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AMR Drug RepurposingSmart Screeningresearch prototype

Ceftaroline Fosamil

FDA-approved product (powder, intravenous), marketed as Ceftaroline Fosamil, Teflaro.

Registered studies
50+
Lab records
19
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Ceftaroline Fosamil
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Bacterial infectious disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other cephalosporins and penems
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DI02

Repurposing investigation

Ceftaroline Fosamil is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA75.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli74.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae92.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis49.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 13 of 19 lab records
Open Ceftaroline Fosamil in ChEMBL Registered studies below
Show the 19 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ceftaroline Fosamil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • IL-10 Stratifying Tool for Towards Antibiotic Selection for MRSaB

    NCT02660346 · start 2015-11

    Registered record
    Registry ID
    NCT02660346
    Conditions
    Bacteremia
    Interventions
    Daptomycin; Vancomycin; Ceftaroline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-11
    Completion
    2018-01-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia
    InterventionDaptomycin; Vancomycin; Ceftaroline
    PhasePhase 4
    Registry statusCompleted

  • Safety, Tolerability and Efficacy of Ceftaroline in Paediatrics With Late-Onset Sepsis

    NCT02424734 · start 2015-08-04

    Registered record
    Registry ID
    NCT02424734
    Conditions
    Late-onset Sepsis
    Interventions
    Ceftaroline Fosamil; Ampicillin; Aminoglycoside
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2015-08-04
    Completion
    2017-12-26
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLate-onset Sepsis
    InterventionCeftaroline Fosamil; Ampicillin; Aminoglycoside
    PhasePhase 2
    Registry statusTerminated

  • Ceftaroline for Treatment of Hematogenously Acquired Staphylococcus Aureus Osteomyelitis in Children

    NCT02335905 · start 2015-06-03

    Registered record
    Registry ID
    NCT02335905
    Conditions
    Hematogenously Acquired Staphylococcus Aureus Osteomyelitis; Bone Infection; Osteomyelitis
    Interventions
    Ceftaroline Fosamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2015-06-03
    Completion
    2020-06-16
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHematogenously Acquired Staphylococcus Aureus Osteomyelitis; Bone Infection; Osteomyelitis
    InterventionCeftaroline Fosamil
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Penetration of Ceftaroline Into Cerebrospinal Fluid(CSF)

    NCT02806882 · start 2015-04-29

    Registered record
    Registry ID
    NCT02806882
    Conditions
    Meningitis; Ventriculitis
    Interventions
    Ceftaroline fosamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-04-29
    Completion
    2016-10-24
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMeningitis; Ventriculitis
    InterventionCeftaroline fosamil
    PhasePhase 1
    Registry statusCompleted

  • The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection

    NCT02307006 · start 2015-01

    Registered record
    Registry ID
    NCT02307006
    Conditions
    Surgical Site Infection
    Interventions
    Ceftaroline; Cefazolin / Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-01
    Completion
    2017-06
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    InterventionCeftaroline; Cefazolin / Vancomycin
    PhasePhase 4
    Registry statusUnknown

  • Evaluation of Ceftaroline Fosamil vs Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections.

    NCT02202135 · start 2014-06

    Registered record
    Registry ID
    NCT02202135
    Conditions
    Complicated Skin and Soft Tissue Infection
    Interventions
    Ceftaroline fosamil; Vancomycin; Aztreonam
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2014-06
    Completion
    2015-01
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplicated Skin and Soft Tissue Infection
    InterventionCeftaroline fosamil; Vancomycin; Aztreonam
    PhasePhase 3
    Registry statusTerminated

  • A Study to Investigate the Effect of Administration of Ceftazidime-avibactam (CAZ-AVI) and Ceftaroline Fosamil -Avibactam (CXL) on the Intestinal Flora of Healthy Volunteers

    NCT01789528 · start 2013-08

    Registered record
    Registry ID
    NCT01789528
    Conditions
    Pharmacokinetics; Open Label; CAZ-AVI; CXL; Effect on Intestinal Flora; Safety
    Interventions
    CAZ-AVI; CXL
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-08
    Completion
    2014-03
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacokinetics; Open Label; CAZ-AVI; CXL +2 more
    InterventionCAZ-AVI; CXL
    PhasePhase 1
    Registry statusCompleted

  • Antibiotic Stewardship in Small Hospitals

    NCT03245879 · start 2013-07

    Registered record
    Registry ID
    NCT03245879
    Conditions
    Inappropriate Prescribing; Antibiotic Stewardship; Anti-Bacterial Agents
    Interventions
    Program 1; Program 2; Program 3
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-07
    Completion
    2015-06
    Enrolment
    30,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInappropriate Prescribing; Antibiotic Stewardship; Anti-Bacterial Agents
    InterventionProgram 1; Program 2; Program 3
    PhaseNot applicable
    Registry statusCompleted

  • Ceftaroline in the Treatment of Bone and Joint Infections

    NCT02005068 · start 2013-04

    Registered record
    Registry ID
    NCT02005068
    Conditions
    Osteomyelitis; Joint Infections
    Interventions
    Ceftaroline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2013-04
    Completion
    2014-07
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis; Joint Infections
    InterventionCeftaroline
    PhasePhase 4
    Registry statusWithdrawn

  • A Study to Assess the Pharmacokinetics of Ceftaroline in End Stage Renal Disease Patients and Matched Healthy Subjects

    NCT01664065 · start 2013-02

    Registered record
    Registry ID
    NCT01664065
    Conditions
    Renal Disease
    Interventions
    200 mg Ceftaroline fosamil; 600 mg Ceftaroline fosamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-02
    Completion
    2013-11
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Disease
    Intervention200 mg Ceftaroline fosamil; 600 mg Ceftaroline fosamil
    PhasePhase 1
    Registry statusCompleted

  • Safety and Efficacy Study of Ceftaroline in Subjects With Staphylococcus Aureus Bacteremia or With Persistent Methicillin-Resistant Staphylococcus Aureus Bacteremia

    NCT01701219 · start 2013-01

    Registered record
    Registry ID
    NCT01701219
    Conditions
    Staphylococcus Aureus Bacteremia; Methicillin-resistant Staphylococcus Aureus (MRSA) Bacteremia
    Interventions
    Ceftaroline fosamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-01
    Completion
    2014-07
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia; Methicillin-resistant Staphylococcus Aureus (MRSA) Bacteremia
    InterventionCeftaroline fosamil
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection

    NCT01756924 · start 2012-12

    Registered record
    Registry ID
    NCT01756924
    Conditions
    Prosthetic Joint Infections of Hip; Prosthetic Joint Infections of Knee; Infected Spacers
    Interventions
    CEM-102; IV or Oral standard of care antibiotics; Rifampin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2012-12
    Completion
    2014-07
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProsthetic Joint Infections of Hip; Prosthetic Joint Infections of Knee; Infected Spacers
    InterventionCEM-102; IV or Oral standard of care antibiotics; Rifampin
    PhasePhase 2
    Registry statusTerminated

  • Safety and Efficacy Study of Ceftaroline in Elderly Subjects With Community-Acquired Bacterial Pneumonia

    NCT01666743 · start 2012-11

    Registered record
    Registry ID
    NCT01666743
    Conditions
    Community-Acquired Bacterial Pneumonia (CABP)
    Interventions
    Ceftaroline fosamil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2012-11
    Completion
    2014-03
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-Acquired Bacterial Pneumonia (CABP)
    InterventionCeftaroline fosamil
    PhasePhase 4
    Registry statusWithdrawn

  • Evaluation of Ceftaroline Fosamil Versus a Comparator in Adult Subjects With Community-acquired Bacterial Pneumonia (CABP) With Risk for Methicillin-resistant Staphylococcus Aureus

    NCT01645735 · start 2012-10

    Registered record
    Registry ID
    NCT01645735
    Conditions
    Infections
    Interventions
    Ceftaroline fosamil; Ceftriaxone plus vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-10
    Completion
    2013-12
    Enrolment
    49

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections
    InterventionCeftaroline fosamil; Ceftriaxone plus vancomycin
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Complicated Community Acquired Pneumonia (CABP)

    NCT01669980 · start 2012-10

    Registered record
    Registry ID
    NCT01669980
    Conditions
    Infections; Pneumonia
    Interventions
    Ceftaroline fosamil; IV Ceftriaxone and Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-10
    Completion
    2014-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections; Pneumonia
    InterventionCeftaroline fosamil; IV Ceftriaxone and Vancomycin
    PhasePhase 4
    Registry statusCompleted