Promazine Hydrochloride
FDA-approved product (tablet, oral), marketed as Promazine Hydrochloride, Sparine.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psychosis
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Phenothiazines with aliphatic side-chain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Promazine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- LoxapineExisting use: Agitation, Bipolar disorder, Bipolar I disorder and 2 more58.8% AI-predicted activityagainst M. tuberculosis37 registered studies
- Meclizine HydrochlorideExisting use: Allergic disease, Motion sickness, Nausea and 3 more58.8% AI-predicted activityagainst M. tuberculosis11 registered studies
- PralsetinibExisting use: Cancer, Medullary thyroid gland carcinoma, Neoplasm and 1 more58.8% AI-predicted activityagainst M. tuberculosis19 registered studies
- ElvitegravirExisting use: HIV infection, HIV-1 infection, Viral disease58.7% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Emedastine DifumarateExisting use: Allergic conjunctivitis, Eye allergy58.6% AI-predicted activityagainst M. tuberculosis2 registered studies
- Flavoxate HydrochlorideExisting use: Dysuria, Prostatitis, Urethritis and 1 more58.6% AI-predicted activityagainst M. tuberculosis2 registered studies
- MirtazapineExisting use: Depressive disorder, Insomnia, Major depressive disorder58.6% AI-predicted activityagainst M. tuberculosis50+ registered studies
- PraziquantelExisting use: Helminthiasis, Infection, Opisthorchiasis and 1 more58.6% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Latanoprostene BunodExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma58.6% AI-predicted activityagainst M. tuberculosis9 registered studies
- IbrutinibExisting use: Cancer, Chronic lymphocytic leukemia, Macroglobulinemia and 3 more58.5% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Doxazosin MesylateExisting use: Benign prostatic hyperplasia, Hypertension, Myocardial infarction58.4% AI-predicted activityagainst M. tuberculosis50+ registered studies
- LoratadineExisting use: Allergic disease, Allergic rhinitis, Pruritus and 3 more58.4% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.