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AMR Drug RepurposingSmart Screeningresearch prototype

Hydroxyzine Pamoate

FDA-approved product (capsule, oral), marketed as Atarax, Hydroxyzine, Hydroxyzine Hydrochloride and 4 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Hydroxyzine Pamoate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anxiety
  • Anxiety disorder
  • Neurotic disorder
  • Pruritus
  • Skin disease
  • Urticaria

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Diphenylmethane derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA40.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Hydroxyzine Pamoate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Hydroxyzine Pamoate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Relative Bioavailability Study to Evaluate Cetirizine HCl Gummy 10 mg and Cetirizine HCl Oral Tablets 10 mg

    NCT04071821 · start 2025-05-01

    Registered record
    Registry ID
    NCT04071821
    Conditions
    Allergy
    Interventions
    cetirizine HCl Gummy; Zyrtec tablet 10mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2025-05-01
    Completion
    2025-09-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergy
    Interventioncetirizine HCl Gummy; Zyrtec tablet 10mg
    PhasePhase 1
    Registry statusUnknown

  • The Impact of Airway Allergic Diseases on Children's and Parents' Quality of Life

    NCT06535087 · start 2024-07-20

    Registered record
    Registry ID
    NCT06535087
    Conditions
    Pediatric Asthma; Rhinitis, Allergic; Quality of Life
    Interventions
    Subcutaneous immunotherapy / Standard Treatment for Asthma and Rhinitis
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2024-07-20
    Completion
    2027-05-31
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric Asthma; Rhinitis, Allergic; Quality of Life
    InterventionSubcutaneous immunotherapy / Standard Treatment for Asthma and Rhinitis
    PhaseNot recorded
    Registry statusRecruiting

  • Efficacy of Hydroxyzine for Patients With Panic Disorder

    NCT05737511 · start 2023-12-30

    Registered record
    Registry ID
    NCT05737511
    Conditions
    Panic Disorder
    Interventions
    Hydroxyzine; Escitalopram Oxalate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2023-12-30
    Completion
    2026-12-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPanic Disorder
    InterventionHydroxyzine; Escitalopram Oxalate
    PhasePhase 4
    Registry statusNot yet recruiting

  • RELIEF OF PSYCHOEMOTIONAL STRESS USING XENON SEDATION

    NCT06080100 · start 2023-11-01

    Registered record
    Registry ID
    NCT06080100
    Conditions
    Psychological Stress; Anesthesia; Anxiety; Xenon
    Interventions
    Xenon; premedication hydroxyzine 25 mg
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2023-11-01
    Completion
    2026-09-01
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsychological Stress; Anesthesia; Anxiety; Xenon
    InterventionXenon; premedication hydroxyzine 25 mg
    PhaseEarly phase 1
    Registry statusCompleted

  • Comparison Between Oral Melatonin and Hydroxyzine in Pediatric Patients Undergoing Adenotonsillectomy

    NCT05680584 · start 2023-02-01

    Registered record
    Registry ID
    NCT05680584
    Conditions
    Effect of Drug; Anxiety
    Interventions
    Melatonin 3 MG; Hydroxyzine Pill; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2023-02-01
    Completion
    2024-01-30
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEffect of Drug; Anxiety
    InterventionMelatonin 3 MG; Hydroxyzine Pill; Placebo
    PhasePhase 1
    Registry statusUnknown

  • The Effect of Switching the H1-antagonist Clemastine to Cetirizine in Premedication Regimens During Paclitaxel Treatment

    NCT06039137 · start 2022-06-01

    Registered record
    Registry ID
    NCT06039137
    Conditions
    Solid Tumor
    Interventions
    Cetirizine; Clemastine IV
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-06-01
    Completion
    2023-10-31
    Enrolment
    395

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSolid Tumor
    InterventionCetirizine; Clemastine IV
    PhaseNot recorded
    Registry statusCompleted

  • CLOZAPINE Response in Biotype-1

    NCT04580134 · start 2022-03-01

    Registered record
    Registry ID
    NCT04580134
    Conditions
    Schizophrenia; Schizoaffective Disorder; Bipolar 1 Disorder
    Interventions
    clozapine; risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2022-03-01
    Completion
    2027-04-30
    Enrolment
    524

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder; Bipolar 1 Disorder
    Interventionclozapine; risperidone
    PhasePhase 4
    Registry statusRecruiting

  • Melatonin Versus Hydroxizin for Pre Operative Anxiety in Elderly Patients With Hip Fracture

    NCT05224167 · start 2022-03-01

    Registered record
    Registry ID
    NCT05224167
    Conditions
    Preoperative Anxiety
    Interventions
    Melatonin 5 MG Sublingual Tablet; Hydroxyzine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-03-01
    Completion
    2022-07-30
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreoperative Anxiety
    InterventionMelatonin 5 MG Sublingual Tablet; Hydroxyzine
    PhaseNot applicable
    Registry statusUnknown

  • The Effect of Cetirizine HCl on Exercise-induced Arterial Hypoxemia in Highly-trained Swimmers

    NCT05095311 · start 2021-05-19

    Registered record
    Registry ID
    NCT05095311
    Conditions
    Exercise-induced Arterial Hypoxemia
    Interventions
    Cetirizine HCl; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2021-05-19
    Completion
    2022-04-27
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionExercise-induced Arterial Hypoxemia
    InterventionCetirizine HCl; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Efficacy of Antihistamine Drugs as Medical Expulsive Therapy Alone or in Combination With Alpha Blockers: A Prospective Randomized Controlled Study

    NCT06754410 · start 2021-03-01

    Registered record
    Registry ID
    NCT06754410
    Conditions
    Lower Ureteric Stones
    Interventions
    Tamsulosin; Cetirizine; Cetirizine + Tamsulosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2021-03-01
    Completion
    2024-03-01
    Enrolment
    480

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLower Ureteric Stones
    InterventionTamsulosin; Cetirizine; Cetirizine + Tamsulosin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Virtual Reality Technology on Pain Perception and Anxiety Levels in Adolescents and Young Adults During Third Molar Germ Avulsion Surgery (VIDAMO)

    NCT04609956 · start 2021-02-16

    Registered record
    Registry ID
    NCT04609956
    Conditions
    Anxiety, Dental
    Interventions
    Virtual reality; Standard
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-02-16
    Completion
    2024-05-28
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety, Dental
    InterventionVirtual reality; Standard
    PhaseNot applicable
    Registry statusCompleted

  • Topical Cetirizine 1% vs Minoxidil 5% Gel in Treatment of Androgenetic Alopecia

    NCT04293822 · start 2020-06

    Registered record
    Registry ID
    NCT04293822
    Conditions
    Androgenetic Alopecia
    Interventions
    Cetirizine; Minoxidil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2020-06
    Completion
    2021-11
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAndrogenetic Alopecia
    InterventionCetirizine; Minoxidil
    PhasePhase 4
    Registry statusUnknown

  • Cetirizine Chewable Bioequivalence and Food Effect Study

    NCT03772158 · start 2018-12-11

    Registered record
    Registry ID
    NCT03772158
    Conditions
    Allergy
    Interventions
    Cetirizine 10mg; Cetirizine 10 mg; Cetirizine 10 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2018-12-11
    Completion
    2019-02-03
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergy
    InterventionCetirizine 10mg; Cetirizine 10 mg; Cetirizine 10 mg
    PhasePhase 1
    Registry statusCompleted

  • Presurgery Anxiolysis in Children Treated With Hydroxyzine Versus Non-pharmacological Intervention (Distractoria Technique Clown)

    NCT03324828 · start 2017-11-01

    Registered record
    Registry ID
    NCT03324828
    Conditions
    Anxiety
    Interventions
    Hydroxyzine; Clowns intervention
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-11-01
    Completion
    2020-05-29
    Enrolment
    170

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety
    InterventionHydroxyzine; Clowns intervention
    PhasePhase 4
    Registry statusTerminated

  • Mast Cells in Male Pelvic Pain and and Lower Urinary Tract Dysfunction

    NCT03167216 · start 2017-08-01

    Registered record
    Registry ID
    NCT03167216
    Conditions
    Chronic Prostatitis With Chronic Pelvic Pain Syndrome
    Interventions
    Cromolyn Sodium; Cetirizine Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2017-08-01
    Completion
    2022-06-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Prostatitis With Chronic Pelvic Pain Syndrome
    InterventionCromolyn Sodium; Cetirizine Hydrochloride
    PhaseEarly phase 1
    Registry statusCompleted