Promazine Hydrochloride
FDA-approved product (tablet, oral), marketed as Promazine Hydrochloride, Sparine.
- Registered studies
- 0
- Lab records
- 0
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Psychosis
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Phenothiazines with aliphatic side-chain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli19.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Promazine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Acoramidis HydrochlorideExisting use: Amyloidosis, Cardiomyopathy, Male infertility56.9% AI-predicted activityagainst M. tuberculosis5 registered studies
- CabergolineExisting use: Hypothalamic neoplasm, Parkinson disease56.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Capmatinib HydrochlorideExisting use: Cancer, Neoplasm, Non-small cell lung carcinoma56.8% AI-predicted activityagainst M. tuberculosis3 registered studies
- Daclatasvir DihydrochlorideExisting use: Chronic hepatitis C virus infection, Viral disease56.8% AI-predicted activityagainst M. tuberculosis2 registered studies
- Dasabuvir SodiumExisting use: Chronic hepatitis C virus infection, Hepatitis C virus infection, Viral disease56.8% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- Fosaprepitant DimeglumineExisting use: Cancer, Chemotherapy-induced nausea and vomiting, Nausea and 3 more56.8% AI-predicted activityagainst M. tuberculosis21 registered studies
- LifitegrastExisting use: Dry eye syndrome, Eye disease56.8% AI-predicted activityagainst M. tuberculosis39 registered studies
- OlaparibExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 9 more56.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- VoxelotorExisting use: Anemia, Anemia (phenotype), Sickle cell anemia56.8% AI-predicted activityagainst M. tuberculosis31 registered studies
- Zavegepant HydrochlorideExisting use: Migraine disorder56.8% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- IvosidenibExisting use: Acute myeloid leukemia, Cholangiocarcinoma56.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- LorlatinibExisting use: Cancer, Lymphoma, Neoplasm and 1 more56.7% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.