Promazine Hydrochloride
FDA-approved product (tablet, oral), marketed as Promazine Hydrochloride, Sparine.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psychosis
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Phenothiazines with aliphatic side-chain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Promazine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Berotralstat DihydrochlorideExisting use: Hereditary angioedema57.8% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- Citalopram HydrobromideExisting use: Depressive disorder, Major depressive disorder57.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Escitalopram OxalateExisting use: Anxiety disorder, Depressive disorder, Generalized anxiety disorder and 1 more57.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- EtretinateExisting use: Psoriasis57.8% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- Mesoridazine BesylateExisting use: Psychosis57.8% AI-predicted activityagainst M. tuberculosis2 registered studies
- Setmelanotide AcetateExisting use: Obesity57.8% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- Tafenoquine SuccinateExisting use: Malaria, Plasmodium vivax malaria57.8% AI-predicted activityagainst M. tuberculosis42 registered studies
- Glasdegib MaleateExisting use: Acute myeloid leukemia, Cancer, Neoplasm57.7% AI-predicted activityagainst M. tuberculosis2 registered studies
- NilotinibExisting use: Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Chronic myelogenous leukemia57.7% AI-predicted activityagainst M. tuberculosis50+ registered studies
- AcitretinExisting use: Psoriasis, Psoriasis vulgaris57.6% AI-predicted activityagainst M. tuberculosis42 registered studies
- Alogliptin BenzoateExisting use: Type 2 diabetes mellitus57.6% AI-predicted activityagainst M. tuberculosis10 registered studies
- GrazoprevirExisting use: Chronic hepatitis C virus infection57.6% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.