Failure

    NCT07603037 · start 2026-07-15

    Registered record
    Registry ID
    NCT07603037
    Conditions
    Acute Respiratory Failure (ARF); Hypertension; Pulmonary Perfusion Imbalance; Aortic Dissection (Subset)
    Interventions
    Nitroglycerin; Nicardipine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-07-15
    Completion
    2027-07-30
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Respiratory Failure (ARF); Hypertension; Pulmonary Perfusion Imbalance; Aortic Dissection (Subset)
    InterventionNitroglycerin; Nicardipine
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Remifentanil Monotherapy vs. Remifentanil-Nicardipine for Controlled Hypotension in Otolaryngological Surgery

    NCT07659496 · start 2026-06-30

    Registered record
    Registry ID
    NCT07659496
    Conditions
    Otolaryngological Surgery; Anesthesia
    Interventions
    Remifentanil / Nicardipine; Remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-06-30
    Completion
    2026-08-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOtolaryngological Surgery; Anesthesia
    InterventionRemifentanil / Nicardipine; Remifentanil
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Remifentanil vs. Nicardipine for Controlled Hypotension in Elective Nasal Surgery

    NCT07660562 · start 2026-06-25

    Registered record
    Registry ID
    NCT07660562
    Conditions
    Nasal Surgery; Anesthesia; Controlled Hypotension for Nasal Surgeries
    Interventions
    Nicardipine; Remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-06-25
    Completion
    2026-07-15
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNasal Surgery; Anesthesia; Controlled Hypotension for Nasal Surgeries
    InterventionNicardipine; Remifentanil
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2

    NCT07235514 · start 2026-03-24

    Registered record
    Registry ID
    NCT07235514
    Conditions
    Ischemic Stroke; Anterior Cerebral Circulation; General Anesthesia; Procedural Sedation; Thrombectomy
    Interventions
    General Anesthesia; Procedural sedation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-03-24
    Completion
    2029-06-24
    Enrolment
    958

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIschemic Stroke; Anterior Cerebral Circulation; General Anesthesia; Procedural Sedation +1 more
    InterventionGeneral Anesthesia; Procedural sedation
    PhaseNot applicable
    Registry statusRecruiting

  • Pharmacometric Modeling of a Hospital Preparation

    NCT07372560 · start 2026-03-01

    Registered record
    Registry ID
    NCT07372560
    Conditions
    Hypertensive Patients
    Interventions
    Evaluation of the pharmacokinetic parameters of an oral formulation of nicardipine hydrochloride
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2026-03-01
    Completion
    2028-06-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertensive Patients
    InterventionEvaluation of the pharmacokinetic parameters of an oral formulation of nicardipine hydrochloride
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Association of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers With Post-Stroke Pneumonia: A Real-World Retrospective Cohort Study

    NCT07262710 · start 2025-12-01

    Registered record
    Registry ID
    NCT07262710
    Conditions
    Post-stroke Pneumonia
    Interventions
    angiotensin converting enzyme inhibitors; Calcium Channel Blockers; Angiotensin Receptor Blockers
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2025-12-01
    Completion
    2026-08-19
    Enrolment
    13,656

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-stroke Pneumonia
    Interventionangiotensin converting enzyme inhibitors; Calcium Channel Blockers; Angiotensin Receptor Blockers
    PhaseNot recorded
    Registry statusNot yet recruiting

  • Prevention of Coronary Microvascular Dysfunction Post-PCI by Intracoronary Nicardipine

    NCT03184155 · start 2025-12

    Registered record
    Registry ID
    NCT03184155
    Conditions
    Coronary Artery Disease
    Interventions
    Nicardipine; Sterile Saline
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Withdrawn
    Start
    2025-12
    Completion
    2026-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease
    InterventionNicardipine; Sterile Saline
    PhaseEarly phase 1
    Registry statusWithdrawn

  • A Comparison of Nicardipine and Labetalol for Blood Pressure Control in Intensive Care Patients After Hemorrhagic Stroke Brain Surgery

    NCT07364201 · start 2025-11-14

    Registered record
    Registry ID
    NCT07364201
    Conditions
    Hemorrhagic Strokes; Postoperative Hypertension; Hemodynamic Instability
    Interventions
    Nicardipine; Labetalol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-11-14
    Completion
    2026-01-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemorrhagic Strokes; Postoperative Hypertension; Hemodynamic Instability
    InterventionNicardipine; Labetalol
    PhaseNot applicable
    Registry statusCompleted

  • NICardipine for Fast Achievement of Systolic BP Targets in ICH

    NCT07044232 · start 2025-10-01

    Registered record
    Registry ID
    NCT07044232
    Conditions
    Intracerebral Haemorrhage
    Interventions
    Nicardipine; Glyceryl trinitrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-10-01
    Completion
    2027-09-30
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Haemorrhage
    InterventionNicardipine; Glyceryl trinitrate
    PhasePhase 4
    Registry statusRecruiting

  • Hypotensive Anesthesia for Orthognathic Surgery

    NCT06093893 · start 2025-03-04

    Registered record
    Registry ID
    NCT06093893
    Conditions
    Hypotensive Anesthesia; Orthognathic Surgery
    Interventions
    Dexmedetomidine; Nicardipine; Labetalol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2025-03-04
    Completion
    2026-02-06
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypotensive Anesthesia; Orthognathic Surgery
    InterventionDexmedetomidine; Nicardipine; Labetalol
    PhasePhase 4
    Registry statusCompleted

  • Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)

    NCT06677970 · start 2024-10-01

    Registered record
    Registry ID
    NCT06677970
    Conditions
    Acute Ischemic Stroke
    Interventions
    BP lowering drugs (nicardipine, labetalol, urapidil); BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2024-10-01
    Completion
    2029-12-03
    Enrolment
    176

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Ischemic Stroke
    InterventionBP lowering drugs (nicardipine, labetalol, urapidil); BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
    PhasePhase 3
    Registry statusRecruiting

  • Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage

    NCT06402968 · start 2024-06-01

    Registered record
    Registry ID
    NCT06402968
    Conditions
    Intracerebral Hemorrhage; Stroke; Hypertension
    Interventions
    Clevidipine Injection; Alternate IV Antihypertensive Regimen
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2024-06-01
    Completion
    2028-07-30
    Enrolment
    1,018

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Hemorrhage; Stroke; Hypertension
    InterventionClevidipine Injection; Alternate IV Antihypertensive Regimen
    PhaseNot recorded
    Registry statusRecruiting

  • Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial

    NCT06329635 · start 2024-05-27

    Registered record
    Registry ID
    NCT06329635
    Conditions
    Aneurysmal Subarachnoid Hemorrhage; Vasospasm
    Interventions
    Intrathecal Nicardipine; No intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-05-27
    Completion
    2026-05
    Enrolment
    396

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAneurysmal Subarachnoid Hemorrhage; Vasospasm
    InterventionIntrathecal Nicardipine; No intervention
    PhaseNot applicable
    Registry statusRecruiting

  • The Contractile Response of the Thoracic Aorta to Vasoactive Substances

    NCT06374836 · start 2024-05-27

    Registered record
    Registry ID
    NCT06374836
    Conditions
    Human Thoracic Aorta Contractility
    Interventions
    Phenylephrine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2024-05-27
    Completion
    2024-10-31
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHuman Thoracic Aorta Contractility
    InterventionPhenylephrine
    PhaseNot recorded
    Registry statusCompleted