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AMR Drug RepurposingSmart Screeningresearch prototype

Fludeoxyglucose F-18

FDA-approved product (injectable, injection), marketed as Fludeoxyglucose F18.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Fludeoxyglucose F-18
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Fludeoxyglucose F-18. Its therapeutic class is shown instead.

WHO therapeutic group
Other diagnostic radiopharmaceuticals for tumour detection
FDA pharmacologic class
Radioactive Diagnostic Agent FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Fludeoxyglucose F-18, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA18.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli6.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae21.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis13.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Fludeoxyglucose F-18 in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Fludeoxyglucose F-18 with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • PET/MR Imaging In Patients With Cardiac Sarcoidosis

    NCT03705884 · start 2017-10-30

    Registered record
    Registry ID
    NCT03705884
    Conditions
    Cardiac Sarcoidosis
    Interventions
    18F-FDG; Prednisolone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-10-30
    Completion
    2018-12-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiac Sarcoidosis
    Intervention18F-FDG; Prednisolone
    PhaseNot applicable
    Registry statusCompleted

  • Non-alcoholic Fatty Liver Disease Parametric PET (FLiPP) Study

    NCT02754037 · start 2016-04-30

    Registered record
    Registry ID
    NCT02754037
    Conditions
    Non-alcoholic Fatty Liver Disease (NAFLD); Non-alcoholic Steatohepatitis (NASH)
    Interventions
    Fluorodeoxyglucose (FDG) positron emission tomography (PET); Magnetic resonance imaging (MRI); PET Explorer
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2016-04-30
    Completion
    2026-06-30
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-alcoholic Fatty Liver Disease (NAFLD); Non-alcoholic Steatohepatitis (NASH)
    InterventionFluorodeoxyglucose (FDG) positron emission tomography (PET); Magnetic resonance imaging (MRI); PET Explorer
    PhaseNot recorded
    Registry statusActive not recruiting

  • PET Combined With MRI for Monitoring Inflammatory Activity in Patients With Ulcerative Colitis

    NCT03781284 · start 2016-01-01

    Registered record
    Registry ID
    NCT03781284
    Conditions
    Ulcerative Colitis
    Interventions
    [18F]-FDG PET/MRI; Colonoscopy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-01-01
    Completion
    2018-10-31
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUlcerative Colitis
    Intervention[18F]-FDG PET/MRI; Colonoscopy
    PhaseNot applicable
    Registry statusCompleted

  • Use of PET/MR Imaging in Chronic Pain

    NCT03195270 · start 2014-11-24

    Registered record
    Registry ID
    NCT03195270
    Conditions
    Chronic Pain
    Interventions
    [18F]FDG; PET/MRI
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-11-24
    Completion
    2022-01-20
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Pain
    Intervention[18F]FDG; PET/MRI
    PhasePhase 1
    Registry statusCompleted

  • Intestinal Remodeling And Reprogramming of Glucose Metabolism Following Laparoscopic Roux-en-Y Gastric Bypass

    NCT02288351 · start 2014-11

    Registered record
    Registry ID
    NCT02288351
    Conditions
    Type 2 Diabetes; Obesity
    Interventions
    Mix Nutrient Meal; labs; Biopsy; Second Mix Nutrient Meal; Second biopsy; PET/CT
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2014-11
    Completion
    2015-04
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 2 Diabetes; Obesity
    InterventionMix Nutrient Meal; labs; Biopsy; Second Mix Nutrient Meal +2 more
    PhaseNot applicable
    Registry statusWithdrawn

  • 68Ga-AlfatideII for the Differential Diagnosis of of Lung Cancer and Lung Tuberculosis by PET/CT

    NCT02481726 · start 2014-03

    Registered record
    Registry ID
    NCT02481726
    Conditions
    Lung Cancer; Lung Tuberculosis
    Interventions
    68Ga-labeled peptides of dimer RGD (Alfatide II) and 18F-FDG
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2014-03
    Completion
    Not recorded
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLung Cancer; Lung Tuberculosis
    Intervention68Ga-labeled peptides of dimer RGD (Alfatide II) and 18F-FDG
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Early Interim 18F-FDG-PET and 18F-FLT-PET for Predicting Treatment Response and Survival in Metastatic Breast Cancer

    NCT04411966 · start 2014-01-01

    Registered record
    Registry ID
    NCT04411966
    Conditions
    Metastatic Breast Cancer
    Interventions
    18F-fluorothymidine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-01-01
    Completion
    2019-05-30
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetastatic Breast Cancer
    Intervention18F-fluorothymidine
    PhaseNot applicable
    Registry statusCompleted

  • Functional Brain Imaging in PTSD

    NCT02053532 · start 2013-05

    Registered record
    Registry ID
    NCT02053532
    Conditions
    Post-traumatic Stress Disorder (PTSD); Trauma
    Interventions
    Positron emission tomography/magnetic resonance imaging
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-05
    Completion
    2016-02
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-traumatic Stress Disorder (PTSD); Trauma
    InterventionPositron emission tomography/magnetic resonance imaging
    PhaseNot recorded
    Registry statusCompleted

  • Performance of PET 18 F-FDG Coupled to CT With Contrast Injection Iodized in the Diagnosis of Early Recurrences of Head and Neck Carcinoma Treated With Concurrent Chemoradiation. Comparison With 18F-FDG PET Coupled With CT Not Injected With Filling CT Standard Injection

    NCT02510872 · start 2011-12

    Registered record
    Registry ID
    NCT02510872
    Conditions
    Squamous Cell Carcinoma of the Head and Neck
    Interventions
    18F-FDG PET combined with CT with iodinated contrast injection; 18F-FDG PET combined with CT without injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-12
    Completion
    Not recorded
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSquamous Cell Carcinoma of the Head and Neck
    Intervention18F-FDG PET combined with CT with iodinated contrast injection; 18F-FDG PET combined with CT without injection
    PhaseNot applicable
    Registry statusCompleted

  • Predictive Value of FDG PET/CT, DWI and DCE-MRI Scans for Non-small Cell Lung Cancer Patients Receiving Chemotherapy

    NCT01482182 · start 2011-11

    Registered record
    Registry ID
    NCT01482182
    Conditions
    Non-small Cell Lung Cancer
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-11
    Completion
    2014-01
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-small Cell Lung Cancer
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • MRI and PET-CT for Radiotherapy Planning for Head and Neck Cancer

    NCT02273778 · start 2011-06

    Registered record
    Registry ID
    NCT02273778
    Conditions
    Head and Neck Cancer
    Interventions
    MRI Scan; PET-CT Scan; No intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-06
    Completion
    2013-06
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHead and Neck Cancer
    InterventionMRI Scan; PET-CT Scan; No intervention
    PhaseNot applicable
    Registry statusCompleted

  • Cediranib, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma

    NCT00662506 · start 2008-04

    Registered record
    Registry ID
    NCT00662506
    Conditions
    Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma
    Interventions
    Cediranib Maleate; Diffusion Tensor Imaging; Diffusion Weighted Imaging; Dynamic Contrast-Enhanced Magnetic Resonance Imaging; Fludeoxyglucose F-18; Intensity-Modulated Radiation Therapy; Laboratory Biomarker Analysis; Perfusion Magnetic Resonance Imaging; Positron Emission Tomography; Temozolomide
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2008-04
    Completion
    2014-04
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma
    InterventionCediranib Maleate; Diffusion Tensor Imaging; Diffusion Weighted Imaging; Dynamic Contrast-Enhanced Magnetic Resonance Imaging +6 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Observation Study for Prediction of Allograft Survival and Impact of Imaging in Kidney Transplant Recipients.

    NCT03764124 · start 2007-01-01

    Registered record
    Registry ID
    NCT03764124
    Conditions
    Kidney Transplantation
    Interventions
    PET/CT imaging
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2007-01-01
    Completion
    2024-08
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Transplantation
    InterventionPET/CT imaging
    PhaseNot recorded
    Registry statusUnknown

  • Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET) in Cancer Associated Venothromboembolism

    NCT01107327 · start 2006-08

    Registered record
    Registry ID
    NCT01107327
    Conditions
    Venothromboembolism
    Interventions
    FDG-PET/CT
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-08
    Completion
    2012-01
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVenothromboembolism
    InterventionFDG-PET/CT
    PhaseNot recorded
    Registry statusCompleted

  • Whole-Body 18F-FDG PET in Induction Chemotherapeutic Response for Advanced NPC Patients

    NCT00304694 · start 2006-03

    Registered record
    Registry ID
    NCT00304694
    Conditions
    Nasopharyngeal Cancer
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2006-03
    Completion
    Not recorded
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNasopharyngeal Cancer
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown