Promazine Hydrochloride
FDA-approved product (tablet, oral), marketed as Promazine Hydrochloride, Sparine.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psychosis
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Phenothiazines with aliphatic side-chain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Promazine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- RofecoxibExisting use: Rheumatic disease57.2% AI-predicted activityagainst M. tuberculosis32 registered studies
- Sildenafil CitrateExisting use: Connective tissue disease, Erectile dysfunction, Idiopathic and/or familial pulmonary arterial hypertension and 3 more57.2% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Rezafungin AcetateExisting use: Candidemia, Candidiasis, Candidiasis, Invasive57.2% AI-predicted activityagainst M. tuberculosis5 registered studies
- FamotidineExisting use: Chest pain, Duodenal ulcer, Dyspepsia and 7 more57.2% AI-predicted activityagainst M. tuberculosis50+ registered studies
- IdelalisibExisting use: Cancer, Chronic lymphocytic leukemia, Neoplasm and 2 more57.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Halofantrine HydrochlorideExisting use: Malaria57.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
- TafluprostExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma57.1% AI-predicted activityagainst M. tuberculosis37 registered studies
- Spirapril HydrochlorideExisting use: Cardiovascular disease57.1% AI-predicted activityagainst M. tuberculosis3 registered studies
- Trametinib Dimethyl SulfoxideExisting use: Cancer, Cutaneous melanoma, Glioblastoma multiforme and 5 more57.0% AI-predicted activityagainst M. tuberculosis16 registered studies
- SincalideExisting use: Tests for bile duct patency57.0% AI-predicted activityagainst M. tuberculosis10 registered studies
- AprepitantExisting use: Cancer, Chemotherapy-induced nausea and vomiting, Nausea and 3 more57.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Galantamine HydrobromideExisting use: Alzheimer disease, Dementia57.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.