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AMR Drug RepurposingSmart Screeningresearch prototype

Sotalol Hydrochloride

FDA-approved product (tablet, oral), marketed as Betapace, Betapace Af, Sorine and 2 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Sotalol Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Ventricular arrhythmia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta blocking agents, non-selective
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA22.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli26.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae24.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sotalol Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sotalol Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Pulmonary Vein Isolation With Versus Without Continued Antiarrhythmic Drug Treatment in Subjects With Recurrent Atrial Fibrillation

    NCT02475642 · start 2014-03

    Registered record
    Registry ID
    NCT02475642
    Conditions
    Atrial Fibrillation
    Interventions
    PVI-ADT; PVI+ADT
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-03
    Completion
    2016-08
    Enrolment
    152

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionPVI-ADT; PVI+ADT
    PhasePhase 4
    Registry statusUnknown

  • Using an iPhone ECG to Monitor the QT Interval on Dofetilide and Sotalol Patients

    NCT02241252 · start 2013-09

    Registered record
    Registry ID
    NCT02241252
    Conditions
    Cardiac Arrhythmia; Qt Interval, Variation in
    Interventions
    iPhone ECG
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-09
    Completion
    2015-05
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiac Arrhythmia; Qt Interval, Variation in
    InterventioniPhone ECG
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Reverse Remodeling and PVI Versus CFAE and/or Linear Lesions and PVI for Persistent AF

    NCT01877473 · start 2013-05

    Registered record
    Registry ID
    NCT01877473
    Conditions
    Persistent Atrial Fibrillation
    Interventions
    Ablation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2013-05
    Completion
    2013-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPersistent Atrial Fibrillation
    InterventionAblation
    PhasePhase 4
    Registry statusWithdrawn

  • Effectiveness Study of Atrial Fibrillation

    NCT01856075 · start 2012-10

    Registered record
    Registry ID
    NCT01856075
    Conditions
    Atrial Fibrillation
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-10
    Completion
    2015-08
    Enrolment
    1,015

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Catheter Ablation for Recently Diagnosed Paroxysmal Atrial Fibrillation

    NCT01505296 · start 2011-12

    Registered record
    Registry ID
    NCT01505296
    Conditions
    Atrial Fibrillation
    Interventions
    Antiarrhythmic drug; Catheter ablation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2011-12
    Completion
    2014-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAntiarrhythmic drug; Catheter ablation
    PhasePhase 4
    Registry statusWithdrawn

  • Kansai Plus Atrial Fibrillation Trial

    NCT01477983 · start 2011-11

    Registered record
    Registry ID
    NCT01477983
    Conditions
    Atrial Fibrillation
    Interventions
    ATP guide additional ablation.; Antiarrhythmic drug (AAD); ATP guide additional ablation.; Control; Control; Antiarrhythmic drug (AAD); Control; Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-11
    Completion
    2017-07
    Enrolment
    2,113

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionATP guide additional ablation.; Antiarrhythmic drug (AAD); ATP guide additional ablation.; Control +4 more
    PhasePhase 4
    Registry statusCompleted

  • Catheter Ablation Compared With Pharmacological Therapy for Atrial Fibrillation (CAPTAF Trial)

    NCT02294955 · start 2008-05

    Registered record
    Registry ID
    NCT02294955
    Conditions
    Atrial Fibrillation; Quality of Life
    Interventions
    Catheterablation; Amiodarone; Sotalol; Flecainide; Propafenone; Disopyramide; Dronedarone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2008-05
    Completion
    2018-09
    Enrolment
    152

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Quality of Life
    InterventionCatheterablation; Amiodarone; Sotalol; Flecainide +3 more
    PhaseNot applicable
    Registry statusUnknown

  • Genetic Sources of Variability of the Adaptation of the Ventricular Repolarisation

    NCT00773201 · start 2008-02

    Registered record
    Registry ID
    NCT00773201
    Conditions
    Healthy Volunteers
    Interventions
    Sotalol 80 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-02
    Completion
    2012-03
    Enrolment
    997

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionSotalol 80 mg
    PhasePhase 1
    Registry statusCompleted

  • AV Node Ablation and Pacemaker Therapy Compared to Drug Therapy for Atrial Fibrillation - Pilot Study

    NCT00589303 · start 2007-12

    Registered record
    Registry ID
    NCT00589303
    Conditions
    Atrial Fibrillation; Heart Failure
    Interventions
    FDA approved rate and rhythm control drugs; AV Node ablation and device implant
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2007-12
    Completion
    2011-07
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Heart Failure
    InterventionFDA approved rate and rhythm control drugs; AV Node ablation and device implant
    PhasePhase 3
    Registry statusTerminated

  • A Comparison of the Drug Therapy Versus Re-Ablation

    NCT01709682 · start 2007-11

    Registered record
    Registry ID
    NCT01709682
    Conditions
    Paroxysmal Atrial Fibrillation; Failed First Radiofrequency Ablation Procedure
    Interventions
    Anti-Arrhythmia Agents (propafenone, flecainide, and/or sotalol, or amiodarone); re-ablation procedure; ILR implantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-11
    Completion
    2012-08
    Enrolment
    154

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParoxysmal Atrial Fibrillation; Failed First Radiofrequency Ablation Procedure
    InterventionAnti-Arrhythmia Agents (propafenone, flecainide, and/or sotalol, or amiodarone); re-ablation procedure; ILR implantation
    PhasePhase 2
    Registry statusCompleted

  • A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation

    NCT00523978 · start 2006-10

    Registered record
    Registry ID
    NCT00523978
    Conditions
    Paroxysmal Atrial Fibrillation
    Interventions
    Arctic Front® Cryoablation Catheter; Flecainide or Sotalol or Propafenone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-10
    Completion
    2011-07
    Enrolment
    245

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParoxysmal Atrial Fibrillation
    InterventionArctic Front® Cryoablation Catheter; Flecainide or Sotalol or Propafenone
    PhasePhase 3
    Registry statusCompleted

  • Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial

    NCT00578617 · start 2006-09

    Registered record
    Registry ID
    NCT00578617
    Conditions
    Atrial Fibrillation; Arrhythmia
    Interventions
    Rate Control; Ablation Therapy; Rate Control; Rate control; Rate control; Rate control; Rate Control; Rate Control; Rate Control; Rhythm Control; Rhythm control; Rhythm control; Rhythm control; Rhythm control; Rhythm control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-09
    Completion
    2010-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Arrhythmia
    InterventionRate Control; Ablation Therapy; Rate Control; Rate control +11 more
    PhaseNot applicable
    Registry statusCompleted

  • High Intensity Focused Ultrasound (HIFU) Ablation System Study

    NCT00392106 · start 2006-04

    Registered record
    Registry ID
    NCT00392106
    Conditions
    Atrial Fibrillation
    Interventions
    propafenone; flecainide; dofetilide; sotolol; Pulmonary vein ablation; Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Suspended
    Start
    2006-04
    Completion
    2011-06
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    Interventionpropafenone; flecainide; dofetilide; sotolol +2 more
    PhasePhase 3
    Registry statusSuspended

  • Catheter Ablation Versus Medical Treatment of AF in Heart Failure

    NCT01411371 · start 2005-03

    Registered record
    Registry ID
    NCT01411371
    Conditions
    Atrial Fibrillation; Heart Failure
    Interventions
    Catheter ablation of persistent atrial fibrillation; Medical treatment alone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-03
    Completion
    2013-02
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Heart Failure
    InterventionCatheter ablation of persistent atrial fibrillation; Medical treatment alone
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Safety Evaluation of Azimilide or Sotalol vs Placebo for Treatment of Patients With Atrial Fibrillation.

    NCT00035451 · start 2001-02

    Registered record
    Registry ID
    NCT00035451
    Conditions
    Atrial Fibrillation
    Interventions
    Azimilide Dihydrochloride; Placebo; Sotalol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2001-02
    Completion
    2003-06
    Enrolment
    658

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAzimilide Dihydrochloride; Placebo; Sotalol
    PhasePhase 3
    Registry statusCompleted