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AMR Drug RepurposingSmart Screeningresearch prototype

Minoxidil

FDA-approved product (tablet, oral), marketed as Loniten, Men's Rogaine, Minodyl and 9 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Minoxidil
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Alopecia
  • Androgenetic alopecia
  • Hypertension
  • Hypotrichosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Pyrimidine derivatives; Other dermatologicals
FDA pharmacologic class
Arteriolar Vasodilator FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA29.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli28.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Minoxidil in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Minoxidil with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Minoxidil 2% for Eyebrow Enhancement

    NCT01672307 · start 2012-09

    Registered record
    Registry ID
    NCT01672307
    Conditions
    Hypotrichosis of Eyebrows; Thinning Eyebrows
    Interventions
    Minoxidil lotion 2%; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-09
    Completion
    2013-03
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypotrichosis of Eyebrows; Thinning Eyebrows
    InterventionMinoxidil lotion 2%; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Microarray Analysis of Scalp Biopsies After Minoxidil Treatment

    NCT01309191 · start 2011-04

    Registered record
    Registry ID
    NCT01309191
    Conditions
    Androgenetic Alopecia
    Interventions
    Minoxidil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-04
    Completion
    2012-04
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia
    InterventionMinoxidil; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Evaluate and Compare Injections of Autologous Dermal and Epidermal Cells Into the Balding Scalp of Subjects With Hair Loss (CA-0004512)

    NCT01451125 · start 2010-05

    Registered record
    Registry ID
    NCT01451125
    Conditions
    Androgenetic Alopecia; Male Pattern Baldness; Female Pattern Baldness
    Interventions
    Autologous cultured dermal and epidermal cells
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-05
    Completion
    Not recorded
    Enrolment
    43

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia; Male Pattern Baldness; Female Pattern Baldness
    InterventionAutologous cultured dermal and epidermal cells
    PhasePhase 2
    Registry statusCompleted

  • Efficacy of Minoxidil in Children With Williams-Beuren Syndrome

    NCT00876200 · start 2009-03

    Registered record
    Registry ID
    NCT00876200
    Conditions
    Williams Beuren Syndrome
    Interventions
    Minoxidil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-03
    Completion
    2015-08
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWilliams Beuren Syndrome
    InterventionMinoxidil; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Efficacy of Therapy With the Spironolactone Pills Compared to Minoxidil Lotion in Female Pattern Hair Loss

    NCT00175617 · start 2005-09

    Registered record
    Registry ID
    NCT00175617
    Conditions
    Female Pattern Hair Loss
    Interventions
    Spironolactone; Minoxidil
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-09
    Completion
    2009-03-09
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFemale Pattern Hair Loss
    InterventionSpironolactone; Minoxidil
    PhasePhase 2
    Registry statusCompleted