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AMR Drug RepurposingSmart Screeningresearch prototype

Sotalol Hydrochloride

FDA-approved product (tablet, oral), marketed as Betapace, Betapace Af, Sorine and 2 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Sotalol Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Ventricular arrhythmia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta blocking agents, non-selective
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA22.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli26.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae24.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sotalol Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sotalol Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Beta Blockers Plus Intravenous Flecainide for Paroxysmal Atrial Fibrillation: a Real-world Chios Registry (BETAFLEC-CHIOS)

    NCT04991896 · start 2020-01-01

    Registered record
    Registry ID
    NCT04991896
    Conditions
    Atrial Fibrillation; Arrhythmias, Cardiac
    Interventions
    Flecainide Injectable Product
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-01-01
    Completion
    2021-06-30
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Arrhythmias, Cardiac
    InterventionFlecainide Injectable Product
    PhaseNot recorded
    Registry statusCompleted

  • Continuation of Antiarrhythmics Following Ventricular Tachycardia Catheter Ablation

    NCT04208997 · start 2019-12-19

    Registered record
    Registry ID
    NCT04208997
    Conditions
    Tachycardia, Ventricular; Catheter Ablation
    Interventions
    Antiarrhythmic drug
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2019-12-19
    Completion
    2021-06-30
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTachycardia, Ventricular; Catheter Ablation
    InterventionAntiarrhythmic drug
    PhasePhase 3
    Registry statusTerminated

  • Efficacy and Safety of Sotalol in Children With Arrhythmia

    NCT03895411 · start 2019-08

    Registered record
    Registry ID
    NCT03895411
    Conditions
    Arrhythmia
    Interventions
    sotalol; Propafenone; betaloc
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-08
    Completion
    2022-12
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrhythmia
    Interventionsotalol; Propafenone; betaloc
    PhasePhase 4
    Registry statusUnknown

  • Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients

    NCT04128878 · start 2019-05-01

    Registered record
    Registry ID
    NCT04128878
    Conditions
    Atrial Fibrillation
    Interventions
    Sotalol; Dofetilide
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2019-05-01
    Completion
    2020-12-31
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionSotalol; Dofetilide
    PhaseNot recorded
    Registry statusCompleted

  • Bioequivalence Study of Sotalol, Tablets, 160 mg (Pharmtechnology LLC, Belarus), and Sotalex ®, Tablets, 160 mg (Bristol-Myers Squibb GmbH & Co. KGaA, Germany), in Healthy Volunteers Under Fasting Conditions

    NCT03799536 · start 2019-01-09

    Registered record
    Registry ID
    NCT03799536
    Conditions
    Bioequivalence
    Interventions
    Sotalol; Sotalex
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-01-09
    Completion
    2019-02-11
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBioequivalence
    InterventionSotalol; Sotalex
    PhasePhase 1
    Registry statusCompleted

  • Prospective Assessment of Premature Ventricular Contractions Suppression in Cardiomyopathy(PAPS)

    NCT03228823 · start 2018-08-01

    Registered record
    Registry ID
    NCT03228823
    Conditions
    Ventricular Premature Beats, Contractions, or Systoles; Cardiomyopathies
    Interventions
    Radiofrequency ablation; Amiodarone (Antiarrhythmic drug)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-08-01
    Completion
    2021-08-31
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentricular Premature Beats, Contractions, or Systoles; Cardiomyopathies
    InterventionRadiofrequency ablation; Amiodarone (Antiarrhythmic drug)
    PhasePhase 4
    Registry statusUnknown

  • Initial Management of Patients Receiving a Single Shock (IMPRESS)

    NCT03531502 · start 2018-04-09

    Registered record
    Registry ID
    NCT03531502
    Conditions
    Ventricular Tachycardia
    Interventions
    Ventricular Tachycardia Ablation; Standard Medical Therapy; Non-Invasive Programmed Stimulation (NIPS)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2018-04-09
    Completion
    2023-04-04
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentricular Tachycardia
    InterventionVentricular Tachycardia Ablation; Standard Medical Therapy; Non-Invasive Programmed Stimulation (NIPS)
    PhaseNot applicable
    Registry statusTerminated

  • The Impact of "First-Line" Rhythm Therapy on AF Progression

    NCT05514860 · start 2017-01

    Registered record
    Registry ID
    NCT05514860
    Conditions
    Atrial Fibrillation
    Interventions
    Cryoballoon-based PVI; Anti-Arrhythmic Drug Therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-01
    Completion
    2022-11
    Enrolment
    303

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionCryoballoon-based PVI; Anti-Arrhythmic Drug Therapy
    PhaseNot applicable
    Registry statusUnknown

  • Antiarrhythmics or Ablation for Ventricular Tachycardia 2

    NCT02830360 · start 2016-10

    Registered record
    Registry ID
    NCT02830360
    Conditions
    Ventricular Tachycardia (VT)
    Interventions
    Antiarrythmic Drug Therapy; Catheter ablation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-10
    Completion
    2024-06-30
    Enrolment
    416

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentricular Tachycardia (VT)
    InterventionAntiarrythmic Drug Therapy; Catheter ablation
    PhasePhase 4
    Registry statusCompleted

  • Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)

    NCT02624765 · start 2016-02

    Registered record
    Registry ID
    NCT02624765
    Conditions
    Fetal Atrial Flutter Without Hydrops; Fetal Supraventricular Tachycardia Without Hydrops; Fetal Supraventricular Tachycardia With Hydrops
    Interventions
    Digoxin (monotherapy); Sotalol (monotherapy); Flecainide (monotherapy); Digoxin (dual therapy); Sotalol (dual therapy); Flecainide (dual therapy)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-02
    Completion
    2024-03-31
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFetal Atrial Flutter Without Hydrops; Fetal Supraventricular Tachycardia Without Hydrops; Fetal Supraventricular Tachycardia With Hydrops
    InterventionDigoxin (monotherapy); Sotalol (monotherapy); Flecainide (monotherapy); Digoxin (dual therapy) +2 more
    PhasePhase 3
    Registry statusCompleted

  • Ablation Verses Anti-arrhythmic Therapy for Reducing All Hospital Episodes From Recurrent Atrial Fibrillation

    NCT02459574 · start 2015-05-01

    Registered record
    Registry ID
    NCT02459574
    Conditions
    Heart Failure; Recurrent Atrial Fibrillation
    Interventions
    AVATAR-AF ablation; Anti-Arrhythmic therapy; Conventional AF ablation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-05-01
    Completion
    2018-11-27
    Enrolment
    321

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure; Recurrent Atrial Fibrillation
    InterventionAVATAR-AF ablation; Anti-Arrhythmic therapy; Conventional AF ablation
    PhaseNot applicable
    Registry statusCompleted

  • Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Ischemic Ventricular Tachyarrhythmias

    NCT02303639 · start 2015-04

    Registered record
    Registry ID
    NCT02303639
    Conditions
    Myocardial Infarction; Ventricular Tachyarrhythmia
    Interventions
    Radiofrequency catheter ablation; Antiarrhythmic drug therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-04
    Completion
    2018-06
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Infarction; Ventricular Tachyarrhythmia
    InterventionRadiofrequency catheter ablation; Antiarrhythmic drug therapy
    PhasePhase 4
    Registry statusUnknown

  • Study of the Effects of BMS-919373 on the Electrical Activity of the Heart Using Pacemakers

    NCT02153437 · start 2014-10-30

    Registered record
    Registry ID
    NCT02153437
    Conditions
    Atrial Fibrillation
    Interventions
    BMS-919373; Sotalol; Placebo for BMS-919373
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2014-10-30
    Completion
    2016-10-20
    Enrolment
    7

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionBMS-919373; Sotalol; Placebo for BMS-919373
    PhasePhase 1
    Registry statusTerminated

  • Anti-arrhythmic Therapy vs Catheter Ablation as First Line Treatment for AICD Shock Prevention

    NCT02114528 · start 2014-10

    Registered record
    Registry ID
    NCT02114528
    Conditions
    Ventricular Tachycardia; Ventricular Arrhythmia
    Interventions
    Antiarrhythmic Drug Therapy; Catheter ablation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2014-10
    Completion
    2015-11
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentricular Tachycardia; Ventricular Arrhythmia
    InterventionAntiarrhythmic Drug Therapy; Catheter ablation
    PhasePhase 4
    Registry statusTerminated

  • Using Smart Phone Technology in Detecting the Presence of Atrial Fibrillation

    NCT02214069 · start 2014-08

    Registered record
    Registry ID
    NCT02214069
    Conditions
    Atrial Fibrillation; Atrial Flutter
    Interventions
    Record and transmit heart rhythm
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-08
    Completion
    2017-07
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Atrial Flutter
    InterventionRecord and transmit heart rhythm
    PhaseNot recorded
    Registry statusCompleted