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AMR Drug RepurposingSmart Screeningresearch prototype

Nicardipine Hydrochloride

FDA-approved product (capsule, oral), marketed as Cardene, Cardene In 0.83% Sodium Chloride In Plastic Container, Cardene In 0.86% Sodium Chloride In Plastic Container and 7 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Nicardipine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Hypertension

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Dihydropyridine derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA54.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli44.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae7.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Nicardipine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nicardipine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of the Pharmacokinetic and Pharmacodynamic Responses in Healthy and Altered Human Cardiovascular Systems

    NCT03098680 · start 2017-04-24

    Registered record
    Registry ID
    NCT03098680
    Conditions
    Drug-Related Side Effects and Adverse Reactions; Cardiovascular System Disease
    Interventions
    Albuterol Sulfate; Nicardipine Hydrochloride; Dobutamine Hydrochloride; Phenylephrine Hydrochloride; Verapamil Hydrochloride; Phentolamine Mesylate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2017-04-24
    Completion
    2020-02-29
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug-Related Side Effects and Adverse Reactions; Cardiovascular System Disease
    InterventionAlbuterol Sulfate; Nicardipine Hydrochloride; Dobutamine Hydrochloride; Phenylephrine Hydrochloride +3 more
    PhasePhase 1
    Registry statusTerminated

  • The Intra-arterial Vasospasm Trial

    NCT01996436 · start 2016-08-29

    Registered record
    Registry ID
    NCT01996436
    Conditions
    Cerebral Vasospasm
    Interventions
    Nicardipine; Verapamil; Nicardipine + Verapamil + Nitroglycerin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2016-08-29
    Completion
    2024-08-12
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCerebral Vasospasm
    InterventionNicardipine; Verapamil; Nicardipine + Verapamil + Nitroglycerin
    PhasePhase 4
    Registry statusTerminated

  • The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine

    NCT02558023 · start 2015-09

    Registered record
    Registry ID
    NCT02558023
    Conditions
    Hypertension; Preeclampsia
    Interventions
    Urapidil; Nicardipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-09
    Completion
    2020-08
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Preeclampsia
    InterventionUrapidil; Nicardipine
    PhasePhase 3
    Registry statusTerminated

  • Pupillary Reflex Measurement to Guide Intraoperative Analgesia During Laparoscopic Surgery

    NCT02116868 · start 2014-03

    Registered record
    Registry ID
    NCT02116868
    Conditions
    Scheduled Laparoscopic Surgery
    Interventions
    Pupillometry guided analgesia (PP); Tailored remifentanil controlled infusion; Tailored antihypertensive drug administration
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-03
    Completion
    2018-04
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScheduled Laparoscopic Surgery
    InterventionPupillometry guided analgesia (PP); Tailored remifentanil controlled infusion; Tailored antihypertensive drug administration
    PhaseNot applicable
    Registry statusCompleted

  • Nicardipine vs Esmolol Craniotomy Emergence

    NCT01951950 · start 2013-09

    Registered record
    Registry ID
    NCT01951950
    Conditions
    Brain Tumors
    Interventions
    Nicardipine; Esmolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-09
    Completion
    2014-05
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBrain Tumors
    InterventionNicardipine; Esmolol
    PhasePhase 1
    Registry statusCompleted

  • The Effect of Deliberate Hypotension on QTc, Tp-e Intervals and Heart Rate Variability

    NCT01634594 · start 2012-06

    Registered record
    Registry ID
    NCT01634594
    Conditions
    Mandibular Prognathism; Mandibular Retrognathism
    Interventions
    Group R; Group N; Group D
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-06
    Completion
    2013-02
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMandibular Prognathism; Mandibular Retrognathism
    InterventionGroup R; Group N; Group D
    PhasePhase 4
    Registry statusCompleted

  • Effect of Nicardipine on Renal Function in Deliberate Hypotension

    NCT02271191 · start 2012-05

    Registered record
    Registry ID
    NCT02271191
    Conditions
    Spinal Stenosis
    Interventions
    Nicardipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-05
    Completion
    2013-01
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinal Stenosis
    InterventionNicardipine
    PhasePhase 4
    Registry statusCompleted

  • Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)

    NCT01422616 · start 2012-03

    Registered record
    Registry ID
    NCT01422616
    Conditions
    Ischemic Stroke; High Blood Pressure
    Interventions
    Low-dose rtPA; Standard-dose rtPA; Intensive blood pressure (BP) lowering; BP management policies
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-03
    Completion
    2018-08
    Enrolment
    4,587

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIschemic Stroke; High Blood Pressure
    InterventionLow-dose rtPA; Standard-dose rtPA; Intensive blood pressure (BP) lowering; BP management policies
    PhasePhase 3
    Registry statusCompleted

  • Antihypertensive Treatment of Acute Cerebral Hemorrhage-II

    NCT01176565 · start 2011-05-15

    Registered record
    Registry ID
    NCT01176565
    Conditions
    Intracerebral Hemorrhage
    Interventions
    Intravenous nicardipine hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2011-05-15
    Completion
    2016-03-08
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Hemorrhage
    InterventionIntravenous nicardipine hydrochloride
    PhasePhase 3
    Registry statusTerminated

  • Comparison of Intravenous Injection of Calcium Antagonist and Beta-blockade on Endothelial Shear Stress of Coronary Artery

    NCT01171911 · start 2010-10

    Registered record
    Registry ID
    NCT01171911
    Conditions
    Acute Coronary Syndrome; Coronary Artery Disease
    Interventions
    Nicardipine , Esmolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2010-10
    Completion
    2010-12
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome; Coronary Artery Disease
    InterventionNicardipine , Esmolol
    PhasePhase 4
    Registry statusUnknown

  • The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia

    NCT01175746 · start 2010-08

    Registered record
    Registry ID
    NCT01175746
    Conditions
    Healthy Subjects
    Interventions
    Nicardipine; remifentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-08
    Completion
    2011-12
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Subjects
    InterventionNicardipine; remifentanil
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery

    NCT00848991 · start 2009-02

    Registered record
    Registry ID
    NCT00848991
    Conditions
    Cranitomy Surgery
    Interventions
    Precedex; Propofol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-02
    Completion
    2010-02
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCranitomy Surgery
    InterventionPrecedex; Propofol
    PhasePhase 3
    Registry statusCompleted

  • Clevidipine in the Treatment of Blood Pressure in Patients With Acute Heart Failure (PRONTO)

    NCT00803634 · start 2008-12

    Registered record
    Registry ID
    NCT00803634
    Conditions
    Hypertension; Heart Failure
    Interventions
    Clevidipine; Standard of Care IV antihypertensive
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-12
    Completion
    2012-03
    Enrolment
    117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Heart Failure
    InterventionClevidipine; Standard of Care IV antihypertensive
    PhasePhase 3
    Registry statusCompleted

  • Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department

    NCT00765648 · start 2008-10

    Registered record
    Registry ID
    NCT00765648
    Conditions
    Hypertensive Urgency
    Interventions
    nicardipine intravenous; Labetalol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-10
    Completion
    2010-01
    Enrolment
    226

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertensive Urgency
    Interventionnicardipine intravenous; Labetalol
    PhasePhase 4
    Registry statusCompleted

  • The Second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial

    NCT00716079 · start 2008-09

    Registered record
    Registry ID
    NCT00716079
    Conditions
    Intracerebral Hemorrhage; Stroke; Hypertension
    Interventions
    Blood pressure management policies
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-09
    Completion
    2012-12
    Enrolment
    2,839

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Hemorrhage; Stroke; Hypertension
    InterventionBlood pressure management policies
    PhaseNot applicable
    Registry statusCompleted