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AMR Drug RepurposingSmart Screeningresearch prototype

Levocetirizine Dihydrochloride

FDA-approved product (tablet, oral), marketed as Levocetirizine Dihydrochloride, Levocetirizine Hydrochloride, Xyzal and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Levocetirizine Dihydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Allergic disease
  • Rhinitis, Allergic, Perennial
  • Seasonal allergic rhinitis
  • Skin disease
  • Urticaria

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Piperazine derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae26.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Levocetirizine Dihydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Levocetirizine Dihydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Montelukast and Fexofenadine Versus Montelukast and Levocetrizine Combination in Allergic Rhinitis

    NCT02551536 · start 2014-04

    Registered record
    Registry ID
    NCT02551536
    Conditions
    Allergic Rhinitis
    Interventions
    Montelukast; Fexofenadine; Levocetrizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-04
    Completion
    2015-06
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionMontelukast; Fexofenadine; Levocetrizine
    PhasePhase 4
    Registry statusCompleted

  • Efficacy and Safety of Concomitant Montelukast Sodium and Levocetirizine Dihydrochloride in Perennial Allergic Rhinitis (PAR) Patients

    NCT01640535 · start 2012-06

    Registered record
    Registry ID
    NCT01640535
    Conditions
    Perennial Allergic Rhinitis
    Interventions
    Montelukast + Levocetirizine; Levocetirizine; Montelukast
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-06
    Completion
    2013-02
    Enrolment
    283

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPerennial Allergic Rhinitis
    InterventionMontelukast + Levocetirizine; Levocetirizine; Montelukast
    PhasePhase 3
    Registry statusCompleted

  • Pharmacokinetic Study of Levocetirizine Oral Solution

    NCT01622283 · start 2012-05-02

    Registered record
    Registry ID
    NCT01622283
    Conditions
    Rhinitis, Allergic, Perennial and Seasonal
    Interventions
    Levocetirizine; Cetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-05-02
    Completion
    2012-06-10
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Perennial and Seasonal
    InterventionLevocetirizine; Cetirizine
    PhasePhase 1
    Registry statusCompleted

  • Effects of Levocetirizine and Hydroxyzine on Cognitive and Psychomotor Functioning During Simulated Diving

    NCT01496911 · start 2012-04

    Registered record
    Registry ID
    NCT01496911
    Conditions
    Healthy Volunteers
    Interventions
    Levocetirizine; Hydroxyzine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-04
    Completion
    2012-10
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionLevocetirizine; Hydroxyzine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Safety Study of Levocetirizine Oral Solution for Japanese Pediatrics

    NCT01563081 · start 2012-04

    Registered record
    Registry ID
    NCT01563081
    Conditions
    Rhinitis
    Interventions
    Levocetirizine; Levocetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-04
    Completion
    2012-08
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis
    InterventionLevocetirizine; Levocetirizine
    PhasePhase 3
    Registry statusCompleted

  • Bioequivalence Study of Levocetirizine Dihydrochloride Tablets 5 mg Under Fasting Condition

    NCT01557439 · start 2012-02

    Registered record
    Registry ID
    NCT01557439
    Conditions
    Fasting State
    Interventions
    Levocetirizine Dihydrochloride 5 mg Tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-02
    Completion
    2012-03
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFasting State
    InterventionLevocetirizine Dihydrochloride 5 mg Tablets
    PhasePhase 1
    Registry statusCompleted

  • Bioequivalence Study of Levocetirizine Dihydrochloride Tablets 5 mg Under Fed Condition

    NCT01567501 · start 2012-02

    Registered record
    Registry ID
    NCT01567501
    Conditions
    Fed
    Interventions
    Levocetirizine Dihydrochloride tablets 5 mg; Levocetirizine Dihydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-02
    Completion
    2012-03
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFed
    InterventionLevocetirizine Dihydrochloride tablets 5 mg; Levocetirizine Dihydrochloride
    PhasePhase 1
    Registry statusCompleted

  • A Drug Interaction Study of Montelukast and Levocetirizine

    NCT01491503 · start 2011-11

    Registered record
    Registry ID
    NCT01491503
    Conditions
    Healthy
    Interventions
    Levocetirizine; montelukast sodium; Montelukast & levocetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-11
    Completion
    2012-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionLevocetirizine; montelukast sodium; Montelukast & levocetirizine
    PhasePhase 1
    Registry statusCompleted

  • Characterization of the Role of Histamine in Children With Asthma

    NCT01392859 · start 2011-06

    Registered record
    Registry ID
    NCT01392859
    Conditions
    Asthma; Allergic Asthma; Non-allergic Asthma
    Interventions
    Levocetirizine 0.5 Mg/mL Oral Solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2011-06
    Completion
    2015-03-29
    Enrolment
    211

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma; Allergic Asthma; Non-allergic Asthma
    InterventionLevocetirizine 0.5 Mg/mL Oral Solution
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Drug Use Investigation for XYZAL®

    NCT01445262 · start 2011-02

    Registered record
    Registry ID
    NCT01445262
    Conditions
    Rhinitis, Allergic, Perennial and Seasonal
    Interventions
    Levocetirizine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-02
    Completion
    2013-12
    Enrolment
    10,728

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Perennial and Seasonal
    InterventionLevocetirizine
    PhaseNot recorded
    Registry statusCompleted

  • Safety Study of Levocetirizine and Fexofenadine

    NCT01586091 · start 2011-02

    Registered record
    Registry ID
    NCT01586091
    Conditions
    Pruritus; Chronic Urticaria; Allergic Rhinitis
    Interventions
    Levocetirizine Oral Tablet; Fexofenadine 60 Mg Oral Tablet; Placebo Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-02
    Completion
    2012-02
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPruritus; Chronic Urticaria; Allergic Rhinitis
    InterventionLevocetirizine Oral Tablet; Fexofenadine 60 Mg Oral Tablet; Placebo Oral Tablet
    PhasePhase 4
    Registry statusCompleted

  • Omnaris Versus Levocetirizine Phase 4 Study

    NCT01430260 · start 2011-01

    Registered record
    Registry ID
    NCT01430260
    Conditions
    Allergic Rhinitis
    Interventions
    Ciclesonide; Levocetirizine; Ciclesonide & Levocetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-01
    Completion
    2012-07
    Enrolment
    349

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionCiclesonide; Levocetirizine; Ciclesonide & Levocetirizine
    PhasePhase 4
    Registry statusCompleted

  • 3-D Visualization of the Anti-Obstructive Effect of Levocetirizine

    NCT01000792 · start 2009-11

    Registered record
    Registry ID
    NCT01000792
    Conditions
    Allergic Rhinitis
    Interventions
    Levocetirizine; Levocetirizine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-11
    Completion
    2010-07
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionLevocetirizine; Levocetirizine
    PhasePhase 3
    Registry statusCompleted

  • The Effect of Levocetirizine on Inflammatory Mediators in Dermatographism

    NCT01008592 · start 2009-04

    Registered record
    Registry ID
    NCT01008592
    Conditions
    Rhinitis; Urticaria
    Interventions
    levocetirizine or placebo
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2009-04
    Completion
    2010-09
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis; Urticaria
    Interventionlevocetirizine or placebo
    PhaseNot recorded
    Registry statusTerminated

  • Anti-inflammatory H1 Antihistamines Allergic Rhinitis

    NCT02507635 · start 2009-02

    Registered record
    Registry ID
    NCT02507635
    Conditions
    Allergic Rhinitis
    Interventions
    Levocetirizine; Desloratadine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-02
    Completion
    2013-05
    Enrolment
    115

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionLevocetirizine; Desloratadine
    PhasePhase 4
    Registry statusCompleted