Promazine Hydrochloride
FDA-approved product (tablet, oral), marketed as Promazine Hydrochloride, Sparine.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psychosis
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Phenothiazines with aliphatic side-chain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Promazine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Paroxetine MesylateExisting use: Anxiety disorder, Depressive disorder, Major depressive disorder and 5 more58.4% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Elagolix SodiumExisting use: Endometriosis58.3% AI-predicted activityagainst M. tuberculosis24 registered studies
- FluconazoleExisting use: Candidiasis, Cryptococcal meningitis, Urinary tract infection and 1 more58.2% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Ribociclib SuccinateExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 1 more58.2% AI-predicted activityagainst M. tuberculosis1 registered study
- AlpelisibExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 2 more58.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Candesartan CilexetilExisting use: Angina pectoris, Congestive heart failure, Diabetes mellitus and 4 more58.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- MinoxidilExisting use: Alopecia, Androgenetic alopecia, Hypertension and 1 more58.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Sonidegib PhosphateExisting use: Basal cell carcinoma, Neoplasm58.0% AI-predicted activityagainst M. tuberculosis2 registered studies
- Paliperidone PalmitateExisting use: Mental or behavioural disorder, Psychosis, Schizoaffective disorder and 1 more58.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- OxytocinExisting use: Hemorrhage, Uterine Inertia57.9% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Prazosin HydrochlorideExisting use: Diabetes mellitus, Hypertension57.9% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Gonadorelin AcetateExisting use: Gonadotropin-releasing hormones, Tests for fertility disturbances57.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.