Promazine Hydrochloride
FDA-approved product (tablet, oral), marketed as Promazine Hydrochloride, Sparine.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psychosis
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Phenothiazines with aliphatic side-chain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Promazine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Donepezil HydrochlorideExisting use: Alzheimer disease, Dementia61.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Mobocertinib SuccinateExisting use: Neoplasm, Non-small cell lung carcinoma61.8% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- BaricitinibExisting use: Rheumatoid arthritis61.6% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Caspofungin AcetateExisting use: Aspergillosis, Candidemia, Candidiasis and 1 more61.6% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Ergoloid MesylatesExisting use: Cardiovascular disease61.6% AI-predicted activityagainst M. tuberculosis2 registered studies
- Icatibant AcetateExisting use: Angioedema, Hereditary angioedema61.6% AI-predicted activityagainst M. tuberculosis33 registered studies
- Tenofovir Alafenamide FumarateExisting use: Chronic hepatitis B virus infection, Hepatitis B virus infection, HIV infection and 2 more61.6% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Triptorelin PamoateExisting use: Central precocious puberty, Metastatic prostate cancer, Neoplasm and 3 more61.5% AI-predicted activityagainst M. tuberculosis50+ registered studies
- IloperidoneExisting use: Psychosis, Schizophrenia61.5% AI-predicted activityagainst M. tuberculosis32 registered studies
- Ganirelix AcetateExisting use: Female infertility, Positive regulation of ovulation, Reproductive Techniques, Assisted61.4% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Bazedoxifene AcetateExisting use: Postmenopausal osteoporosis61.4% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Atorvastatin CalciumExisting use: Abnormal circulating lipid concentration, Acute myocardial infarction, Angina pectoris and 10 more61.2% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.