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AMR Drug RepurposingSmart Screeningresearch prototype

Hydroxyzine Pamoate

FDA-approved product (capsule, oral), marketed as Atarax, Hydroxyzine, Hydroxyzine Hydrochloride and 4 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Hydroxyzine Pamoate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anxiety
  • Anxiety disorder
  • Neurotic disorder
  • Pruritus
  • Skin disease
  • Urticaria

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Diphenylmethane derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA40.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Hydroxyzine Pamoate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Hydroxyzine Pamoate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Is Levocetirizine Less Sedating Than Cetirizine?

    NCT00826943 · start 2009-01

    Registered record
    Registry ID
    NCT00826943
    Conditions
    Allergic Rhinitis
    Interventions
    Cetirizine; Levocetirizine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2009-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionCetirizine; Levocetirizine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Allergen Challenge Chamber Study With Single Dose Oral GSK835726 Compared With Placebo

    NCT00851344 · start 2008-09

    Registered record
    Registry ID
    NCT00851344
    Conditions
    Rhinitis, Allergic, Seasonal
    Interventions
    GSK835726 (10mg); GSK835726 (50mg); GSK835726 (100mg); Cetirizine (10mg); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-09
    Completion
    2008-11
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinitis, Allergic, Seasonal
    InterventionGSK835726 (10mg); GSK835726 (50mg); GSK835726 (100mg); Cetirizine (10mg) +1 more
    PhasePhase 2
    Registry statusCompleted

  • Palonosetron and Hydroxyzine to Reduce Opioid Withdrawal

    NCT00661674 · start 2008-04

    Registered record
    Registry ID
    NCT00661674
    Conditions
    Substance-Related Disorders
    Interventions
    Palonosetron; Hydroxyzine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-04
    Completion
    2008-08
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubstance-Related Disorders
    InterventionPalonosetron; Hydroxyzine; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Phase 1 Study of Levocetirizine

    NCT02447393 · start 2008-03-18

    Registered record
    Registry ID
    NCT02447393
    Conditions
    Dermatitis
    Interventions
    levocetirizine; cetirizine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-03-18
    Completion
    2008-04-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis
    Interventionlevocetirizine; cetirizine; placebo
    PhasePhase 1
    Registry statusCompleted

  • Taste and Local Tolerance Study of NLA Nasal Spray in Patients With Allergic Rhinitis

    NCT00533637 · start 2007-09

    Registered record
    Registry ID
    NCT00533637
    Conditions
    Allergic Rhinitis
    Interventions
    Cetirizine dihydrochloride (10 mg/ml) liposomal formulation; Cetirizine dihydrochloride (10 mg/ml) buffer solution; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-09
    Completion
    2007-12
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAllergic Rhinitis
    InterventionCetirizine dihydrochloride (10 mg/ml) liposomal formulation; Cetirizine dihydrochloride (10 mg/ml) buffer solution; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation in Children With Allergic Rhinitis

    NCT00488176 · start 2007-04

    Registered record
    Registry ID
    NCT00488176
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    montelukast; cetirizine; montelukast and cetirizine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2007-04
    Completion
    2013-12
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    Interventionmontelukast; cetirizine; montelukast and cetirizine; placebo
    PhasePhase 4
    Registry statusUnknown

  • A Relative Bioavailability Study of Cetirizine HCl 10 mg Tablets Under Fasting Conditions

    NCT00864279 · start 2006-08

    Registered record
    Registry ID
    NCT00864279
    Conditions
    Healthy
    Interventions
    Cetirizine Hydrochloride 10 mg tablets, single dose; Zyrtec® 10 mg tablets, single dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-08
    Completion
    2006-09
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCetirizine Hydrochloride 10 mg tablets, single dose; Zyrtec® 10 mg tablets, single dose
    PhasePhase 1
    Registry statusCompleted

  • Study to Assess the Effect of a Combination of Cetirizine With Pseudoephedrine Versus Cetirizine Alone on Symptoms in Patients With Allergic Rhinitis

    NCT00334698 · start 2006-07

    Registered record
    Registry ID
    NCT00334698
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    Cetirizine; Pseudoephedrine; Cetirizine with Pseudoephedrine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-07
    Completion
    2006-09
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    InterventionCetirizine; Pseudoephedrine; Cetirizine with Pseudoephedrine
    PhaseNot applicable
    Registry statusCompleted

  • Skin Toxicity Treatment in Metastatic Colorectal Cancer (mCRC) Patients Receiving Panitumumab + Irinotecan-based Therapy

    NCT00332163 · start 2006-04

    Registered record
    Registry ID
    NCT00332163
    Conditions
    Metastatic Colorectal Cancer; Skin Rash; Skin Toxicities; Colon Cancer; Colorectal Cancer
    Interventions
    Panitumumab; Irinotecan; FOLFIRI; Pre-emptive Skin Treatment; Reactive Skin Treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-04
    Completion
    2008-09
    Enrolment
    95

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetastatic Colorectal Cancer; Skin Rash; Skin Toxicities; Colon Cancer +1 more
    InterventionPanitumumab; Irinotecan; FOLFIRI; Pre-emptive Skin Treatment +1 more
    PhasePhase 2
    Registry statusCompleted

  • Prometa Pharmacotherapy for Methamphetamine Dependence

    NCT00260481 · start 2006-01

    Registered record
    Registry ID
    NCT00260481
    Conditions
    Drug Abuse; Drug Dependence
    Interventions
    Prometa; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2006-01
    Completion
    2008-06
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Abuse; Drug Dependence
    InterventionPrometa; Placebo
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Cetirizine Hydrochloride Tablets, 10 mg Bioequivalence Study of Dr.Reddy's Under Fasting Condition

    NCT01064102 · start 2006-01

    Registered record
    Registry ID
    NCT01064102
    Conditions
    Healthy
    Interventions
    Cetirizine Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-01
    Completion
    2006-02
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCetirizine Hydrochloride
    PhasePhase 1
    Registry statusCompleted

  • Randomized Phase III Study to Evaluate the Efficacy and Safety of Xyzal® (Levocetirizine) vs Zyrtec® (Cetirizine) in Subjects With Dermatitis and Eczema

    NCT00375713 · start 2005-10

    Registered record
    Registry ID
    NCT00375713
    Conditions
    Dermatitis; Eczema
    Interventions
    Levocetirizine; Cetirizine; Placebo-Levocetirizine; Placebo-Cetirizine; Standard topical steroid (1% hydrocortisone) ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-10
    Completion
    2006-05
    Enrolment
    466

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis; Eczema
    InterventionLevocetirizine; Cetirizine; Placebo-Levocetirizine; Placebo-Cetirizine +1 more
    PhasePhase 3
    Registry statusCompleted

  • Comparative Effects of Rupatadine 10 mg, Hydroxyzine 50 mg and Placebo on Actual Driving Performance

    NCT00162786 · start 2005-05

    Registered record
    Registry ID
    NCT00162786
    Conditions
    Healthy
    Interventions
    Rupatadine; Hydroxyzine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2005-05
    Completion
    2005-11
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionRupatadine; Hydroxyzine; Placebo
    PhasePhase 4
    Registry statusTerminated

  • Efficacy Study for the Symptomatic Treatment of Seasonal Allergic Rhinitis

    NCT00504933 · start 2005-05

    Registered record
    Registry ID
    NCT00504933
    Conditions
    Seasonal Allergic Rhinitis
    Interventions
    bilastine; Cetirizine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-05
    Completion
    2005-11
    Enrolment
    683

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeasonal Allergic Rhinitis
    Interventionbilastine; Cetirizine; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Bioequivalence Study of Cetirizine Hydrochloride 10mg Tablets Under Fasting Conditions

    NCT00776139 · start 2004-10

    Registered record
    Registry ID
    NCT00776139
    Conditions
    Healthy
    Interventions
    Cetirizine Hydrochloride 10 mg tablet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-10
    Completion
    2004-12
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionCetirizine Hydrochloride 10 mg tablet
    PhaseNot applicable
    Registry statusCompleted