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AMR Drug RepurposingSmart Screeningresearch prototype

Nicardipine Hydrochloride

FDA-approved product (capsule, oral), marketed as Cardene, Cardene In 0.83% Sodium Chloride In Plastic Container, Cardene In 0.86% Sodium Chloride In Plastic Container and 7 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Nicardipine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Hypertension

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Dihydropyridine derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA54.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli44.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae7.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Nicardipine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nicardipine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Impact of Antihypertensive Therapy on Recurrence Risk of Ovarian Cancer for Bevacizumab-associated Hypertension

    NCT06515678 · start 2024-05-20

    Registered record
    Registry ID
    NCT06515678
    Conditions
    Ovarian Cancer; Antiangiogenic-Associated Hypertension; Adjuvant Bevacizumab; Hypertension
    Interventions
    arm A - angiotensin converting enzyme inhibitors (ACEi); arm B - calcium channel blockers (CCBs); arm R - angiotensin receptor blockers ARB
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2024-05-20
    Completion
    2024-08-31
    Enrolment
    9,464

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Cancer; Antiangiogenic-Associated Hypertension; Adjuvant Bevacizumab; Hypertension
    Interventionarm A - angiotensin converting enzyme inhibitors (ACEi); arm B - calcium channel blockers (CCBs); arm R - angiotensin receptor blockers ARB
    PhaseNot recorded
    Registry statusUnknown

  • Effects of Subcutaneously Infiltrated Nicardipine on the Success Rate of Radial Artety Cannulation

    NCT05920538 · start 2023-03-13

    Registered record
    Registry ID
    NCT05920538
    Conditions
    Radial Artery Cannulation
    Interventions
    Nicardipine; Normal saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-03-13
    Completion
    2024-01
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRadial Artery Cannulation
    InterventionNicardipine; Normal saline
    PhaseNot applicable
    Registry statusUnknown

  • Dilution of Verapamil During Intraarterial Administration

    NCT05625503 · start 2022-12-13

    Registered record
    Registry ID
    NCT05625503
    Conditions
    Vasospasm; Peripheral; Burning; Pain
    Interventions
    Verapamil; Nicardipine
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2022-12-13
    Completion
    2023-12-01
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVasospasm; Peripheral; Burning; Pain
    InterventionVerapamil; Nicardipine
    PhaseEarly phase 1
    Registry statusCompleted

  • The Effects of Nicardipine and Esmolol Applied for Controlled Hypotension

    NCT05430724 · start 2022-05-12

    Registered record
    Registry ID
    NCT05430724
    Conditions
    Hypotension; Surgery-Complications; Oxygen Deficiency
    Interventions
    Controlled hypotention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-05-12
    Completion
    2022-08-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypotension; Surgery-Complications; Oxygen Deficiency
    InterventionControlled hypotention
    PhaseNot applicable
    Registry statusCompleted

  • Relationship Between Perioperative Carotid Blood Flow Monitoring and Cerebral Function Protection in Cardiac Surgery

    NCT05586347 · start 2022-04-22

    Registered record
    Registry ID
    NCT05586347
    Conditions
    Coronary Artery Bypass Grafting; Cardiopulmonary Bypass
    Interventions
    Nicardipine; normal saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-04-22
    Completion
    2022-09-30
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Bypass Grafting; Cardiopulmonary Bypass
    InterventionNicardipine; normal saline
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Individualized Versus Standard Bp Management During MT for Anterior Ischemic Stroke

    NCT04352296 · start 2021-03-08

    Registered record
    Registry ID
    NCT04352296
    Conditions
    Acute Cerebrovascular Accident
    Interventions
    Individualized blood pressure; Standard blood pressure
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-03-08
    Completion
    2024-01-16
    Enrolment
    433

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Cerebrovascular Accident
    InterventionIndividualized blood pressure; Standard blood pressure
    PhaseNot applicable
    Registry statusCompleted

  • Nicardipine to Avoid Spasm in Trans Radial Percutaneous Coronary Intervention

    NCT04538534 · start 2020-11-01

    Registered record
    Registry ID
    NCT04538534
    Conditions
    Spasm Artery
    Interventions
    Nicardipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2020-11-01
    Completion
    2022-02-01
    Enrolment
    1,500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpasm Artery
    InterventionNicardipine
    PhasePhase 3
    Registry statusCompleted

  • A Safety and Efficacy Study of NicaPlant® in Aneurysmal Subarachnoid Haemorrhage Patients Undergoing Aneurysm Clipping

    NCT04269408 · start 2020-04-05

    Registered record
    Registry ID
    NCT04269408
    Conditions
    Aneurysmal Subarachnoid Hemorrhage
    Interventions
    Nicardipine; Standard of care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2020-04-05
    Completion
    2023-01-23
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAneurysmal Subarachnoid Hemorrhage
    InterventionNicardipine; Standard of care
    PhasePhase 2
    Registry statusCompleted

  • Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    NCT04278404 · start 2020-03-05

    Registered record
    Registry ID
    NCT04278404
    Conditions
    Coronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension; Pain; Hyperphosphatemia; Primary Hyperaldosteronism; Edema; Hypokalemia; Heart Failure; Hemophilia; Menorrhagia; Insomnia; Pneumonia; Skin Infection; Arrythmia; Asthma in Children; Bronchopulmonary Dysplasia; Adrenal Insufficiency; Fibrinolysis; Hemorrhage; Attention Deficit Hyperactivity Disorder; Multisystem Inflammatory Syndrome in Children (MIS-C); Kawasaki Disease; Coagulation Disorder; Down Syndrome
    Interventions
    The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2020-03-05
    Completion
    2026-12
    Enrolment
    5,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension +22 more
    InterventionThe POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
    PhaseNot recorded
    Registry statusRecruiting

  • Effect of Anesthetic Conditions on Stapling Thickness and Quality

    NCT04191564 · start 2020-03

    Registered record
    Registry ID
    NCT04191564
    Conditions
    Gastrectomy
    Interventions
    low perfusion state; normal perfusion state
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-03
    Completion
    2021-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastrectomy
    Interventionlow perfusion state; normal perfusion state
    PhaseNot applicable
    Registry statusUnknown

  • Blood Pressure After Endovascular Stroke Therapy-II

    NCT04116112 · start 2020-01-17

    Registered record
    Registry ID
    NCT04116112
    Conditions
    Acute Stroke; Endovascular Thrombectomy
    Interventions
    Nicardipine; Labetalol; Hydralazine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2020-01-17
    Completion
    2022-12-15
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Stroke; Endovascular Thrombectomy
    InterventionNicardipine; Labetalol; Hydralazine
    PhasePhase 2
    Registry statusCompleted

  • Nicardipine and Labetalol Effects on Cerebral Hemodynamics in Preeclampsia

    NCT03761888 · start 2018-11-29

    Registered record
    Registry ID
    NCT03761888
    Conditions
    Preeclampsia Severe
    Interventions
    optic nerve sheath measurement and transcranial doppler
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2018-11-29
    Completion
    2019-05
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreeclampsia Severe
    Interventionoptic nerve sheath measurement and transcranial doppler
    PhaseNot recorded
    Registry statusUnknown

  • Intraarterial Nitroglycerin Versus Nicardipine and Radial Artery Occlusion

    NCT03622060 · start 2018-06-04

    Registered record
    Registry ID
    NCT03622060
    Conditions
    Radial Artery Injury at Wrist and Hand Level; Occlusion of Artery; Vasodilation
    Interventions
    Nitroglycerin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-06-04
    Completion
    2019-05-22
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRadial Artery Injury at Wrist and Hand Level; Occlusion of Artery; Vasodilation
    InterventionNitroglycerin
    PhasePhase 3
    Registry statusCompleted

  • Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries

    NCT03497351 · start 2018-04-15

    Registered record
    Registry ID
    NCT03497351
    Conditions
    General Surgery
    Interventions
    Nicardipine; Urapidil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-04-15
    Completion
    2019-02-15
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneral Surgery
    InterventionNicardipine; Urapidil
    PhaseNot applicable
    Registry statusCompleted

  • Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment

    NCT03207100 · start 2017-12-06

    Registered record
    Registry ID
    NCT03207100
    Conditions
    Early Systolic Blood Pressure Control Rate; Hematoma Growth; Blood Pressure Variability; Healthcare Worker Satisfaction; Duration of ICU Treatment and Mechanical Ventilation
    Interventions
    Analgesia-first minimal sedation; Antihypertensive treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-12-06
    Completion
    2021-05-15
    Enrolment
    338

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEarly Systolic Blood Pressure Control Rate; Hematoma Growth; Blood Pressure Variability; Healthcare Worker Satisfaction +1 more
    InterventionAnalgesia-first minimal sedation; Antihypertensive treatment
    PhaseNot applicable
    Registry statusCompleted