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AMR Drug RepurposingSmart Screeningresearch prototype

Trypan Blue

FDA-approved product (solution, ophthalmic), marketed as Membraneblue, Visionblue.

Registered studies
23
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Trypan Blue
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Trypan Blue. Its therapeutic class is shown instead.

WHO therapeutic group
Other surgical aids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA45.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae26.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis60.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

23registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Trypan Blue in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Trypan Blue with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Exploratory Evaluation of the BiP Inhibitor BPR001-615 in Primary Cells and the Diagnostic Value of Circulating BiP in Colorectal Adenocarcinomas

    NCT07813884 · start 2026-10-01

    Registered record
    Registry ID
    NCT07813884
    Conditions
    Colorectal Adenocarcinoma
    Interventions
    BPR001-615
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-10-01
    Completion
    2027-10-01
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Adenocarcinoma
    InterventionBPR001-615
    PhaseNot applicable
    Registry statusRecruiting

  • Effect of Trypan Blue on Corneal Endothelial Cell Count During Phacoemulsification

    NCT07735000 · start 2024-03-22

    Registered record
    Registry ID
    NCT07735000
    Conditions
    Age Related Cataract; Cataract
    Interventions
    Trypan Blue; Phacoemulcification
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-03-22
    Completion
    2024-09-22
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAge Related Cataract; Cataract
    InterventionTrypan Blue; Phacoemulcification
    PhaseNot applicable
    Registry statusCompleted

  • The Viability Control of Human Endothelial Cells Before Keratoplasty (V-CHECK) Study

    NCT05847387 · start 2023-12-01

    Registered record
    Registry ID
    NCT05847387
    Conditions
    Corneal Transplant Failure; Corneal Endothelial Cell Loss
    Interventions
    V-Check
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2023-12-01
    Completion
    2026-09-30
    Enrolment
    135

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCorneal Transplant Failure; Corneal Endothelial Cell Loss
    InterventionV-Check
    PhaseNot recorded
    Registry statusRecruiting

  • The Belgian Endothelial Surgical Transplant of the Cornea

    NCT05436665 · start 2022-08-10

    Registered record
    Registry ID
    NCT05436665
    Conditions
    Corneal Edema; Corneal Endothelial Disorder; Fuchs' Endothelial Dystrophy; Bullous Keratopathy; Pseudophakic Bullous Keratopathy
    Interventions
    UT-DSAEK; DMEK
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2022-08-10
    Completion
    2028-06-06
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCorneal Edema; Corneal Endothelial Disorder; Fuchs' Endothelial Dystrophy; Bullous Keratopathy +1 more
    InterventionUT-DSAEK; DMEK
    PhaseNot applicable
    Registry statusActive not recruiting

  • Combined Phacoaspiration and Angle Surgery Versus Phacoaspiration in Pediatric Cataract

    NCT05401760 · start 2022-05-30

    Registered record
    Registry ID
    NCT05401760
    Conditions
    Pediatric Glaucoma
    Interventions
    Group A :combined phacoaspiration and angle surgery; Group B : phacoaspiration only
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-05-30
    Completion
    2023-03-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric Glaucoma
    InterventionGroup A :combined phacoaspiration and angle surgery; Group B : phacoaspiration only
    PhaseNot applicable
    Registry statusUnknown

  • Impact of ILM Peeling in RRD/ I-Peel

    NCT04767555 · start 2022-02-23

    Registered record
    Registry ID
    NCT04767555
    Conditions
    Retinal Detachment
    Interventions
    ILM (inner limiting membrane) peeling
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2022-02-23
    Completion
    2026-06
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRetinal Detachment
    InterventionILM (inner limiting membrane) peeling
    PhaseNot applicable
    Registry statusActive not recruiting

  • Endothelial Side Up Inverted Femtosecond Laser Assisted DSAEK

    NCT06652321 · start 2022-01-01

    Registered record
    Registry ID
    NCT06652321
    Conditions
    Pseudophakic Bullous Keratopathy; Fuchs' Endothelial Dystrophy
    Interventions
    Endothelial Side Up Femtosecond Laser Assisted DSAEK
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-01-01
    Completion
    2024-11-30
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPseudophakic Bullous Keratopathy; Fuchs' Endothelial Dystrophy
    InterventionEndothelial Side Up Femtosecond Laser Assisted DSAEK
    PhaseNot applicable
    Registry statusUnknown

  • Autologous Adipose Derived Stem Cells Transplantation in the Treatment of Keloids.

    NCT04553159 · start 2021-03-01

    Registered record
    Registry ID
    NCT04553159
    Conditions
    Keloid; Autologus Adipose Derived Stem Cells; Feasibility; Safety
    Interventions
    Autologous adipose derived stem cells
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-03-01
    Completion
    2021-06-16
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeloid; Autologus Adipose Derived Stem Cells; Feasibility; Safety
    InterventionAutologous adipose derived stem cells
    PhasePhase 2
    Registry statusCompleted

  • Evaluation of the Efficacy and Tolerability of Autologous Adipose Tissue Derived Stem Cells on Facial Rejuvenation

    NCT03928444 · start 2019-01-01

    Registered record
    Registry ID
    NCT03928444
    Conditions
    Skin Rejuvenation
    Interventions
    intradermal injection of adipose derived stem cells to one side of the face; intradermal injection of saline to one side of the face
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-01-01
    Completion
    2019-08-06
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Rejuvenation
    Interventionintradermal injection of adipose derived stem cells to one side of the face; intradermal injection of saline to one side of the face
    PhaseNot applicable
    Registry statusCompleted

  • Outcomes Based on the Pre-operative Integrity of IS/OS Junction in Idiopathic Epimacular Membrane Surgery

    NCT04158791 · start 2018-03-25

    Registered record
    Registry ID
    NCT04158791
    Conditions
    Epimacular Membrane
    Interventions
    pars plana vitrectomy with epimacular membrane removal and internal limiting membrane peeling
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-03-25
    Completion
    2019-07-09
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpimacular Membrane
    Interventionpars plana vitrectomy with epimacular membrane removal and internal limiting membrane peeling
    PhaseNot recorded
    Registry statusCompleted

  • Safety of Trypan Blue on Endothelium of Diabetic Retinopathy Patients

    NCT03755752 · start 2018-01-01

    Registered record
    Registry ID
    NCT03755752
    Conditions
    Cataract Diabetic
    Interventions
    Phacoemulsification with and without Trypan Blue capsule staining
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-01-01
    Completion
    2018-08-31
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCataract Diabetic
    InterventionPhacoemulsification with and without Trypan Blue capsule staining
    PhaseNot applicable
    Registry statusCompleted

  • Using a Type of Blue Dye to Observe Bleb Function During Cataract Surgery

    NCT02526706 · start 2015-08

    Registered record
    Registry ID
    NCT02526706
    Conditions
    Glaucoma
    Interventions
    VisionBlue
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-08
    Completion
    2016-10
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma
    InterventionVisionBlue
    PhaseNot applicable
    Registry statusCompleted

  • Descemet Endothelial Thickness Comparison Trial

    NCT02373137 · start 2015-01-22

    Registered record
    Registry ID
    NCT02373137
    Conditions
    Keratoplasty; Grafting, Corneal; Transplantation, Corneal; Transplantation, Cornea; Keratoplasty, Lamellar
    Interventions
    DSAEK; DMEK; Endoserter; Prednisolone; Ofloxacin; Tropicamide; Phenylephrine; Jones Tube
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-01-22
    Completion
    2023-05-30
    Enrolment
    38

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeratoplasty; Grafting, Corneal; Transplantation, Corneal; Transplantation, Cornea +1 more
    InterventionDSAEK; DMEK; Endoserter; Prednisolone +4 more
    PhasePhase 4
    Registry statusUnknown

  • Prospective, Single-blind Study Assessing the Benefit/Risk Ratio of Internal Limiting Membrane (ILM) Peeling During Epimacular Membrane (EMM) Surgery (Peeling)

    NCT02146144 · start 2014-09-09

    Registered record
    Registry ID
    NCT02146144
    Conditions
    Idiopathic Epimacular Membrane
    Interventions
    ILM Peeling
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-09-09
    Completion
    2022-03-14
    Enrolment
    213

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIdiopathic Epimacular Membrane
    InterventionILM Peeling
    PhaseNot applicable
    Registry statusCompleted

  • Monocyte Activation in Preclinical Atherosclerosis

    NCT02126280 · start 2012-11

    Registered record
    Registry ID
    NCT02126280
    Conditions
    Atherosclerosis
    Interventions
    In vitro estimation of individual reactivity of monocytes
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-11
    Completion
    2014-04
    Enrolment
    170

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtherosclerosis
    InterventionIn vitro estimation of individual reactivity of monocytes
    PhaseNot recorded
    Registry statusCompleted