Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Cetirizine Hydrochloride

FDA-approved product (tablet, oral), marketed as Cetirizine Hydrochloride, Cetirizine Hydrochloride Allergy, Cetirizine Hydrochloride Hives and 11 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cetirizine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Allergic conjunctivitis
  • Allergic disease
  • Allergic rhinitis
  • Eye allergy
  • Nasal congestion
  • Pruritus
  • Rhinitis, Allergic, Perennial
  • Seasonal allergic rhinitis
  • Urticaria

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Piperazine derivatives; Other antiallergics
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae26.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cetirizine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cetirizine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Study of Bronchodilation Effects of Cetirizine

    NCT01781507 · start 2011-06

    Registered record
    Registry ID
    NCT01781507
    Conditions
    Allergic Rhinitis; Asthma
    Interventions
    Cetirizine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-06
    Completion
    2011-12
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis; Asthma
    InterventionCetirizine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of AC-170 for the Treatment of Allergic Conjunctivitis in the Conjunctival Allergen Challenge (CAC) Model

    NCT01332188 · start 2011-04

    Registered record
    Registry ID
    NCT01332188
    Conditions
    Allergic Conjunctivitis
    Interventions
    AC-170 0.05%; AC-170 0.1%; AC-170 0.24%; AC-170 0%
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2011-04
    Completion
    2011-10
    Enrolment
    101

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Conjunctivitis
    InterventionAC-170 0.05%; AC-170 0.1%; AC-170 0.24%; AC-170 0%
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Rhinitis, Cognition and Driving Performance

    NCT01318681 · start 2011-01

    Registered record
    Registry ID
    NCT01318681
    Conditions
    Seasonal Allergic Rhinitis; Driving Ability; Cognition
    Interventions
    cetirizine 10 mg; fluticasone furoate; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-01
    Completion
    2012-10
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis; Driving Ability; Cognition
    Interventioncetirizine 10 mg; fluticasone furoate; placebo
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of AC-150 for the Treatment of Allergic Conjunctivitis in the Enviro-CAC™ Model

    NCT01134328 · start 2010-05

    Registered record
    Registry ID
    NCT01134328
    Conditions
    Allergic Conjunctivitis
    Interventions
    AC-150 Combo; AC-150A 0.1%; AC-150B 0.005%; Vehicle
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-05
    Completion
    2010-07
    Enrolment
    83

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Conjunctivitis
    InterventionAC-150 Combo; AC-150A 0.1%; AC-150B 0.005%; Vehicle
    PhasePhase 2
    Registry statusCompleted

  • Is Levocetirizine Less Sedating Than Cetirizine?

    NCT00826943 · start 2009-01

    Registered record
    Registry ID
    NCT00826943
    Conditions
    Allergic Rhinitis
    Interventions
    Cetirizine; Levocetirizine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2009-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionCetirizine; Levocetirizine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Allergen Challenge Chamber Study With Single Dose Oral GSK835726 Compared With Placebo

    NCT00851344 · start 2008-09

    Registered record
    Registry ID
    NCT00851344
    Conditions
    Rhinitis, Allergic, Seasonal
    Interventions
    GSK835726 (10mg); GSK835726 (50mg); GSK835726 (100mg); Cetirizine (10mg); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-09
    Completion
    2008-11
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Seasonal
    InterventionGSK835726 (10mg); GSK835726 (50mg); GSK835726 (100mg); Cetirizine (10mg) +1 more
    PhasePhase 2
    Registry statusCompleted

  • Phase 1 Study of Levocetirizine

    NCT02447393 · start 2008-03-18

    Registered record
    Registry ID
    NCT02447393
    Conditions
    Dermatitis
    Interventions
    levocetirizine; cetirizine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-03-18
    Completion
    2008-04-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis
    Interventionlevocetirizine; cetirizine; placebo
    PhasePhase 1
    Registry statusCompleted

  • Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis

    NCT00488176 · start 2007-04

    Registered record
    Registry ID
    NCT00488176
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    montelukast; cetirizine; montelukast and cetirizine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2007-04
    Completion
    2013-12
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    Interventionmontelukast; cetirizine; montelukast and cetirizine; placebo
    PhasePhase 4
    Registry statusUnknown

  • A Relative Bioavailability Study of Cetirizine HCl 10 mg Tablets Under Fasting Conditions

    NCT00864279 · start 2006-08

    Registered record
    Registry ID
    NCT00864279
    Conditions
    Healthy
    Interventions
    Cetirizine Hydrochloride 10 mg tablets, single dose; Zyrtec® 10 mg tablets, single dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-08
    Completion
    2006-09
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCetirizine Hydrochloride 10 mg tablets, single dose; Zyrtec® 10 mg tablets, single dose
    PhasePhase 1
    Registry statusCompleted

  • Study to Assess the Effect of a Combination of Cetirizine With Pseudoephedrine Versus Cetirizine Alone on Symptoms in Patients With Allergic Rhinitis

    NCT00334698 · start 2006-07

    Registered record
    Registry ID
    NCT00334698
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    Cetirizine; Pseudoephedrine; Cetirizine with Pseudoephedrine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-07
    Completion
    2006-09
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    InterventionCetirizine; Pseudoephedrine; Cetirizine with Pseudoephedrine
    PhaseNot applicable
    Registry statusCompleted

  • Cetirizine Hydrochloride Tablets, 10 mg Bioequivalence Study of Dr.Reddy's Under Fasting Condition

    NCT01064102 · start 2006-01

    Registered record
    Registry ID
    NCT01064102
    Conditions
    Healthy
    Interventions
    Cetirizine Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-01
    Completion
    2006-02
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCetirizine Hydrochloride
    PhasePhase 1
    Registry statusCompleted

  • Randomized Phase III Study to Evaluate the Efficacy and Safety of Xyzal® (Levocetirizine) vs Zyrtec® (Cetirizine) in Subjects With Dermatitis and Eczema

    NCT00375713 · start 2005-10

    Registered record
    Registry ID
    NCT00375713
    Conditions
    Dermatitis; Eczema
    Interventions
    Levocetirizine; Cetirizine; Placebo-Levocetirizine; Placebo-Cetirizine; Standard topical steroid (1% hydrocortisone) ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-10
    Completion
    2006-05
    Enrolment
    466

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis; Eczema
    InterventionLevocetirizine; Cetirizine; Placebo-Levocetirizine; Placebo-Cetirizine +1 more
    PhasePhase 3
    Registry statusCompleted

  • Study Of Atopic Dermatitis In Pediatrics

    NCT00257569 · start 2005-08

    Registered record
    Registry ID
    NCT00257569
    Conditions
    Dermatitis, Atopic
    Interventions
    Cetirizine Dry Syrup
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-08
    Completion
    Not recorded
    Enrolment
    278

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis, Atopic
    InterventionCetirizine Dry Syrup
    PhasePhase 3
    Registry statusCompleted

  • Efficacy Study for the Symptomatic Treatment of Seasonal Allergic Rhinitis

    NCT00504933 · start 2005-05

    Registered record
    Registry ID
    NCT00504933
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    bilastine; Cetirizine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-05
    Completion
    2005-11
    Enrolment
    683

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    Interventionbilastine; Cetirizine; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Bioequivalence Study of Cetirizine Hydrochloride 10mg Tablets Under Fasting Conditions

    NCT00776139 · start 2004-10

    Registered record
    Registry ID
    NCT00776139
    Conditions
    Healthy
    Interventions
    Cetirizine Hydrochloride 10 mg tablet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-10
    Completion
    2004-12
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCetirizine Hydrochloride 10 mg tablet
    PhaseNot applicable
    Registry statusCompleted