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AMR Drug RepurposingSmart Screeningresearch prototype

Minoxidil

FDA-approved product (tablet, oral), marketed as Loniten, Men's Rogaine, Minodyl and 9 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Minoxidil
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Alopecia
  • Androgenetic alopecia
  • Hypertension
  • Hypotrichosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Pyrimidine derivatives; Other dermatologicals
FDA pharmacologic class
Arteriolar Vasodilator FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA29.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli28.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Minoxidil in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Minoxidil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Clinical Trial to Evaluate CG2001 in Chinese Adult Male Participants With Androgenetic Alopecia

    NCT07076706 · start 2024-12-05

    Registered record
    Registry ID
    NCT07076706
    Conditions
    Male Pattern of Hair Loss, Androgenic Alopecia; Androgenetic Alopecia (AGA)
    Interventions
    minoxidil + finasteride; minoxidil + finasteride; Placebo foam
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2024-12-05
    Completion
    2025-09-23
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMale Pattern of Hair Loss, Androgenic Alopecia; Androgenetic Alopecia (AGA)
    Interventionminoxidil + finasteride; minoxidil + finasteride; Placebo foam
    PhasePhase 2
    Registry statusCompleted

  • Evaluation of Efficacy and Safety of Oral Minoxidil 1 mg in Female Androgenetic Alopecia

    NCT05888922 · start 2024-10-17

    Registered record
    Registry ID
    NCT05888922
    Conditions
    Androgenetic Alopecia; Female Pattern Baldness
    Interventions
    Minoxidil Tablets; Minoxidil Topical; Placebo oral tablet; Vehicle solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Active not recruiting
    Start
    2024-10-17
    Completion
    2026-11-16
    Enrolment
    520

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia; Female Pattern Baldness
    InterventionMinoxidil Tablets; Minoxidil Topical; Placebo oral tablet; Vehicle solution
    PhasePhase 3
    Registry statusActive not recruiting

  • Clinical Study of Probiotic Treatment for Androgenetic Alopecia

    NCT06484881 · start 2024-09-15

    Registered record
    Registry ID
    NCT06484881
    Conditions
    Androgenetic Alopecia; Female Pattern Baldness
    Interventions
    Daniel Alain Probiotic Treatment for Androgenetic Alopecia; Topical minoxidil 5%
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2024-09-15
    Completion
    2024-10-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia; Female Pattern Baldness
    InterventionDaniel Alain Probiotic Treatment for Androgenetic Alopecia; Topical minoxidil 5%
    PhasePhase 3
    Registry statusWithdrawn

  • Phase I Clinical Trial of CG2001 in Chinese Adult Male Participants With Androgenetic Alopecia

    NCT07038941 · start 2024-03-19

    Registered record
    Registry ID
    NCT07038941
    Conditions
    Male Pattern of Hair Loss, Androgenic Alopecia; Androgenetic Alopecia (AGA)
    Interventions
    CG2001; Placebo foam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2024-03-19
    Completion
    2024-06-02
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMale Pattern of Hair Loss, Androgenic Alopecia; Androgenetic Alopecia (AGA)
    InterventionCG2001; Placebo foam
    PhasePhase 1
    Registry statusCompleted

  • Comparison of Microneedling vs. Autologous Concentrated Growth Factor for the Treatment of Female Androgenetic Alopecia

    NCT06218394 · start 2023-12-14

    Registered record
    Registry ID
    NCT06218394
    Conditions
    Androgenetic Alopecia
    Interventions
    microneedling; Autologous Concentrated Growth Factor; 5% minoxidil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-12-14
    Completion
    2024-12-31
    Enrolment
    135

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia
    Interventionmicroneedling; Autologous Concentrated Growth Factor; 5% minoxidil
    PhaseNot applicable
    Registry statusUnknown

  • Hair Regeneration in Androgenetic Alopecia

    NCT06066827 · start 2023-08-14

    Registered record
    Registry ID
    NCT06066827
    Conditions
    Androgenetic Alopecia
    Interventions
    Minoxidil Topical; Secretome from adipose-derived stem cells; Combination of minoxidil and secretome from adipose-derived stem cells
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-08-14
    Completion
    2023-11-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia
    InterventionMinoxidil Topical; Secretome from adipose-derived stem cells; Combination of minoxidil and secretome from adipose-derived stem cells
    PhaseNot applicable
    Registry statusUnknown

  • Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne Vulgaris

    NCT06108193 · start 2023-07-11

    Registered record
    Registry ID
    NCT06108193
    Conditions
    Acne Vulgaris
    Interventions
    topical minoxidil in Acne Vulgaris
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2023-07-11
    Completion
    2023-12-31
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    Interventiontopical minoxidil in Acne Vulgaris
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • Effectiveness and Safety of Topical Finasteride and Minoxidil Combination Compared to Topical Minoxidil for The Treatment of Male Androgenetic Alopecia

    NCT05990400 · start 2023-05-01

    Registered record
    Registry ID
    NCT05990400
    Conditions
    Androgenetic Alopecia
    Interventions
    Finasteride; Minoxidil
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2023-05-01
    Completion
    2023-12-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia
    InterventionFinasteride; Minoxidil
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Proof of Concept Study of Latanoprost/Minoxidil (ANR-001.1) Topical Formulation

    NCT05790941 · start 2023-03-11

    Registered record
    Registry ID
    NCT05790941
    Conditions
    Hypotrichosis
    Interventions
    Latanoprost and Minoxidil
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2023-03-11
    Completion
    2023-06-30
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypotrichosis
    InterventionLatanoprost and Minoxidil
    PhaseEarly phase 1
    Registry statusUnknown

  • A Study of Oral Minoxidil to Treat Hair Loss in Children, Teens, and Young Adults Who Are Cancer Survivors

    NCT05778825 · start 2023-03-10

    Registered record
    Registry ID
    NCT05778825
    Conditions
    Survivors of Childhood Cancer; Alopecia
    Interventions
    Oral Minoxidil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2023-03-10
    Completion
    2027-03
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurvivors of Childhood Cancer; Alopecia
    InterventionOral Minoxidil; Placebo
    PhasePhase 2
    Registry statusActive not recruiting

  • Treatment of Androgenetic Alopecia in Men for 24 Weeks

    NCT04721548 · start 2023-03-02

    Registered record
    Registry ID
    NCT04721548
    Conditions
    Alopecia
    Interventions
    Minoxidil Topical Foam; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2023-03-02
    Completion
    2024-03-06
    Enrolment
    336

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlopecia
    InterventionMinoxidil Topical Foam; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Role of Minoxidil in Alopecia Areata Transepidermal Drug Delivery of Minoxidil Via Either Fractional Carbon Dioxide Laser or Microneedling Versus Its Topical Nanoparticles Preparation for Treatment of Alopecia Areata

    NCT05587257 · start 2023-01-01

    Registered record
    Registry ID
    NCT05587257
    Conditions
    Alopecia Areata
    Interventions
    Fractional CO2 laser; Derma pen; Niosome minoxidil; Minoxidil Topical Spray
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-01-01
    Completion
    2024-02-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlopecia Areata
    InterventionFractional CO2 laser; Derma pen; Niosome minoxidil; Minoxidil Topical Spray
    PhaseNot applicable
    Registry statusUnknown

  • Clinical Application of Stem Cell Educator Therapy in Alopecia Areata

    NCT04011748 · start 2022-09-20

    Registered record
    Registry ID
    NCT04011748
    Conditions
    Alopecia Areata; Alopecia Totalis; Alopecia Universalis
    Interventions
    Stem Cell Educator therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2022-09-20
    Completion
    2023-07-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlopecia Areata; Alopecia Totalis; Alopecia Universalis
    InterventionStem Cell Educator therapy
    PhasePhase 2
    Registry statusUnknown

  • Radiofrequency in Female Pattern Hair Loss

    NCT05409755 · start 2022-06-25

    Registered record
    Registry ID
    NCT05409755
    Conditions
    Female Pattern Baldness
    Interventions
    Vivacy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-06-25
    Completion
    2022-09-15
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFemale Pattern Baldness
    InterventionVivacy
    PhaseNot applicable
    Registry statusUnknown

  • Evaluation of the Effect of HFMT in Promoting Donor-site Wound Healing

    NCT05839158 · start 2022-03-01

    Registered record
    Registry ID
    NCT05839158
    Conditions
    Wound Heal
    Interventions
    HFMT cell suspension; Mupirocin ointment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-03-01
    Completion
    2022-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Heal
    InterventionHFMT cell suspension; Mupirocin ointment
    PhaseNot applicable
    Registry statusCompleted