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AMR Drug RepurposingSmart Screeningresearch prototype

Minoxidil

FDA-approved product (tablet, oral), marketed as Loniten, Men's Rogaine, Minodyl and 9 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Minoxidil
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Alopecia
  • Androgenetic alopecia
  • Hypertension
  • Hypotrichosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Pyrimidine derivatives; Other dermatologicals
FDA pharmacologic class
Arteriolar Vasodilator FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA29.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli28.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Minoxidil in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Minoxidil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Minoxidil With or Without Low-Level Red-Light Therapy for Improving Chemotherapy-Induced Alopecia in Breast Cancer Patients

    NCT07594678 · start 2026-11-15

    Registered record
    Registry ID
    NCT07594678
    Conditions
    Anatomic Stage I Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Chemotherapy-Induced Alopecia
    Interventions
    Electronic Health Record Review; Minoxidil; Revian RED LED-light cap; Survey Administration
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2026-11-15
    Completion
    2027-12-31
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnatomic Stage I Breast Cancer AJCC v8; Anatomic Stage II Breast Cancer AJCC v8; Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8 +1 more
    InterventionElectronic Health Record Review; Minoxidil; Revian RED LED-light cap; Survey Administration
    PhasePhase 2
    Registry statusNot yet recruiting

  • For an Investigator-led Hair Study Comparing Between Healthy and Hair Loss Volunteers

    NCT07716748 · start 2026-08

    Registered record
    Registry ID
    NCT07716748
    Conditions
    Hair Loss
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Not yet recruiting
    Start
    2026-08
    Completion
    2028-01
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHair Loss
    InterventionNot recorded
    PhaseNot recorded
    Registry statusNot yet recruiting

  • VENEZE Peptide Factor Hair Serum Compared With Topical 2% Minoxidil for Androgenetic Alopecia

    NCT07536100 · start 2026-05-05

    Registered record
    Registry ID
    NCT07536100
    Conditions
    Androgenetic Alopecia (AGA)
    Interventions
    Veneze peptide hair serum; Topical minoxidil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-05-05
    Completion
    2026-11-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia (AGA)
    InterventionVeneze peptide hair serum; Topical minoxidil
    PhaseNot applicable
    Registry statusRecruiting

  • Androgenic Alopecia TH07 Clinical Trial

    NCT07435012 · start 2026-04

    Registered record
    Registry ID
    NCT07435012
    Conditions
    Androgenic Alopecia
    Interventions
    TH07; TH07; Minoxidil 5% Topical Solution; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2026-04
    Completion
    2028-04
    Enrolment
    420

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenic Alopecia
    InterventionTH07; TH07; Minoxidil 5% Topical Solution; Placebo
    PhasePhase 3
    Registry statusRecruiting

  • Effects of a Topical Serum Solution on Hair Characteristics

    NCT07785869 · start 2026-01-26

    Registered record
    Registry ID
    NCT07785869
    Conditions
    Hair Characteristics
    Interventions
    Re:You Hair Revival Serum 1; Re:You Hair Revival Serum 2; Topical Minoxidil 2%
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2026-01-26
    Completion
    2026-09-25
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHair Characteristics
    InterventionRe:You Hair Revival Serum 1; Re:You Hair Revival Serum 2; Topical Minoxidil 2%
    PhaseNot applicable
    Registry statusActive not recruiting

  • Topical Application of Lactobacillus Reuteri for Androgenetic Alopecia

    NCT07370519 · start 2026-01-25

    Registered record
    Registry ID
    NCT07370519
    Conditions
    Androgenetic Alopecia (AGA)
    Interventions
    Lactobacillus reuteri; Inactivated Lactobacillus reuteri; 5% Minoxidil; Normal Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2026-01-25
    Completion
    2027-06
    Enrolment
    388

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia (AGA)
    InterventionLactobacillus reuteri; Inactivated Lactobacillus reuteri; 5% Minoxidil; Normal Saline
    PhasePhase 2
    Registry statusRecruiting

  • Topical 2-Deoxy-D-ribose Hydrogel Versus Minoxidil 5% Solution for Androgenetic Alopecia

    NCT07502976 · start 2026-01-01

    Registered record
    Registry ID
    NCT07502976
    Conditions
    Androgenic Alopecia
    Interventions
    Topical 2-Deoxy-D-ribose Hydrogel; Topical Minoxidil 5% Solution
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-01-01
    Completion
    2027-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenic Alopecia
    InterventionTopical 2-Deoxy-D-ribose Hydrogel; Topical Minoxidil 5% Solution
    PhaseNot applicable
    Registry statusRecruiting

  • Comparison of Outcomes Between Topical Minoxidil Versus Oral Minoxidil for the Treatment of Androgenetic Alopecia

    NCT07273799 · start 2025-12-20

    Registered record
    Registry ID
    NCT07273799
    Conditions
    Androgenic Alopecia
    Interventions
    Minoxidil 5 % Topical Spray; minoxidil; Placebo Spray; Placebo Tablet or Capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2025-12-20
    Completion
    2026-06-01
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenic Alopecia
    InterventionMinoxidil 5 % Topical Spray; minoxidil; Placebo Spray; Placebo Tablet or Capsule
    PhasePhase 3
    Registry statusNot yet recruiting

  • Effect of Minoxidil Solution Iontophoresis on Androgenic Alopecia

    NCT07056933 · start 2025-07-08

    Registered record
    Registry ID
    NCT07056933
    Conditions
    Alopecia
    Interventions
    Minoxidil solution iontophoresis; saline solution iontophoresis
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2025-07-08
    Completion
    2025-11-30
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlopecia
    InterventionMinoxidil solution iontophoresis; saline solution iontophoresis
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Low Dose Oral Minoxdil in Androgenic Alopecia

    NCT07018349 · start 2025-06-15

    Registered record
    Registry ID
    NCT07018349
    Conditions
    Androgenetic Alopecia (AGA)
    Interventions
    2.5% Oral minoxidil; 1% Oral Minoxidil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2025-06-15
    Completion
    2025-10-20
    Enrolment
    76

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia (AGA)
    Intervention2.5% Oral minoxidil; 1% Oral Minoxidil
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Efficacy of Dihydroartemisinin for Treating Female Androgenetic Alopecia

    NCT07012486 · start 2025-06

    Registered record
    Registry ID
    NCT07012486
    Conditions
    Androgenetic Alopecia (AGA)
    Interventions
    Oral DHA + Topical minoxidil 5%; Topical Minoxidil 5%
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Recruiting
    Start
    2025-06
    Completion
    2026-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia (AGA)
    InterventionOral DHA + Topical minoxidil 5%; Topical Minoxidil 5%
    PhaseEarly phase 1
    Registry statusRecruiting

  • Minoxidil for Treating White Hair: A Randomized Controlled Trial

    NCT06813963 · start 2025-02-15

    Registered record
    Registry ID
    NCT06813963
    Conditions
    Grey Hair
    Interventions
    Topical Minoxidil（5%） to the scalp.; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2025-02-15
    Completion
    2026-03-15
    Enrolment
    141

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGrey Hair
    InterventionTopical Minoxidil（5%） to the scalp.; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Various Procedural Treatment Options for Androgenetic Alopecia

    NCT06826001 · start 2025-02

    Registered record
    Registry ID
    NCT06826001
    Conditions
    Androgenetic Alopecia
    Interventions
    topical finasteride; Topical minoxidil
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Not yet recruiting
    Start
    2025-02
    Completion
    2025-07
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia
    Interventiontopical finasteride; Topical minoxidil
    PhasePhase 2
    Registry statusNot yet recruiting

  • Clinical Study of PRP in the Treatment of Androgenetic Alopecia

    NCT07551271 · start 2025-01-01

    Registered record
    Registry ID
    NCT07551271
    Conditions
    Androgenetic Alopecia (AGA)
    Interventions
    PRP
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-01-01
    Completion
    2026-03-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia (AGA)
    InterventionPRP
    PhaseNot applicable
    Registry statusCompleted

  • Proof-of-Science, Prospective, Interventional, Three-arm, Double-Blind, Randomized, Safety and Efficacy Real World Evidence Study.

    NCT06552039 · start 2024-12-26

    Registered record
    Registry ID
    NCT06552039
    Conditions
    Hair Fall and Pre-mature Graying
    Interventions
    Polyherbal Hair Oil; Minoxidil Herbal Hair Oil + Minoxidil 5 (%) Hair Serum; Minoxidil Hair Serum
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-12-26
    Completion
    2025-06-28
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHair Fall and Pre-mature Graying
    InterventionPolyherbal Hair Oil; Minoxidil Herbal Hair Oil + Minoxidil 5 (%) Hair Serum; Minoxidil Hair Serum
    PhaseNot applicable
    Registry statusCompleted